TissGeneSummary for ADAM28 |
Gene summary |
Basic gene information | Gene symbol | ADAM28 |
Gene name | ADAM metallopeptidase domain 28 | |
Synonyms | ADAM 28|ADAM23|MDC-L|MDC-Lm|MDC-Ls|MDCL|eMDC II|eMDCII | |
Cytomap | UCSC genome browser: 8p21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_014265.4, NM_021777.3, | |
Description | disintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IImetalloproteinase-like, dis | |
Modification date | 20141207 | |
dbXrefs | MIM : 606188 | |
HGNC : HGNC | ||
Ensembl : ENSG00000042980 | ||
HPRD : 08391 | ||
Vega : OTTHUMG00000163780 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM28 | |
BioGPS: 10863 | ||
Pathway | NCI Pathway Interaction Database: ADAM28 | |
KEGG: ADAM28 | ||
REACTOME: ADAM28 | ||
Pathway Commons: ADAM28 | ||
Context | iHOP: ADAM28 | |
ligand binding site mutation search in PubMed: ADAM28 | ||
UCL Cancer Institute: ADAM28 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSTAD | |
Reference showing the relevant tissue of ADAM28 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM28 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 2.519157388 | 0.347517733 | 2.171639655 | 1.98E-14 | 1.91E-13 |
KIRC | 1.891712178 | 0.521242733 | 1.370469444 | 3.59E-11 | 1.33E-10 |
COAD | 0.28714081 | 1.593010041 | -1.305869231 | 9.00E-05 | 0.00033253 |
PRAD | 0.063033118 | 1.073388887 | -1.010355769 | 5.28E-05 | 0.00023904 |
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TissGene-miRNA for ADAM28 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM28 |
TissGeneSNV for ADAM28 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E340K | SKCM | 6 |
p.E536K | SKCM | 2 |
p.G603E | SKCM | 2 |
p.S90F | SKCM | 2 |
p.D135N | SKCM | 2 |
p.M61I | SKCM | 2 |
p.S570L | SKCM | 2 |
p.D736N | SKCM | 2 |
p.G577E | SKCM | 2 |
p.T266I | SKCM | 2 |
p.H349Y | SKCM | 2 |
p.G65E | SKCM | 2 |
p.I101F | READ | 1 |
p.M102K | HNSC | 1 |
p.S666F | SKCM | 1 |
p.E201K | SKCM | 1 |
p.D179N | UCEC | 1 |
p.A235S | UCEC | 1 |
p.D350N | SKCM | 1 |
p.P160L | STAD | 1 |
p.A676V | HNSC | 1 |
p.P654S | LUAD | 1 |
p.I405V | STAD | 1 |
p.D762N | SKCM | 1 |
p.P528S | SKCM | 1 |
p.S327R | ESCA | 1 |
p.I101S | DLBC | 1 |
p.P372S | SKCM | 1 |
p.D325N | SKCM | 1 |
p.G418R | HNSC | 1 |
p.G129V | LIHC | 1 |
p.E233Q | SKCM | 1 |
p.Q595K | LUAD | 1 |
p.E274D | READ | 1 |
p.G538R | SKCM | 1 |
p.V322I | COAD | 1 |
p.E642X | LIHC | 1 |
p.K586* | UCEC | 1 |
p.G109* | HNSC | 1 |
p.R35G | SKCM | 1 |
p.T593K | COAD | 1 |
p.C482R | KIRP | 1 |
p.Q200X | SKCM | 1 |
p.M560I | SKCM | 1 |
p.T297P | PAAD | 1 |
p.V669G | SKCM | 1 |
p.I206V | DLBC | 1 |
p.S747C | HNSC | 1 |
p.T299P | STAD | 1 |
p.G494V | LUAD | 1 |
p.G109* | UCEC | 1 |
p.Q49K | SARC | 1 |
p.F232L | GBM | 1 |
p.S117Y | READ | 1 |
p.V722I | PRAD | 1 |
p.M347L | STAD | 1 |
p.M730I | SKCM | 1 |
p.D736Y | BRCA | 1 |
p.P160S | SKCM | 1 |
p.Q133H | SARC | 1 |
p.D488H | CESC | 1 |
p.G150R | SKCM | 1 |
p.R687Q | LGG | 1 |
p.R578W | BLCA | 1 |
p.E51K | SKCM | 1 |
