TissGeneSummary for CFHR4 |
Gene summary |
Basic gene information | Gene symbol | CFHR4 |
Gene name | complement factor H-related 4 | |
Synonyms | CFHL4|FHR-4|FHR4 | |
Cytomap | UCSC genome browser: 1q32 | |
Type of gene | protein-coding | |
RefGenes | NM_001201550.2, NM_001201551.1,NM_006684.4, | |
Description | complement factor H-related protein 4 | |
Modification date | 20141219 | |
dbXrefs | MIM : 605337 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134365 | ||
HPRD : 05627 | ||
Vega : OTTHUMG00000036647 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CFHR4 | |
BioGPS: 10877 | ||
Pathway | NCI Pathway Interaction Database: CFHR4 | |
KEGG: CFHR4 | ||
REACTOME: CFHR4 | ||
Pathway Commons: CFHR4 | ||
Context | iHOP: CFHR4 | |
ligand binding site mutation search in PubMed: CFHR4 | ||
UCL Cancer Institute: CFHR4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CFHR4 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CFHR4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 8.577245721 | 10.38220772 | -1.804962 | 0.000102 | 0.00035232 |
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TissGene-miRNA for CFHR4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CFHR4 |
TissGeneSNV for CFHR4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G531E | SKCM | 6 |
p.S14F | SKCM | 2 |
p.G119E | SKCM | 2 |
p.R287K | HNSC | 2 |
p.S103F | SKCM | 2 |
p.Q276* | SKCM | 2 |
p.G431E | SKCM | 2 |
p.E180K | SKCM | 2 |
p.A555V | LGG | 1 |
p.P509T | TGCT | 1 |
p.S436F | SKCM | 1 |
p.E175* | UCEC | 1 |
p.A387V | HNSC | 1 |
p.G97* | KIRC | 1 |
p.G179V | UCEC | 1 |
p.R263* | LUAD | 1 |
p.G64E | BLCA | 1 |
p.S102F | SKCM | 1 |
p.S63L | SKCM | 1 |
p.E342K | SKCM | 1 |
p.N357I | LIHC | 1 |
p.T433S | HNSC | 1 |
p.W258L | ESCA | 1 |
p.Q563H | ESCA | 1 |
p.Y313D | SKCM | 1 |
p.G129R | SKCM | 1 |
p.Y538H | DLBC | 1 |
p.G542W | LUAD | 1 |
p.L419S | STAD | 1 |
p.T87S | UCEC | 1 |
p.S128C | LUAD | 1 |
p.C72* | LUAD | 1 |
p.S127F | SKCM | 1 |
p.P398T | LUAD | 1 |
p.R85K | SKCM | 1 |
p.S350F | SKCM | 1 |
p.A555V | COAD | 1 |
p.C23F | LUAD | 1 |
p.P509Q | LUAD | 1 |
p.D442N | BLCA | 1 |
p.D195N | SARC | 1 |
p.G570D | STAD | 1 |
p.Y538C | LUAD | 1 |
p.S561L | SKCM | 1 |
p.G219R | HNSC | 1 |
p.P389T | HNSC | 1 |
p.P273S | SKCM | 1 |
p.G542V | LUAD | 1 |
p.S241F | BLCA | 1 |
p.D25G | UCEC | 1 |
p.P151T | LUAD | 1 |
p.S189F | SKCM | 1 |
p.W314* | SKCM | 1 |
p.E283Q | STAD | 1 |
p.E124K | BLCA | 1 |
p.E244* | BLCA | 1 |
p.F447I | SKCM | 1 |
p.W12R | LUAD | 1 |
p.E427* | BLCA | 1 |
p.A47E | HNSC | 1 |
p.S347F | SKCM | 1 |
p.S105Y | UCEC | 1 |
p.M398I | KIRC | 1 |
p.S436Y | COAD | 1 |
p.G542R | SKCM | 1 |
p.L560V | BLCA | 1 |
p.Q75K | LUAD | 1 |
p.N209S | BLCA | 1 |
p.S207L | SKCM | 1 |
p.G570V | THYM | 1 |
p.D169V | LUAD | 1 |
p.Y301D | HNSC | 1 |
p.F60V | UCEC | 1 |
p.T132K | HNSC | 1 |
p.G311E | SKCM | 1 |
p.Y177F | OV | 1 |
p.M397I | KIRC | 1 |
p.P510T | TGCT | 1 |
p.S89* | LUAD | 1 |
p.E260K | SKCM | 1 |
p.K457T | ESCA | 1 |
p.G119V | LUAD | 1 |
p.N526K | LGG | 1 |
p.R287C | KIRP | 1 |
p.A48E | HNSC | 1 |
p.L314V | BLCA | 1 |
p.S198F | SKCM | 1 |
p.R286C | COAD | 1 |
p.P62L | SKCM | 1 |
p.C240W | STAD | 1 |
p.F99S | UCEC | 1 |
p.D322Y | KIRC | 1 |
p.G196C | HNSC | 1 |
p.C84* | LUAD | 1 |
p.E455Q | LUAD | 1 |
p.C487W | STAD | 1 |
p.C319* | LUAD | 1 |
p.G366E | SKCM | 1 |
p.G531R | SKCM | 1 |
p.L11F | SKCM | 1 |
p.E194K | BLCA | 1 |
p.T449K | BLCA | 1 |
p.P26S | SKCM | 1 |
p.D416N | LUAD | 1 |
p.A48S | HNSC | 1 |
p.S374C | LUAD | 1 |
p.G184E | SKCM | 1 |
p.Y55C | BRCA | 1 |
p.F225V | ESCA | 1 |
p.W314X | SKCM | 1 |
p.N161K | BLCA | 1 |
p.Y291* | STAD | 1 |
p.C239* | LUAD | 1 |
p.H72Q | BRCA | 1 |
p.A141V | HNSC | 1 |
p.Y538X | STAD | 1 |
p.P143T | HNSC | 1 |
p.D188E | CESC | 1 |
p.E237Q | LUAD | 1 |
p.L172S | STAD | 1 |
p.E401Q | BLCA | 1 |
p.T320I | LUAD | 1 |
p.Q564H | ESCA | 1 |
p.K456T | ESCA | 1 |
p.G569D | STAD | 1 |
p.E421K | SKCM | 1 |
p.P329L | HNSC | 1 |
p.D149N | ESCA | 1 |
p.P26A | SKCM | 1 |
p.R157T | KIRC | 1 |
p.T253K | BRCA | 1 |
p.E154K | HNSC | 1 |
p.G553R | KIRP | 1 |
p.Q74K | LUAD | 1 |
p.S64L | UCEC | 1 |
p.G125E | SKCM | 1 |
p.S335* | LUAD | 1 |
p.E181* | BLCA | 1 |
p.F224V | ESCA | 1 |
p.D150N | ESCA | 1 |
p.I512L | BLCA | 1 |
p.D188N | SKCM | 1 |
p.Q528L | BLCA | 1 |
p.R286H | COAD | 1 |
p.C83* | LUAD | 1 |
p.T187S | HNSC | 1 |
p.A47S | HNSC | 1 |
p.G552E | COAD | 1 |
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TissGeneCNV for CFHR4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CFHR4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AV661668 | SETDB1-CFHR4 | chr1:150917580 | chr1:196801204 |
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TissGeneNet for CFHR4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CFHR4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CFHR4 |
TissGeneDrug for CFHR4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CFHR4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C2931788 | Atypical Hemolytic Uremic Syndrome | 1 | GAD |