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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ADAMTS8
check button Gene summary
Basic gene informationGene symbolADAMTS8
Gene nameADAM metallopeptidase with thrombospondin type 1 motif, 8
SynonymsADAM-TS8|METH2
CytomapUCSC genome browser: 11q25
Type of geneprotein-coding
RefGenesNM_007037.4,
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 8ADAM-TS 8ADAMTS-8METH-2METH-8a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Modification date20141207
dbXrefs MIM : 605175
HGNC : HGNC
Ensembl : ENSG00000134917
HPRD : 05531
Vega : OTTHUMG00000165656
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADAMTS8
BioGPS: 11095
PathwayNCI Pathway Interaction Database: ADAMTS8
KEGG: ADAMTS8
REACTOME: ADAMTS8
Pathway Commons: ADAMTS8
ContextiHOP: ADAMTS8
ligand binding site mutation search in PubMed: ADAMTS8
UCL Cancer Institute: ADAMTS8
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Lung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSC
Reference showing the relevant tissue of ADAMTS8
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ADAMTS8

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD-0.6525663031.397152928-2.0497192312.32E-059.72E-05
BRCA-1.5646924160.452882145-2.0175745611.62E-169.27E-16
LUSC-1.1714377214.798568162-5.9700058821.80E-275.55E-26
LUAD0.2137708324.667312212-4.4535413791.28E-234.22E-22
BLCA-1.2819187322.788981268-4.07096.35E-084.15E-06
KIRC-1.6070628840.461263505-2.0683263894.70E-203.74E-19
HNSC-2.76342167-0.676212367-2.0872093021.22E-091.90E-08
KIRP-1.1068739950.51017288-1.6170468752.75E-061.26E-05
KICH-2.7128959950.665648005-3.3785441.56E-191.01E-17
ESCA-0.389469452.184894186-2.5743636360.004190.035297576
STAD0.5694322552.12126663-1.5518343750.001580.007576588


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TissGene-miRNA for ADAMTS8

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ADAMTS8
TissGeneSNV for ADAMTS8

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V524MGBM2
p.E516KSKCM2
p.D312NSKCM2
p.Q853HSKCM1
p.E858KCESC1
p.R163QLIHC1
p.S216CMESO1
p.Y572CBLCA1
p.R632WLIHC1
p.L506ICOAD1
p.R540WSTAD1
p.T856SSTAD1
p.A357VESCA1
p.E483KBLCA1
p.G584RHNSC1
p.E639KUCEC1
p.R620WSTAD1
p.S819RSKCM1
p.M392IKIRC1
p.S618YHNSC1
p.G864SOV1
p.G665SSTAD1
p.D621GPCPG1
p.P521SSKCM1
p.D284NPRAD1
p.P558SSKCM1
p.E281QLUSC1
p.P429SSKCM1
p.G457VSTAD1
p.P710SSKCM1
p.G366_spliceLUSC1
p.G536RSKCM1
p.P429LSKCM1
p.T824NLUAD1
p.Q590HBLCA1
p.I315MHNSC1
p.D342NSTAD1
p.T577MPAAD1
p.S406PHNSC1
p.L513VGBM1
p.N264DSTAD1
p.P888SHNSC1
p.G605ESKCM1
p.A473TSTAD1
p.L382FSKCM1
p.D729NSKCM1
p.D878NSKCM1
p.C844RSARC1
p.S283PTHYM1
p.F798YBLCA1
p.R780QESCA1
p.V221MBLCA1
p.A525VCOAD1
p.P794SSKCM1
p.A431VPAAD1
p.T697ISTAD1
p.R674QSTAD1
p.A496DKIRP1
p.D336NSKCM1
p.S722NTHCA1
p.V611AUCEC1
p.H550YKIRP1
p.A362VLUSC1
p.A496TCOAD1
p.S633RPRAD1
p.A362DSARC1
p.G545EHNSC1
p.P876TLUAD1
p.R291CESCA1
p.R45QSTAD1
p.Q835*BLCA1
p.P436SSKCM1
p.E754*ACC1
p.R855*HNSC1
p.D284NUCS1
p.L355FUCEC1
p.D459YLUSC1
p.A640TSKCM1
p.F806LUCEC1
p.G849RCOAD1
p.R690GSTAD1
p.V793AOV1
p.V524MSTAD1
p.R674WCOAD1
p.G481RLUAD1
p.T792ACOAD1
p.D305NSTAD1
p.E364KSKCM1
p.P698LSKCM1


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TissGeneCNV for ADAMTS8

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ADAMTS8

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for ADAMTS8

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for ADAMTS8

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ADAMTS8
TissGeneDrug for ADAMTS8

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ADAMTS8

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0006118Brain Neoplasms1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0017638Glioma1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0278488Carcinoma breast stage IV1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C1333128Common Carcinoma1BeFree
umls:C2239176Liver carcinoma1BeFree