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| TissGeneSummary for ACTL7B |
 Gene summary |
| Basic gene information | Gene symbol | ACTL7B |
| Gene name | actin-like 7B | |
| Synonyms | Tact1 | |
| Cytomap | UCSC genome browser: 9q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006686.3, | |
| Description | actin-like 7-betaactin-like protein 7Bactin-like-7-beta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604304 | |
| HGNC : HGNC | ||
| HPRD : 11977 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACTL7B | |
| BioGPS: 10880 | ||
| Pathway | NCI Pathway Interaction Database: ACTL7B | |
| KEGG: ACTL7B | ||
| REACTOME: ACTL7B | ||
| Pathway Commons: ACTL7B | ||
| Context | iHOP: ACTL7B | |
| ligand binding site mutation search in PubMed: ACTL7B | ||
| UCL Cancer Institute: ACTL7B | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ACTL7B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ACTL7B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ACTL7B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ACTL7B |
| TissGeneSNV for ACTL7B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P142L | SKCM | 2 |
| p.E211K | CESC | 2 |
| p.R135H | CESC | 1 |
| p.R221C | SARC | 1 |
| p.D285E | LUSC | 1 |
| p.P26S | SKCM | 1 |
| p.T219I | SKCM | 1 |
| p.M347V | GBM | 1 |
| p.R221S | LUAD | 1 |
| p.A262V | UVM | 1 |
| p.C415Y | UCEC | 1 |
| p.G99A | LUAD | 1 |
| p.E144K | STAD | 1 |
| p.R135H | BLCA | 1 |
| p.S193L | LGG | 1 |
| p.Q235L | LUAD | 1 |
| p.D366E | LUAD | 1 |
| p.S77F | HNSC | 1 |
| p.P153S | SKCM | 1 |
| p.D91N | PAAD | 1 |
| p.G226E | LGG | 1 |
| p.T329M | HNSC | 1 |
| p.D280Y | LUAD | 1 |
| p.K116N | STAD | 1 |
| p.E85K | PAAD | 1 |
| p.R82H | READ | 1 |
| p.E85K | PRAD | 1 |
| p.R354H | PRAD | 1 |
| p.C322Y | STAD | 1 |
| p.H47N | STAD | 1 |
| p.P43L | SKCM | 1 |
| p.R376S | THYM | 1 |
| p.A13S | BLCA | 1 |
| p.P284L | COAD | 1 |
| p.D228H | SKCM | 1 |
| p.G194R | SKCM | 1 |
| p.G227A | BRCA | 1 |
| p.S188F | SKCM | 1 |
| p.G18E | UCEC | 1 |
| p.P305S | SKCM | 1 |
| p.P7L | HNSC | 1 |
| p.G57D | KIRC | 1 |
| p.A146V | UCEC | 1 |
| p.V126M | CESC | 1 |
| p.M41I | LUAD | 1 |
| p.S182L | SKCM | 1 |
| p.R354C | PRAD | 1 |
| p.S182L | UCEC | 1 |
| p.G241D | STAD | 1 |
| p.D223N | SKCM | 1 |
| p.S180F | SKCM | 1 |
| p.K256N | UCEC | 1 |
| p.P313S | LGG | 1 |
| p.E282K | SKCM | 1 |
| p.L390M | COAD | 1 |
| p.Y132H | STAD | 1 |
| p.V79M | BLCA | 1 |
| p.G271D | COAD | 1 |
| p.G286V | BLCA | 1 |
| p.R406W | SKCM | 1 |
| p.G212A | HNSC | 1 |
| p.R295C | READ | 1 |
| p.A28T | MESO | 1 |
| p.V120M | COAD | 1 |
| p.P156L | SKCM | 1 |
| p.K256R | STAD | 1 |
| p.A2V | GBM | 1 |
| p.T319A | PRAD | 1 |
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| TissGeneCNV for ACTL7B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ACTL7B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ACTL7B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ACTL7B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ACTL7B |
| TissGeneDrug for ACTL7B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ACTL7B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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