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| TissGeneSummary for SLC27A5 |
 Gene summary |
| Basic gene information | Gene symbol | SLC27A5 |
| Gene name | solute carrier family 27 (fatty acid transporter), member 5 | |
| Synonyms | ACSB|ACSVL6|BACS|BAL|FACVL3|FATP-5|FATP5|VLACSR|VLCS-H2|VLCSH2 | |
| Cytomap | UCSC genome browser: 19q13.43 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012254.2, | |
| Description | BA-CoA ligaseVLACS-relatedbile acid-CoA ligasebile acyl-CoA synthetasecholate--CoA ligasefatty acid transport protein 5fatty-acid-Coenzyme A ligase, very long-chain 3solute carrier family 27 member 5very long-chain acyl-CoA synthetase homolog 2ve | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603314 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000083807 | ||
| HPRD : 04499 | ||
| Vega : OTTHUMG00000183543 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC27A5 | |
| BioGPS: 10998 | ||
| Pathway | NCI Pathway Interaction Database: SLC27A5 | |
| KEGG: SLC27A5 | ||
| REACTOME: SLC27A5 | ||
| Pathway Commons: SLC27A5 | ||
| Context | iHOP: SLC27A5 | |
| ligand binding site mutation search in PubMed: SLC27A5 | ||
| UCL Cancer Institute: SLC27A5 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of SLC27A5 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000038 | very long-chain fatty acid metabolic process | 10479480 | GO:0006699 | bile acid biosynthetic process | 11980911 | GO:0000038 | very long-chain fatty acid metabolic process | 10479480 | GO:0006699 | bile acid biosynthetic process | 11980911 |
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| TissGeneExp for SLC27A5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 1.576630335 | 0.27544572 | 1.301184615 | 4.53E-06 | 2.24E-05 |
| LIHC | 6.73193372 | 9.20817772 | -2.476244 | 2.12E-09 | 2.15E-08 |
| KIRC | -0.103533447 | 0.956279053 | -1.0598125 | 2.44E-15 | 1.25E-14 |
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| TissGene-miRNA for SLC27A5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC27A5 |
| TissGeneSNV for SLC27A5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T554I | SKCM | 13 |
| p.E566K | BLCA | 2 |
| p.V536I | DLBC | 1 |
| p.A28T | COAD | 1 |
| p.D398N | BLCA | 1 |
| p.R689M | LGG | 1 |
| p.P588Q | LUAD | 1 |
| p.F362L | UCEC | 1 |
| p.R387Q | COAD | 1 |
| p.R550C | SKCM | 1 |
| p.R556X | ESCA | 1 |
| p.N391S | SKCM | 1 |
| p.R387Q | DLBC | 1 |
| p.V585M | BRCA | 1 |
| p.R509C | KIRC | 1 |
| p.G141S | CESC | 1 |
| p.N205K | STAD | 1 |
| p.E610D | KIRC | 1 |
| p.K317N | CESC | 1 |
| p.C590S | CESC | 1 |
| p.R509H | LUSC | 1 |
| p.R387Q | UCEC | 1 |
| p.R447C | LIHC | 1 |
| p.G348D | OV | 1 |
| p.G552R | HNSC | 1 |
| p.Y432C | SKCM | 1 |
| p.A263V | LGG | 1 |
| p.R311Q | BRCA | 1 |
| p.S182F | LUAD | 1 |
| p.P425S | BLCA | 1 |
| p.L519M | SARC | 1 |
| p.P603A | ACC | 1 |
| p.A682D | LGG | 1 |
| p.R311Q | CESC | 1 |
| p.A473E | HNSC | 1 |
| p.V529F | LUSC | 1 |
| p.Y546C | LGG | 1 |
| p.R617C | READ | 1 |
| p.K558N | BLCA | 1 |
| p.A602T | LUSC | 1 |
| p.S168I | ESCA | 1 |
| p.F663Y | CHOL | 1 |
| p.R387W | PRAD | 1 |
| p.E566* | BLCA | 1 |
| p.G604D | STAD | 1 |
| p.R459Q | BLCA | 1 |
| p.A324S | LUSC | 1 |
| p.A474V | LIHC | 1 |
| p.G552R | LUAD | 1 |
| p.M50T | COAD | 1 |
| p.G488W | PAAD | 1 |
| p.L75F | READ | 1 |
| p.R422C | READ | 1 |
| p.G164R | CESC | 1 |
| p.A359V | UCEC | 1 |
| p.A669G | DLBC | 1 |
| p.R550C | STAD | 1 |
| p.R517Q | LUAD | 1 |
| p.G345V | SARC | 1 |
| p.D414V | STAD | 1 |
| p.G260E | SKCM | 1 |
| p.V24M | COAD | 1 |
| p.T308A | COAD | 1 |
| p.R447C | HNSC | 1 |
| p.R53W | COAD | 1 |
| p.G552E | HNSC | 1 |
| p.V376M | PAAD | 1 |
| p.R125* | UCEC | 1 |
| p.S515* | SARC | 1 |
| p.L461P | STAD | 1 |
| p.F367Y | PRAD | 1 |
| p.E566K | CESC | 1 |
| p.I392T | BLCA | 1 |
| p.T325A | LUAD | 1 |
| p.L37R | DLBC | 1 |
| p.L37R | KIRP | 1 |
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| TissGeneCNV for SLC27A5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC27A5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA285853 | SNHG1-SLC27A5 | chr11:62621436 | chr19:59022932 | |
| Chimerdb3.0 | ChiTaRs | NA | AA457551 | SLC27A5-ESRRG | chr19:59015502 | chr1:216730758 |
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| TissGeneNet for SLC27A5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC27A5, NR1H4, HSF4 (tumor) | SLC27A5, NR1H4, HSF4 (normal) |
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| TissGeneProg for SLC27A5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC27A5 |
| TissGeneDrug for SLC27A5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC27A5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 6 | BeFree |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0032285 | Pneumonia | 3 | BeFree |
| umls:C0036202 | Sarcoidosis | 3 | BeFree |
| umls:C1701940 | Pneumonia, Ventilator-Associated | 3 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 2 | BeFree |
| umls:C0034050 | Pulmonary Alveolar Proteinosis | 2 | BeFree |
| umls:C0036205 | Sarcoidosis, Pulmonary | 2 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 2 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 2 | BeFree |
| umls:C0085669 | Acute leukemia | 2 | BeFree |
| umls:C0276653 | Invasive Pulmonary Aspergillosis | 2 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
| umls:C1535939 | Pneumocystis jiroveci pneumonia | 2 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 2 | BeFree |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0015695 | Fatty Liver | 1 | BeFree,GAD |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0022521 | Kartagener Syndrome | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0024314 | Lymphoproliferative Disorders | 1 | BeFree |
| umls:C0026936 | Mycoplasma Infections | 1 | BeFree |
| umls:C0034063 | Pulmonary Edema | 1 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
| umls:C0035204 | Respiration Disorders | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0043144 | Wheezing | 1 | BeFree |
| umls:C0085605 | Liver Failure | 1 | BeFree |
| umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
| umls:C0206062 | Lung Diseases, Interstitial | 1 | BeFree |
| umls:C0242459 | Simple Pulmonary Eosinophilia | 1 | BeFree |
| umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
| umls:C0264219 | Acute respiratory disease | 1 | BeFree |
| umls:C0275524 | Coinfection | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree,GAD |
| umls:C0553694 | Oropharyngeal disorders | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |
| umls:C3714636 | Pneumonitis | 1 | BeFree |
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