TissGeneSummary for CAPN11 |
Gene summary |
Basic gene information | Gene symbol | CAPN11 |
Gene name | calpain 11 | |
Synonyms | calpain11 | |
Cytomap | UCSC genome browser: 6p12 | |
Type of gene | protein-coding | |
RefGenes | NM_007058.3, | |
Description | CANP 11calcium-activated neutral proteinase 11calpain-11 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604822 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137225 | ||
HPRD : 05315 | ||
Vega : OTTHUMG00000014758 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAPN11 | |
BioGPS: 11131 | ||
Pathway | NCI Pathway Interaction Database: CAPN11 | |
KEGG: CAPN11 | ||
REACTOME: CAPN11 | ||
Pathway Commons: CAPN11 | ||
Context | iHOP: CAPN11 | |
ligand binding site mutation search in PubMed: CAPN11 | ||
UCL Cancer Institute: CAPN11 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CAPN11 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CAPN11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.846730848 | -0.623250456 | -1.223480392 | 1.98E-08 | 6.05E-08 |
KIRC | 0.171136962 | -2.311068593 | 2.482205556 | 9.41E-17 | 5.45E-16 |
LUAD | -1.924431524 | -0.820816007 | -1.103615517 | 1.23E-08 | 5.44E-08 |
BRCA | -0.653108506 | 2.840776582 | -3.493885088 | 1.41E-60 | 5.30E-58 |
THCA | -0.558020712 | -2.110876644 | 1.552855932 | 3.40E-14 | 3.75E-13 |
LIHC | -0.709739593 | -2.240871593 | 1.531132 | 2.57E-11 | 3.73E-10 |
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TissGene-miRNA for CAPN11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CAPN11 |
TissGeneSNV for CAPN11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L303P | STAD | 1 |
p.H543N | LIHC | 1 |
p.E590K | BLCA | 1 |
p.Q592R | LUAD | 1 |
p.Q682R | LIHC | 1 |
p.D433Y | ESCA | 1 |
p.W639* | SKCM | 1 |
p.P321L | SKCM | 1 |
p.W639X | SKCM | 1 |
p.E582X | LIHC | 1 |
p.S45I | UCEC | 1 |
p.R75K | SARC | 1 |
p.S728N | COAD | 1 |
p.A405T | UCEC | 1 |
p.E664K | LUSC | 1 |
p.M646_splice | UCEC | 1 |
p.G125E | PRAD | 1 |
p.N106D | LIHC | 1 |
p.A447T | UCEC | 1 |
p.D130H | LUSC | 1 |
p.Q459K | LUAD | 1 |
p.L621P | LIHC | 1 |
p.S299C | LGG | 1 |
p.G243* | UCEC | 1 |
p.R706G | KICH | 1 |
p.H307Y | SKCM | 1 |
p.M618T | COAD | 1 |
p.G356V | LUAD | 1 |
p.G295E | LGG | 1 |
p.R336K | SKCM | 1 |
p.G609D | SKCM | 1 |
p.N678K | LUAD | 1 |
p.K720N | COAD | 1 |
p.P255T | KIRC | 1 |
p.L638Q | LIHC | 1 |
p.S225T | GBM | 1 |
p.A435T | LGG | 1 |
p.D690N | LUAD | 1 |
p.P523S | SKCM | 1 |
p.M272V | UCEC | 1 |
p.P321S | SKCM | 1 |
p.R537W | COAD | 1 |
p.D344N | SKCM | 1 |
p.K352N | LUAD | 1 |
p.V341A | STAD | 1 |
p.K352N | UCS | 1 |
p.G231E | LUAD | 1 |
p.R537Q | GBM | 1 |
p.R400C | STAD | 1 |
p.R111W | SARC | 1 |
p.A342V | STAD | 1 |
p.G428E | SKCM | 1 |
p.R616C | COAD | 1 |
p.R268Q | SKCM | 1 |
p.G609S | SKCM | 1 |
p.D385Y | LUAD | 1 |
p.G356W | THYM | 1 |
p.D533G | STAD | 1 |
p.F489L | COAD | 1 |
p.R317W | UCEC | 1 |
p.W322R | LUAD | 1 |
p.V245M | LGG | 1 |
p.R454W | ESCA | 1 |
p.G98D | SKCM | 1 |
p.D623N | PAAD | 1 |
p.Q464H | BLCA | 1 |
p.G51V | KICH | 1 |
p.E313K | SKCM | 1 |
p.D718V | LUAD | 1 |
p.E518K | SKCM | 1 |
p.Q247K | LUAD | 1 |
p.M646V | THCA | 1 |
p.L262F | HNSC | 1 |
p.M622L | LUAD | 1 |
p.R400C | UCEC | 1 |
p.R666L | BRCA | 1 |
p.D623N | LUAD | 1 |
p.P160H | KIRP | 1 |
p.K643N | UCEC | 1 |
p.Q450* | OV | 1 |
p.I578M | PRAD | 1 |
p.R597M | ESCA | 1 |
p.F210L | COAD | 1 |
p.R317W | SKCM | 1 |
p.M360K | SKCM | 1 |
p.E545K | COAD | 1 |
p.R401K | SKCM | 1 |
p.K50N | LIHC | 1 |
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TissGeneCNV for CAPN11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CAPN11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CAPN11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CAPN11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CAPN11 |
TissGeneDrug for CAPN11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CAPN11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |