TissGeneSummary for SLC22A7 |
Gene summary |
Basic gene information | Gene symbol | SLC22A7 |
Gene name | solute carrier family 22 (organic anion transporter), member 7 | |
Synonyms | NLT|OAT2 | |
Cytomap | UCSC genome browser: 6p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_006672.3, NM_153320.2, | |
Description | hOAT2liver-specific transporternovel liver transporterorganic anion transporter 2solute carrier family 22 member 7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604995 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137204 | ||
HPRD : 05409 | ||
Vega : OTTHUMG00000014726 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A7 | |
BioGPS: 10864 | ||
Pathway | NCI Pathway Interaction Database: SLC22A7 | |
KEGG: SLC22A7 | ||
REACTOME: SLC22A7 | ||
Pathway Commons: SLC22A7 | ||
Context | iHOP: SLC22A7 | |
ligand binding site mutation search in PubMed: SLC22A7 | ||
UCL Cancer Institute: SLC22A7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of SLC22A7 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC22A7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.117205161 | 5.297328772 | -3.180123611 | 1.34E-08 | 4.00E-08 |
KICH | -1.696108117 | 4.992939883 | -6.689048 | 4.45E-11 | 3.76E-10 |
LIHC | 9.054183883 | 11.44294388 | -2.38876 | 4.85E-06 | 2.22E-05 |
KIRP | 1.304821133 | 6.743002383 | -5.43818125 | 2.56E-09 | 2.21E-08 |
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TissGene-miRNA for SLC22A7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC22A7 |
TissGeneSNV for SLC22A7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G325E | SKCM | 2 |
p.V231M | SKCM | 2 |
p.P70S | SKCM | 2 |
p.G363D | LGG | 1 |
p.A416V | CESC | 1 |
p.N358I | SARC | 1 |
p.R474Q | STAD | 1 |
p.D133N | SKCM | 1 |
p.A449S | LUAD | 1 |
p.G323R | SKCM | 1 |
p.P70L | SKCM | 1 |
p.G116D | PAAD | 1 |
p.S126Y | LUSC | 1 |
p.A84V | THCA | 1 |
p.I501M | LUAD | 1 |
p.L364P | KIRP | 1 |
p.R71Q | LUAD | 1 |
p.Y195H | KIRP | 1 |
p.L143Q | LUAD | 1 |
p.C138Y | UCEC | 1 |
p.G161E | SKCM | 1 |
p.A263V | KIRC | 1 |
p.D74Y | HNSC | 1 |
p.A56T | LUAD | 1 |
p.R255W | STAD | 1 |
p.T405M | STAD | 1 |
p.V178A | COAD | 1 |
p.G325R | SKCM | 1 |
p.L266P | UCEC | 1 |
p.G370R | ESCA | 1 |
p.G408E | SKCM | 1 |
p.S333L | SKCM | 1 |
p.G249E | SKCM | 1 |
p.R398C | PRAD | 1 |
p.T405M | PRAD | 1 |
p.L36F | LUAD | 1 |
p.R330Q | SKCM | 1 |
p.D135N | SKCM | 1 |
p.D426Y | ESCA | 1 |
p.V193I | GBM | 1 |
p.V157L | LUAD | 1 |
p.A407S | ESCA | 1 |
p.M1I | LUAD | 1 |
p.Q316K | LUAD | 1 |
p.A416G | OV | 1 |
p.R516W | LUAD | 1 |
p.E96K | SKCM | 1 |
p.R398C | LUAD | 1 |
p.V355M | SKCM | 1 |
p.G500W | LUAD | 1 |
p.R172L | SKCM | 1 |
p.V180M | THYM | 1 |
p.G251E | SKCM | 1 |
p.A416V | UCEC | 1 |
p.G325W | LUAD | 1 |
p.C301R | KIRP | 1 |
p.Q545X | KIRC | 1 |
p.Y297H | UCEC | 1 |
p.R71L | KIRP | 1 |
p.R327Q | UCEC | 1 |
p.G438E | SKCM | 1 |
p.E227Q | HNSC | 1 |
p.G163E | SKCM | 1 |
p.G408R | SKCM | 1 |
p.G206V | LUAD | 1 |
p.P268T | COAD | 1 |
p.R402H | BLCA | 1 |
p.R342W | GBM | 1 |
p.G499R | STAD | 1 |
p.V234A | LIHC | 1 |
p.A509T | PRAD | 1 |
p.Q316R | BLCA | 1 |
p.G242R | SKCM | 1 |
p.R145T | LUSC | 1 |
p.V357M | SKCM | 1 |
p.E131Q | BLCA | 1 |
p.T182A | HNSC | 1 |
p.L69F | SKCM | 1 |
p.R170L | SKCM | 1 |
p.G323E | SKCM | 1 |
p.G383E | SKCM | 1 |
p.Y498H | LUAD | 1 |
p.R398C | LGG | 1 |
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TissGeneCNV for SLC22A7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC22A7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC22A7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC22A7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC22A7 |
TissGeneDrug for SLC22A7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC22A7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0008370 | Cholestasis | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0020433 | Hyperbilirubinemia | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |