TissGeneSummary for ADAMTS8 |
Gene summary |
Basic gene information | Gene symbol | ADAMTS8 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | |
Synonyms | ADAM-TS8|METH2 | |
Cytomap | UCSC genome browser: 11q25 | |
Type of gene | protein-coding | |
RefGenes | NM_007037.4, | |
Description | A disintegrin and metalloproteinase with thrombospondin motifs 8ADAM-TS 8ADAMTS-8METH-2METH-8a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605175 | |
HGNC : HGNC | ||
Ensembl : ENSG00000134917 | ||
HPRD : 05531 | ||
Vega : OTTHUMG00000165656 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAMTS8 | |
BioGPS: 11095 | ||
Pathway | NCI Pathway Interaction Database: ADAMTS8 | |
KEGG: ADAMTS8 | ||
REACTOME: ADAMTS8 | ||
Pathway Commons: ADAMTS8 | ||
Context | iHOP: ADAMTS8 | |
ligand binding site mutation search in PubMed: ADAMTS8 | ||
UCL Cancer Institute: ADAMTS8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
Reference showing the relevant tissue of ADAMTS8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAMTS8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.652566303 | 1.397152928 | -2.049719231 | 2.32E-05 | 9.72E-05 |
BRCA | -1.564692416 | 0.452882145 | -2.017574561 | 1.62E-16 | 9.27E-16 |
LUSC | -1.171437721 | 4.798568162 | -5.970005882 | 1.80E-27 | 5.55E-26 |
LUAD | 0.213770832 | 4.667312212 | -4.453541379 | 1.28E-23 | 4.22E-22 |
BLCA | -1.281918732 | 2.788981268 | -4.0709 | 6.35E-08 | 4.15E-06 |
KIRC | -1.607062884 | 0.461263505 | -2.068326389 | 4.70E-20 | 3.74E-19 |
HNSC | -2.76342167 | -0.676212367 | -2.087209302 | 1.22E-09 | 1.90E-08 |
KIRP | -1.106873995 | 0.51017288 | -1.617046875 | 2.75E-06 | 1.26E-05 |
KICH | -2.712895995 | 0.665648005 | -3.378544 | 1.56E-19 | 1.01E-17 |
ESCA | -0.38946945 | 2.184894186 | -2.574363636 | 0.00419 | 0.035297576 |
STAD | 0.569432255 | 2.12126663 | -1.551834375 | 0.00158 | 0.007576588 |
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TissGene-miRNA for ADAMTS8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAMTS8 |
TissGeneSNV for ADAMTS8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V524M | GBM | 2 |
p.E516K | SKCM | 2 |
p.D312N | SKCM | 2 |
p.Q853H | SKCM | 1 |
p.E858K | CESC | 1 |
p.R163Q | LIHC | 1 |
p.S216C | MESO | 1 |
p.Y572C | BLCA | 1 |
p.R632W | LIHC | 1 |
p.L506I | COAD | 1 |
p.R540W | STAD | 1 |
p.T856S | STAD | 1 |
p.A357V | ESCA | 1 |
p.E483K | BLCA | 1 |
p.G584R | HNSC | 1 |
p.E639K | UCEC | 1 |
p.R620W | STAD | 1 |
p.S819R | SKCM | 1 |
p.M392I | KIRC | 1 |
p.S618Y | HNSC | 1 |
p.G864S | OV | 1 |
p.G665S | STAD | 1 |
p.D621G | PCPG | 1 |
p.P521S | SKCM | 1 |
p.D284N | PRAD | 1 |
p.P558S | SKCM | 1 |
p.E281Q | LUSC | 1 |
p.P429S | SKCM | 1 |
p.G457V | STAD | 1 |
p.P710S | SKCM | 1 |
p.G366_splice | LUSC | 1 |
p.G536R | SKCM | 1 |
p.P429L | SKCM | 1 |
p.T824N | LUAD | 1 |
p.Q590H | BLCA | 1 |
p.I315M | HNSC | 1 |
p.D342N | STAD | 1 |
p.T577M | PAAD | 1 |
p.S406P | HNSC | 1 |
p.L513V | GBM | 1 |
p.N264D | STAD | 1 |
p.P888S | HNSC | 1 |
p.G605E | SKCM | 1 |
p.A473T | STAD | 1 |
p.L382F | SKCM | 1 |
p.D729N | SKCM | 1 |
p.D878N | SKCM | 1 |
p.C844R | SARC | 1 |
p.S283P | THYM | 1 |
p.F798Y | BLCA | 1 |
p.R780Q | ESCA | 1 |
p.V221M | BLCA | 1 |
p.A525V | COAD | 1 |
p.P794S | SKCM | 1 |
p.A431V | PAAD | 1 |
p.T697I | STAD | 1 |
p.R674Q | STAD | 1 |
p.A496D | KIRP | 1 |
p.D336N | SKCM | 1 |
p.S722N | THCA | 1 |
p.V611A | UCEC | 1 |
p.H550Y | KIRP | 1 |
p.A362V | LUSC | 1 |
p.A496T | COAD | 1 |
p.S633R | PRAD | 1 |
p.A362D | SARC | 1 |
p.G545E | HNSC | 1 |
p.P876T | LUAD | 1 |
p.R291C | ESCA | 1 |
p.R45Q | STAD | 1 |
p.Q835* | BLCA | 1 |
p.P436S | SKCM | 1 |
p.E754* | ACC | 1 |
p.R855* | HNSC | 1 |
p.D284N | UCS | 1 |
p.L355F | UCEC | 1 |
p.D459Y | LUSC | 1 |
p.A640T | SKCM | 1 |
p.F806L | UCEC | 1 |
p.G849R | COAD | 1 |
p.R690G | STAD | 1 |
p.V793A | OV | 1 |
p.V524M | STAD | 1 |
p.R674W | COAD | 1 |
p.G481R | LUAD | 1 |
p.T792A | COAD | 1 |
p.D305N | STAD | 1 |
p.E364K | SKCM | 1 |
p.P698L | SKCM | 1 |
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TissGeneCNV for ADAMTS8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAMTS8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADAMTS8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAMTS8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAMTS8 |
TissGeneDrug for ADAMTS8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAMTS8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1333128 | Common Carcinoma | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |