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| TissGeneSummary for ZPBP |
 Gene summary |
| Basic gene information | Gene symbol | ZPBP |
| Gene name | zona pellucida binding protein | |
| Synonyms | ZPBP1 | |
| Cytomap | UCSC genome browser: 7p14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001159878.1, NM_007009.2, | |
| Description | zona pellucida binding protein 1zona pellucida-binding protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608498 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000042813 | ||
| HPRD : 18364 | ||
| Vega : OTTHUMG00000023528 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZPBP | |
| BioGPS: 11055 | ||
| Pathway | NCI Pathway Interaction Database: ZPBP | |
| KEGG: ZPBP | ||
| REACTOME: ZPBP | ||
| Pathway Commons: ZPBP | ||
| Context | iHOP: ZPBP | |
| ligand binding site mutation search in PubMed: ZPBP | ||
| UCL Cancer Institute: ZPBP | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZPBP | The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis. Microsc Res Tech. 2009 Aug;72(8):558-65. doi: 10.1002/jemt.20696. (pmid:19204925) go to article | |
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZPBP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZPBP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZPBP |
| TissGeneSNV for ZPBP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G333R | SKCM | 3 |
| p.R154C | GBM | 2 |
| p.V219I | UCEC | 2 |
| p.G332R | SKCM | 2 |
| p.R258I | UCEC | 2 |
| p.R154C | STAD | 1 |
| p.A72E | ESCA | 1 |
| p.R115H | LIHC | 1 |
| p.C320Y | THYM | 1 |
| p.R331H | STAD | 1 |
| p.L212I | LUAD | 1 |
| p.M75I | HNSC | 1 |
| p.L197I | SKCM | 1 |
| p.F303V | STAD | 1 |
| p.Q101* | SKCM | 1 |
| p.R54C | ACC | 1 |
| p.Q196H | SARC | 1 |
| p.S99L | HNSC | 1 |
| p.G44A | HNSC | 1 |
| p.L125F | SKCM | 1 |
| p.R115H | ESCA | 1 |
| p.D240Y | UCEC | 1 |
| p.G292D | LGG | 1 |
| p.N187Y | LUAD | 1 |
| p.E143K | GBM | 1 |
| p.A160V | BLCA | 1 |
| p.L239Q | LUSC | 1 |
| p.P245T | LUSC | 1 |
| p.P181L | SKCM | 1 |
| p.E143K | SKCM | 1 |
| p.S210C | LUAD | 1 |
| p.R91* | GBM | 1 |
| p.R165H | LIHC | 1 |
| p.R91Q | READ | 1 |
| p.R48* | UCS | 1 |
| p.P304Q | ESCA | 1 |
| p.Q273H | BLCA | 1 |
| p.S214C | BLCA | 1 |
| p.R279C | COAD | 1 |
| p.P98T | PRAD | 1 |
| p.I161L | LUSC | 1 |
| p.S237L | SKCM | 1 |
| p.E254D | STAD | 1 |
| p.H178N | LUAD | 1 |
| p.G346E | SKCM | 1 |
| p.I96K | LUSC | 1 |
| p.G107V | UCEC | 1 |
| p.H217R | LUAD | 1 |
| p.R218H | BRCA | 1 |
| p.W102* | LUAD | 1 |
| p.R280C | BLCA | 1 |
| p.R115H | UCEC | 1 |
| p.A175T | STAD | 1 |
| p.L155V | LUAD | 1 |
| p.S327L | SKCM | 1 |
| p.E143X | PAAD | 1 |
| p.S99L | BLCA | 1 |
| p.G292S | LUAD | 1 |
| p.R63Q | UCEC | 1 |
| p.G305A | LAML | 1 |
| p.C253R | UCEC | 1 |
| p.E229K | SKCM | 1 |
| p.E282Q | LUAD | 1 |
| p.R91Q | UCEC | 1 |
| p.Q101X | SKCM | 1 |
| p.E274X | READ | 1 |
| p.D58N | BLCA | 1 |
| p.R164H | COAD | 1 |
| p.H335Y | STAD | 1 |
| p.F269Y | UCEC | 1 |
| p.R48* | THCA | 1 |
| p.G345E | SKCM | 1 |
| p.G307R | SKCM | 1 |
| p.G107E | SKCM | 1 |
| p.R247L | STAD | 1 |
| p.I276T | STAD | 1 |
| p.I137T | GBM | 1 |
| p.E275D | STAD | 1 |
| p.P81S | SKCM | 1 |
| p.S326L | SKCM | 1 |
| p.L205I | LUAD | 1 |
| p.R48L | LUAD | 1 |
| p.G292S | LGG | 1 |
| p.L198I | SKCM | 1 |
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| TissGeneCNV for ZPBP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZPBP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI049509 | ZPBP-LUM | chr7:50087275 | chr12:91497325 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-ZG-A8QX-01A | GRB10-ZPBP | Out-of-Frame | chr7:50799968 | chr7:49977218 |
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| TissGeneNet for ZPBP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| COAD (tumor) | COAD (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| KICH (tumor) | KICH (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| STAD (tumor) | STAD (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| THCA (tumor) | THCA (normal) |
| ZPBP, ZP2, CALU (tumor) | ZPBP, ZP2, CALU (normal) |
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| TissGeneProg for ZPBP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZPBP |
| TissGeneDrug for ZPBP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZPBP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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