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| TissGeneSummary for ADAM30 |
 Gene summary |
| Basic gene information | Gene symbol | ADAM30 |
| Gene name | ADAM metallopeptidase domain 30 | |
| Synonyms | svph4 | |
| Cytomap | UCSC genome browser: 1p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021794.3, | |
| Description | a disintegrin and metalloproteinase domain 30disintegrin and metalloproteinase domain-containing protein 30 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604779 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134249 | ||
| HPRD : 05307 | ||
| Vega : OTTHUMG00000189303 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADAM30 | |
| BioGPS: 11085 | ||
| Pathway | NCI Pathway Interaction Database: ADAM30 | |
| KEGG: ADAM30 | ||
| REACTOME: ADAM30 | ||
| Pathway Commons: ADAM30 | ||
| Context | iHOP: ADAM30 | |
| ligand binding site mutation search in PubMed: ADAM30 | ||
| UCL Cancer Institute: ADAM30 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ADAM30 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ADAM30 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ADAM30 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ADAM30 |
| TissGeneSNV for ADAM30 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E754K | KIRC | 3 |
| p.R134Q | SKCM | 2 |
| p.G540E | SKCM | 2 |
| p.H578D | BLCA | 2 |
| p.G403E | SKCM | 2 |
| p.E663K | SKCM | 1 |
| p.A190T | BLCA | 1 |
| p.P566L | SKCM | 1 |
| p.R542* | SKCM | 1 |
| p.D258N | SKCM | 1 |
| p.G36E | SKCM | 1 |
| p.M113I | BRCA | 1 |
| p.N561H | KIRC | 1 |
| p.M605I | SKCM | 1 |
| p.K620X | COAD | 1 |
| p.K736I | KIRC | 1 |
| p.V624I | LUSC | 1 |
| p.G97R | LUAD | 1 |
| p.R245C | BLCA | 1 |
| p.L325P | LUAD | 1 |
| p.R542X | SKCM | 1 |
| p.R356K | SKCM | 1 |
| p.P185S | SKCM | 1 |
| p.E460K | SKCM | 1 |
| p.E47Q | BLCA | 1 |
| p.L443F | BLCA | 1 |
| p.V74I | READ | 1 |
| p.F631S | READ | 1 |
| p.G767E | BLCA | 1 |
| p.E206Q | GBM | 1 |
| p.G369E | SKCM | 1 |
| p.G486R | SKCM | 1 |
| p.P674T | UCEC | 1 |
| p.H33N | CHOL | 1 |
| p.K280I | STAD | 1 |
| p.P393T | HNSC | 1 |
| p.G345E | SKCM | 1 |
| p.W78X | STAD | 1 |
| p.A764S | CHOL | 1 |
| p.S314Y | READ | 1 |
| p.D258Y | UCEC | 1 |
| p.Q67* | LGG | 1 |
| p.Y375H | HNSC | 1 |
| p.C110G | LIHC | 1 |
| p.D465E | LUAD | 1 |
| p.R425W | SKCM | 1 |
| p.A437G | OV | 1 |
| p.L49M | SARC | 1 |
| p.S762Y | BLCA | 1 |
| p.L305I | BLCA | 1 |
| p.Q759R | LIHC | 1 |
| p.R494C | UCEC | 1 |
| p.R134Q | BLCA | 1 |
| p.E411K | SKCM | 1 |
| p.H33Y | KIRC | 1 |
| p.R263C | GBM | 1 |
| p.W687R | LUAD | 1 |
| p.A755T | UCEC | 1 |
| p.D177G | READ | 1 |
| p.S308L | COAD | 1 |
| p.D177H | CESC | 1 |
| p.P153L | LUAD | 1 |
| p.Q768* | STAD | 1 |
| p.G472E | SKCM | 1 |
| p.R425Q | LUSC | 1 |
| p.T368N | UCEC | 1 |
| p.C353Y | CESC | 1 |
| p.E734K | BRCA | 1 |
| p.Q242K | LUAD | 1 |
| p.D608Y | BLCA | 1 |
| p.A437P | LUSC | 1 |
| p.C618S | SARC | 1 |
| p.R709W | GBM | 1 |
| p.R451C | STAD | 1 |
| p.G168A | LGG | 1 |
| p.V90I | STAD | 1 |
| p.R458K | STAD | 1 |
| p.S122A | BRCA | 1 |
| p.G97A | LUAD | 1 |
| p.W78* | STAD | 1 |
| p.G396D | LUAD | 1 |
| p.S92F | SKCM | 1 |
| p.S611F | SKCM | 1 |
| p.R641W | THYM | 1 |
| p.V159I | OV | 1 |
| p.R695C | READ | 1 |
| p.G680E | KIRP | 1 |
| p.H103Y | SKCM | 1 |
| p.A681V | PAAD | 1 |
| p.L433F | GBM | 1 |
| p.G394R | OV | 1 |
| p.P34L | SKCM | 1 |
| p.R503K | SKCM | 1 |
| p.G36R | SKCM | 1 |
| p.E316K | SKCM | 1 |
| p.R263C | ACC | 1 |
| p.T572M | PRAD | 1 |
| p.Q67H | LUAD | 1 |
| p.E743* | BLCA | 1 |
| p.W181C | LIHC | 1 |
| p.E492K | SKCM | 1 |
| p.N543D | LGG | 1 |
| p.L330V | SKCM | 1 |
| p.E101K | CHOL | 1 |
| p.Q768X | STAD | 1 |
| p.P519S | SKCM | 1 |
| p.S690F | STAD | 1 |
| p.R367S | THYM | 1 |
| p.A252V | OV | 1 |
| p.R86Q | PAAD | 1 |
| p.E721K | SKCM | 1 |
| p.S384L | READ | 1 |
| p.D243N | BLCA | 1 |
| p.G461E | SKCM | 1 |
| p.G36W | LUAD | 1 |
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| TissGeneCNV for ADAM30 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ADAM30 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ADAM30 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ADAM30 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ADAM30 |
| TissGeneDrug for ADAM30 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ADAM30 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
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