p.L79F | SKCM | 1 |
p.Y87S | UCEC | 1 |
p.H641Y | LUAD | 1 |
p.K610N | UCEC | 1 |
p.E649K | SKCM | 1 |
p.Q440K | SKCM | 1 |
p.G577R | SKCM | 1 |
p.C561F | UCEC | 1 |
p.R125S | LUAD | 1 |
p.P744A | SKCM | 1 |
p.C633* | GBM | 1 |
p.P773L | SKCM | 1 |
p.S117F | SKCM | 1 |
p.V681E | SKCM | 1 |
p.A235T | ESCA | 1 |
p.H40R | LIHC | 1 |
p.M363I | SKCM | 1 |
p.A556G | LUAD | 1 |
p.P590S | SKCM | 1 |
p.A615T | STAD | 1 |
p.E591A | LIHC | 1 |
p.A676V | COAD | 1 |
p.H415Y | SKCM | 1 |
p.L6V | LGG | 1 |
p.R230K | SKCM | 1 |
p.L330F | LGG | 1 |
p.T430A | COAD | 1 |
p.M477I | HNSC | 1 |
p.G450E | BLCA | 1 |
p.V323I | LUAD | 1 |
p.G418E | SKCM | 1 |
p.S482P | LIHC | 1 |
p.G569V | LUAD | 1 |
p.G129C | LIHC | 1 |
p.W651C | UCEC | 1 |
p.L573F | LUAD | 1 |
p.G134R | SKCM | 1 |
p.Q200* | SKCM | 1 |
p.E85Q | SKCM | 1 |
p.M171I | SKCM | 1 |
p.E596Q | HNSC | 1 |
p.G65R | SKCM | 1 |
p.G598V | ESCA | 1 |
p.V116I | SKCM | 1 |
p.E621K | SKCM | 1 |
p.G494D | SKCM | 1 |
p.G424V | LUAD | 1 |
p.P653S | SKCM | 1 |
p.S482F | SKCM | 1 |
p.N609Y | SKCM | 1 |
p.E162K | SKCM | 1 |
p.P267L | ESCA | 1 |
p.P145S | KIRC | 1 |
p.N493S | PAAD | 1 |
p.L381V | SKCM | 1 |
p.W575* | SKCM | 1 |
p.I360T | LGG | 1 |
p.D172N | SKCM | 1 |
p.D328Y | LUAD | 1 |
p.T123R | LUAD | 1 |
p.W575X | SKCM | 1 |
p.W257R | ESCA | 1 |
p.G469S | SKCM | 1 |
p.T627I | SKCM | 1 |
p.A188T | SKCM | 1 |
p.P160L | SKCM | 1 |
p.C561F | CHOL | 1 |
p.A754T | STAD | 1 |
p.E471K | SKCM | 1 |
p.Q515K | HNSC | 1 |
p.G303R | SKCM | 1 |
p.C169Y | UCEC | 1 |
p.D420E | LGG | 1 |
p.S377F | SKCM | 1 |
p.D104E | UCEC | 1 |
p.D328N | READ | 1 |
p.P481S | SKCM | 1 |
p.T62A | ESCA | 1 |
p.P475S | COAD | 1 |
p.V283F | SKCM | 1 |
p.H499Y | SKCM | 1 |
p.R287K | HNSC | 1 |
p.D698N | SKCM | 1 |
p.P528L | SKCM | 1 |
p.E274D | UCEC | 1 |
p.R714K | SKCM | 1 |
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TissGeneCNV for ADAM28 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM28 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG925828 | TMEM55A-ADAM28 | chr8:92006940 | chr8:24208468 | |
Chimerdb3.0 | ChiTaRs | NA | BU676798 | ADAM28-ADAM28 | chr8:24212605 | chr8:24212011 |
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TissGeneNet for ADAM28 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM28 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM28 |
TissGeneDrug for ADAM28 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM28 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
umls:C1458155 | Mammary Neoplasms | 3 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0020636 | Congenital hypoplasia | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0026764 | Multiple Myeloma | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | GAD |
umls:C0036572 | Seizures | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0153633 | Malignant neoplasm of brain | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0497406 | Overweight | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |