TissGeneSummary for NMU |
Gene summary |
Basic gene information | Gene symbol | NMU |
Gene name | neuromedin U | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q12 | |
Type of gene | protein-coding | |
RefGenes | NM_001292045.1, NM_001292046.1,NM_006681.3,NR_120489.1, | |
Description | neuromedin-Uprepro-NMU | |
Modification date | 20141207 | |
dbXrefs | MIM : 605103 | |
HGNC : HGNC | ||
Ensembl : ENSG00000109255 | ||
HPRD : 05485 | ||
Vega : OTTHUMG00000102161 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NMU | |
BioGPS: 10874 | ||
Pathway | NCI Pathway Interaction Database: NMU | |
KEGG: NMU | ||
REACTOME: NMU | ||
Pathway Commons: NMU | ||
Context | iHOP: NMU | |
ligand binding site mutation search in PubMed: NMU | ||
UCL Cancer Institute: NMU | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusOvary | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAOV | |
Reference showing the relevant tissue of NMU | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NMU |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.544742017 | -3.148832493 | 4.69357451 | 7.52E-20 | 8.64E-19 |
THCA | 2.606243778 | -2.507340968 | 5.113584746 | 6.62E-19 | 1.98E-17 |
LUAD | 0.712470955 | -2.987341114 | 3.699812069 | 1.29E-17 | 1.70E-16 |
BRCA | -1.521118458 | -3.510189511 | 1.989071053 | 2.93E-14 | 1.46E-13 |
HNSC | 2.360658205 | 3.688107042 | -1.327448837 | 0.0109 | 0.026686616 |
COAD | 0.530186738 | -1.013113262 | 1.5433 | 0.00872 | 0.019595405 |
STAD | 2.457673757 | 0.302411257 | 2.1552625 | 0.00307 | 0.013027226 |
KIRC | -2.489994993 | -3.520256104 | 1.030261111 | 0.000161 | 0.000332535 |
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TissGene-miRNA for NMU |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NMU |
TissGeneSNV for NMU |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A19E | ACC | 5 |
p.P151S | SKCM | 2 |
p.P40A | BLCA | 1 |
p.F83C | LIHC | 1 |
p.A19E | KIRP | 1 |
p.E49K | SKCM | 1 |
p.E97V | COAD | 1 |
p.S109L | STAD | 1 |
p.M86T | BLCA | 1 |
p.Q129* | LUSC | 1 |
p.R143T | LUAD | 1 |
p.E79G | DLBC | 1 |
p.A18E | KIRP | 1 |
p.R141I | UCEC | 1 |
p.L161* | STAD | 1 |
p.G45V | LUAD | 1 |
p.L161X | STAD | 1 |
p.Q129H | UCEC | 1 |
p.A77T | COAD | 1 |
p.F148L | DLBC | 1 |
p.E57Q | BLCA | 1 |
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TissGeneCNV for NMU |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NMU |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | GBM | TCGA-06-2559-01A | KIAA1211-NMU | 5UTR-CDS | Chr4:57045596 | Chr4:56496627 |
TCGAfusionPortal | PRADA | LUAD | TCGA-55-6969-01A | CLOCK-NMU | CDS-3UTR | Chr4:56322064 | Chr4:56461578 |
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TissGeneNet for NMU |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NMU |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NMU |
TissGeneDrug for NMU |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NMU |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0028754 | Obesity | 4 | BeFree,GAD,RGD |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree,LHGDN |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0003123 | Anorexia | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | LHGDN |
umls:C0006145 | Breast Diseases | 1 | BeFree |
umls:C0006625 | Cachexia | 1 | BeFree,LHGDN |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023470 | Myeloid Leukemia | 1 | BeFree,LHGDN |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0497406 | Overweight | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1511291 | Breast Cancer Model | 1 | BeFree |
umls:C1561826 | Overweight and obesity | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
umls:C2362324 | Pediatric Obesity | 1 | BeFree |