TissGeneSummary for PRSS21 |
Gene summary |
Basic gene information | Gene symbol | PRSS21 |
Gene name | protease, serine, 21 (testisin) | |
Synonyms | ESP-1|ESP1|TEST1|TESTISIN | |
Cytomap | UCSC genome browser: 16p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001270452.1, NM_006799.3,NM_144956.2,NM_144957.2,NR_073012.1, | |
Description | eosinophil serine protease 1serine protease from eosinophilstestisin | |
Modification date | 20141207 | |
dbXrefs | MIM : 608159 | |
HGNC : HGNC | ||
Ensembl : ENSG00000007038 | ||
HPRD : 07082 | ||
Vega : OTTHUMG00000128931 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRSS21 | |
BioGPS: 10942 | ||
Pathway | NCI Pathway Interaction Database: PRSS21 | |
KEGG: PRSS21 | ||
REACTOME: PRSS21 | ||
Pathway Commons: PRSS21 | ||
Context | iHOP: PRSS21 | |
ligand binding site mutation search in PubMed: PRSS21 | ||
UCL Cancer Institute: PRSS21 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of PRSS21 | Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis. Manton KJ, Douglas ML, Netzel-Arnett S, Fitzpatrick DR, Nicol DL, Boyd AW, Clements JA, Antalis TM. Br J Cancer. 2005 Feb 28;92(4):760-9. Erratum in: Br J Cancer. 2015 Dec 1;113(11):1640 (pmid:15685234) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for PRSS21 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 0.547597972 | 1.548371049 | -1.000773077 | 0.0178 | 0.03984995 |
STAD | 1.34499076 | -0.39888424 | 1.743875 | 0.012 | 0.03945614 |
LUAD | 0.927022441 | 2.206831062 | -1.279808621 | 0.00293 | 0.005894161 |
Top |
TissGene-miRNA for PRSS21 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for PRSS21 |
TissGeneSNV for PRSS21 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P301S | SKCM | 2 |
p.G228R | LGG | 1 |
p.W250C | STAD | 1 |
p.P54S | UCEC | 1 |
p.P186S | COAD | 1 |
p.G259R | SKCM | 1 |
p.P303L | COAD | 1 |
p.G257R | SKCM | 1 |
p.Q252H | UCEC | 1 |
p.C33X | LIHC | 1 |
p.G177V | KIRP | 1 |
p.Q252H | ESCA | 1 |
p.V121A | ESCA | 1 |
p.V256M | UCEC | 1 |
p.D220N | BLCA | 1 |
p.W278* | BLCA | 1 |
p.G175V | KIRP | 1 |
p.P241R | OV | 1 |
p.G95W | STAD | 1 |
p.G173C | SKCM | 1 |
p.Q100E | KIRP | 1 |
p.R267W | PAAD | 1 |
p.E279Q | ESCA | 1 |
p.S89T | LUAD | 1 |
p.S122L | STAD | 1 |
p.P198S | SKCM | 1 |
p.S294F | SKCM | 1 |
p.P307S | LUAD | 1 |
p.R186C | SKCM | 1 |
p.N199T | SKCM | 1 |
p.R214H | STAD | 1 |
p.A222S | KIRC | 1 |
p.S91T | LUAD | 1 |
p.S91I | THYM | 1 |
p.E277Q | ESCA | 1 |
p.C244Y | COAD | 1 |
p.A195T | PRAD | 1 |
p.R264W | UCEC | 1 |
p.G246E | SKCM | 1 |
p.Q102E | KIRP | 1 |
p.G51R | COAD | 1 |
p.T188N | LUAD | 1 |
p.D137G | UCEC | 1 |
p.D218N | BLCA | 1 |
p.R4C | STAD | 1 |
p.S111N | UCEC | 1 |
Top |
TissGeneCNV for PRSS21 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for PRSS21 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW379529 | FAM20B-PRSS21 | chr1:179013356 | chr16:2867851 |
Top |
TissGeneNet for PRSS21 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for PRSS21 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for PRSS21 |
TissGeneDrug for PRSS21 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for PRSS21 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 2 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0009917 | Contracture | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0023787 | Lipodystrophy | 1 | BeFree |
umls:C0024591 | Malignant hyperpyrexia due to anesthesia | 1 | BeFree |
umls:C0039538 | Teratoma | 1 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C1270972 | Mild cognitive disorder | 1 | BeFree |
umls:C1280433 | Lipoatrophy | 1 | BeFree |