TissGeneSummary for KIF2C |
Gene summary |
Basic gene information | Gene symbol | KIF2C |
Gene name | kinesin family member 2C | |
Synonyms | CT139|KNSL6|MCAK | |
Cytomap | UCSC genome browser: 1p34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001297655.1, NM_001297656.1,NM_001297657.1,NM_006845.3, | |
Description | kinesin-like protein 6kinesin-like protein KIF2Cmitotic centromere-associated kinesin | |
Modification date | 20141207 | |
dbXrefs | MIM : 604538 | |
HGNC : HGNC | ||
Ensembl : ENSG00000142945 | ||
HPRD : 05172 | ||
Vega : OTTHUMG00000008416 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIF2C | |
BioGPS: 11004 | ||
Pathway | NCI Pathway Interaction Database: KIF2C | |
KEGG: KIF2C | ||
REACTOME: KIF2C | ||
Pathway Commons: KIF2C | ||
Context | iHOP: KIF2C | |
ligand binding site mutation search in PubMed: KIF2C | ||
UCL Cancer Institute: KIF2C | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIF2C | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007019 | microtubule depolymerization | 21820309 | GO:0007019 | microtubule depolymerization | 21820309 |
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TissGeneExp for KIF2C |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 0.550533125 | -3.361388875 | 3.911922 | 2.30E-25 | 5.33E-23 |
STAD | 2.68651375 | 0.178904375 | 2.507609375 | 1.12E-08 | 5.25E-07 |
LUAD | 1.753566229 | -1.99889584 | 3.752462069 | 5.98E-29 | 5.16E-27 |
KIRP | -0.627908125 | -2.365970625 | 1.7380625 | 9.31E-07 | 4.79E-06 |
LUSC | 3.03711038 | -1.606058247 | 4.643168627 | 1.05E-38 | 4.73E-36 |
COAD | 2.883980818 | 1.430053894 | 1.453926923 | 2.35E-11 | 4.15E-10 |
HNSC | 3.06573359 | 1.234787079 | 1.830946512 | 8.74E-12 | 2.34E-10 |
KIRC | -0.318326875 | -2.089485208 | 1.771158333 | 2.35E-19 | 1.73E-18 |
BLCA | 3.323867862 | -0.199211085 | 3.523078947 | 3.98E-07 | 1.64E-05 |
BRCA | 1.977421371 | -1.382158454 | 3.359579825 | 1.98E-49 | 1.21E-47 |
ESCA | 2.718709489 | -0.602808693 | 3.321518182 | 7.11E-05 | 0.002470725 |
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TissGene-miRNA for KIF2C |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KIF2C |
TissGeneSNV for KIF2C |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A500T | STAD | 2 |
p.A500T | UCEC | 2 |
p.I701M | LUSC | 1 |
p.P12S | SKCM | 1 |
p.Q167E | BLCA | 1 |
p.A614V | READ | 1 |
p.S685C | LUSC | 1 |
p.I553M | LUSC | 1 |
p.K338R | LGG | 1 |
p.D312H | HNSC | 1 |
p.E55* | UCEC | 1 |
p.R177* | UCEC | 1 |
p.Y405C | LUSC | 1 |
p.Q717H | UCEC | 1 |
p.P47S | SKCM | 1 |
p.A346V | SKCM | 1 |
p.L18F | LUAD | 1 |
p.E624Q | ESCA | 1 |
p.A418V | PRAD | 1 |
p.W230R | UCEC | 1 |
p.L706M | LUSC | 1 |
p.L362F | STAD | 1 |
p.R580T | BRCA | 1 |
p.R42* | UCEC | 1 |
p.L620F | CESC | 1 |
p.S574F | SKCM | 1 |
p.V41I | SARC | 1 |
p.K52N | ESCA | 1 |
p.S187P | UCEC | 1 |
p.S181A | STAD | 1 |
p.P228L | SKCM | 1 |
p.R425Q | SKCM | 1 |
p.R93Q | BRCA | 1 |
p.A292V | SKCM | 1 |
p.P174L | SKCM | 1 |
p.I205T | ESCA | 1 |
p.S450N | SKCM | 1 |
p.P101S | SKCM | 1 |
p.S127A | STAD | 1 |
p.S628F | SKCM | 1 |
p.P47L | SKCM | 1 |
p.E569K | SKCM | 1 |
p.A614V | COAD | 1 |
p.R479Q | SKCM | 1 |
p.S470F | SKCM | 1 |
p.A614V | UCEC | 1 |
p.R121C | UCEC | 1 |
p.R644* | PRAD | 1 |
p.A46E | KIRP | 1 |
p.A124T | COAD | 1 |
p.R479Q | UCEC | 1 |
p.D59H | CESC | 1 |
p.S187L | UCEC | 1 |
p.C526Y | UCEC | 1 |
p.L243F | THYM | 1 |
p.D258H | HNSC | 1 |
p.S228F | SKCM | 1 |
p.A472V | PRAD | 1 |
p.F382L | UCEC | 1 |
p.L273F | THYM | 1 |
p.D5H | CESC | 1 |
p.P184H | STAD | 1 |
p.A16T | BLCA | 1 |
p.G500A | LUAD | 1 |
p.E613* | LUAD | 1 |
p.D74N | BLCA | 1 |
p.E458Q | BLCA | 1 |
p.E525G | LIHC | 1 |
p.T521I | ACC | 1 |
p.D621E | LUAD | 1 |
p.T524S | LUAD | 1 |
p.P101L | SKCM | 1 |
p.E170Q | CESC | 1 |
p.E570Q | ESCA | 1 |
p.V700L | STAD | 1 |
p.D583N | COAD | 1 |
p.A509V | LGG | 1 |
p.E677D | UCEC | 1 |
p.E667* | LUAD | 1 |
p.R189L | PAAD | 1 |
p.R59C | SKCM | 1 |
p.P101S | LUSC | 1 |
p.R456L | LUAD | 1 |
p.D450N | UCEC | 1 |
p.T343N | READ | 1 |
p.T575I | ACC | 1 |
p.R266C | UCEC | 1 |
p.N158K | SKCM | 1 |
p.R140H | STAD | 1 |
p.L566F | CESC | 1 |
p.I56M | OV | 1 |
p.L15F | SKCM | 1 |
p.L308F | STAD | 1 |
p.S416F | SKCM | 1 |
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TissGeneCNV for KIF2C |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KIF2C |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AU123804 | KIF2C-LYPD6B | chr1:45225989 | chr2:150005596 | |
Chimerdb3.0 | ChiTaRs | NA | CN388633 | KIF2C-CHTF8 | chr1:45233407 | chr16:69154359 |
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TissGeneNet for KIF2C |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KIF2C |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KIF2C |
TissGeneDrug for KIF2C |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KIF2C |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010068 | Coronary heart disease | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree,GAD |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 3 | BeFree |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | LHGDN |
umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C1956346 | Coronary Artery Disease | 2 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |