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| TissGeneSummary for IL1RAPL1 |
 Gene summary |
| Basic gene information | Gene symbol | IL1RAPL1 |
| Gene name | interleukin 1 receptor accessory protein-like 1 | |
| Synonyms | IL1R8|IL1RAPL|MRX10|MRX21|MRX34|OPHN4|TIGIRR-2 | |
| Cytomap | UCSC genome browser: Xp22.1-p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014271.3, | |
| Description | IL-1-RAPL-1IL-1RAPL-1IL1RAPL-1X-linked interleukin-1 receptor accessory protein-like 1interleukin 1 receptor-8interleukin-1 receptor accessory protein-like 1mental retardation, X-linked 10oligophrenin-4three immunoglobulin domain-containing IL-1 r | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300206 | |
| HGNC : HGNC | ||
| HPRD : 02193 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IL1RAPL1 | |
| BioGPS: 11141 | ||
| Pathway | NCI Pathway Interaction Database: IL1RAPL1 | |
| KEGG: IL1RAPL1 | ||
| REACTOME: IL1RAPL1 | ||
| Pathway Commons: IL1RAPL1 | ||
| Context | iHOP: IL1RAPL1 | |
| ligand binding site mutation search in PubMed: IL1RAPL1 | ||
| UCL Cancer Institute: IL1RAPL1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of IL1RAPL1 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045920 | negative regulation of exocytosis | 12783849 | GO:0045920 | negative regulation of exocytosis | 12783849 |
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| TissGeneExp for IL1RAPL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -2.253873562 | -1.076593901 | -1.177279661 | 1.41E-07 | 6.01E-07 |
| STAD | -1.489930713 | -0.201733838 | -1.288196875 | 0.000129 | 0.000970304 |
| PRAD | 0.479356066 | -0.681728549 | 1.161084615 | 8.15E-05 | 0.000349888 |
| BLCA | -2.169517719 | -0.310480877 | -1.859036842 | 1.27E-05 | 0.000235266 |
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| TissGene-miRNA for IL1RAPL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| TGCT | hsa-miR-376b-3p | MIMAT0002172 | 0.0011 | -0.26 | 155 |
| TGCT | hsa-miR-376a-3p | MIMAT0000729 | 0.0013 | -0.26 | 155 |
| COAD | hsa-miR-206 | MIMAT0000462 | 0.00032 | -0.27 | 261 |
| COAD | hsa-miR-206 | MIMAT0000462 | 0.00032 | -0.27 | 261 |
| ACC | hsa-miR-378d | MIMAT0018926 | 0.012 | -0.28 | 78 |
| ACC | hsa-miR-378d | MIMAT0018926 | 0.012 | -0.28 | 78 |
| KICH | hsa-miR-374b-5p | MIMAT0004955 | 0.0093 | -0.29 | 89 |
| KICH | hsa-miR-374b-5p | MIMAT0004955 | 0.0093 | -0.29 | 89 |
| KICH | hsa-miR-374b-5p | MIMAT0004955 | 0.0093 | -0.29 | 89 |
| TGCT | hsa-miR-381-3p | MIMAT0000736 | 0.00025 | -0.29 | 155 |
| ACC | hsa-miR-302a-3p | MIMAT0000684 | 0.0056 | -0.31 | 78 |
| ACC | hsa-miR-302a-3p | MIMAT0000684 | 0.0056 | -0.31 | 78 |
| KICH | hsa-miR-497-5p | MIMAT0002820 | 0.0015 | -0.33 | 89 |
| KICH | hsa-miR-497-5p | MIMAT0002820 | 0.0015 | -0.33 | 89 |
| KICH | hsa-miR-497-5p | MIMAT0002820 | 0.0015 | -0.33 | 89 |
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| TissGeneMut for IL1RAPL1 |
| TissGeneSNV for IL1RAPL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S666L | SKCM | 2 |
| p.R50Q | UCEC | 2 |
| p.P48S | HNSC | 1 |
| p.M559I | LUAD | 1 |
| p.R472W | COAD | 1 |
| p.R106W | BRCA | 1 |
| p.P247L | CESC | 1 |
| p.E396Q | BLCA | 1 |
| p.Q111P | LUSC | 1 |
| p.L431I | PRAD | 1 |
| p.G339R | SKCM | 1 |
| p.R497* | SKCM | 1 |
| p.R563K | SKCM | 1 |
| p.G26R | LUAD | 1 |
| p.R661W | UCEC | 1 |
| p.Q42H | STAD | 1 |
| p.D33G | UCEC | 1 |
| p.L431I | LUSC | 1 |
| p.D436N | BLCA | 1 |
| p.T423S | HNSC | 1 |
| p.G503R | SKCM | 1 |
| p.E208K | SKCM | 1 |
| p.G443E | SKCM | 1 |
| p.K39N | UCEC | 1 |
| p.W539X | SKCM | 1 |
| p.P634L | LIHC | 1 |
| p.H350P | OV | 1 |
| p.V694M | STAD | 1 |
| p.T187S | LUAD | 1 |
| p.V347I | OV | 1 |
| p.R95T | LUAD | 1 |
| p.V632I | BLCA | 1 |
| p.G81V | LUAD | 1 |
| p.L259M | UCEC | 1 |
| p.I194F | HNSC | 1 |
| p.R165S | COAD | 1 |
| p.I317M | COAD | 1 |
| p.R472W | STAD | 1 |
| p.N63H | STAD | 1 |
| p.K2* | HNSC | 1 |
| p.R626* | UCEC | 1 |
| p.G400E | UCEC | 1 |
| p.M284I | SKCM | 1 |
| p.R50* | UCEC | 1 |
| p.R497* | UCEC | 1 |
| p.F551L | UCEC | 1 |
| p.K445T | UCEC | 1 |
| p.L329F | HNSC | 1 |
| p.M355I | COAD | 1 |
| p.R620G | HNSC | 1 |
| p.D452E | OV | 1 |
| p.S333P | LGG | 1 |
| p.R207I | LUAD | 1 |
| p.R106Q | COAD | 1 |
| p.W539* | SKCM | 1 |
| p.Q621R | LUAD | 1 |
| p.E396D | BLCA | 1 |
| p.G424V | LUAD | 1 |
| p.R343L | LUAD | 1 |
| p.I317N | LUAD | 1 |
| p.R343* | SKCM | 1 |
| p.S576C | STAD | 1 |
| p.R342P | LUAD | 1 |
| p.E439Q | LUAD | 1 |
| p.V414L | BLCA | 1 |
| p.I320L | ESCA | 1 |
| p.S576T | BLCA | 1 |
| p.E669Q | LUAD | 1 |
| p.E384G | UCEC | 1 |
| p.R554C | COAD | 1 |
| p.R626Q | UCEC | 1 |
| p.L368P | STAD | 1 |
| p.C143Y | HNSC | 1 |
| p.E426X | READ | 1 |
| p.L547F | HNSC | 1 |
| p.G136D | UCEC | 1 |
| p.F611I | COAD | 1 |
| p.L201V | BRCA | 1 |
| p.S301R | LUAD | 1 |
| p.I518M | HNSC | 1 |
| p.G272A | OV | 1 |
| p.A117T | BRCA | 1 |
| p.G311V | LUAD | 1 |
| p.L19X | SKCM | 1 |
| p.H309R | HNSC | 1 |
| p.D404Y | READ | 1 |
| p.E326D | LUSC | 1 |
| p.E570* | LUAD | 1 |
| p.I367T | UCEC | 1 |
| p.R620S | LUSC | 1 |
| p.E312A | OV | 1 |
| p.W552* | SKCM | 1 |
| p.Q571K | LUAD | 1 |
| p.G222V | ESCA | 1 |
| p.X697W | SKCM | 1 |
| p.E184Q | LUAD | 1 |
| p.P241S | HNSC | 1 |
| p.P479S | LUSC | 1 |
| p.K440N | LGG | 1 |
| p.W104L | LUAD | 1 |
| p.R626Q | HNSC | 1 |
| p.P683L | HNSC | 1 |
| p.W696C | BRCA | 1 |
| p.P88T | UCEC | 1 |
| p.G212E | SKCM | 1 |
| p.R207I | HNSC | 1 |
| p.L370M | ESCA | 1 |
| p.L19* | SKCM | 1 |
| p.D328N | LUSC | 1 |
| p.Y444F | LUSC | 1 |
| p.R428C | PRAD | 1 |
| p.E230K | BLCA | 1 |
| p.S18G | STAD | 1 |
| p.R343* | UCEC | 1 |
| p.W552X | SKCM | 1 |
| p.L584V | GBM | 1 |
| p.E86Q | HNSC | 1 |
| p.T215A | HNSC | 1 |
| p.G114S | SARC | 1 |
| p.C118Y | COAD | 1 |
| p.W283L | BRCA | 1 |
| p.D417N | COAD | 1 |
| p.F289C | STAD | 1 |
| p.Q17E | BLCA | 1 |
| p.N340K | UCEC | 1 |
| p.L115F | STAD | 1 |
| p.R50* | CESC | 1 |
| p.Y64S | SKCM | 1 |
| p.E137K | SKCM | 1 |
| p.D415Y | HNSC | 1 |
| p.D199N | SKCM | 1 |
| p.E511K | SKCM | 1 |
| p.D399N | UCEC | 1 |
| p.P88T | COAD | 1 |
| p.R343Q | LUAD | 1 |
| p.E583K | SKCM | 1 |
| p.W104C | LUAD | 1 |
| p.E176Q | LUAD | 1 |
| p.I290T | BLCA | 1 |
| p.E493K | SKCM | 1 |
| p.R451I | UCEC | 1 |
| p.G311R | LUAD | 1 |
| p.V632I | HNSC | 1 |
| p.L10I | UCEC | 1 |
| p.K153T | LGG | 1 |
| p.H7Q | LUSC | 1 |
| p.G212V | LUAD | 1 |
| p.R687M | LUAD | 1 |
| p.R495S | LIHC | 1 |
| p.R495I | UCEC | 1 |
| p.K528T | KIRP | 1 |
| p.D574E | LUAD | 1 |
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| TissGeneCNV for IL1RAPL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IL1RAPL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AF533682 | IL1RAPL1-DMD | chrX:29417425 | chrX:31697504 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ340532 | PKP4-IL1RAPL1 | chr2:159530418 | chrX:29735453 | |
| Chimerdb3.0 | ChiTaRs | NA | DB359358 | IL1RAPL1-IL1RAPL1 | chrX:29705098 | chrX:29714655 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-GM-A2DK-01A | IL1RAPL1-MAGEB10 | CDS-5UTR | ChrX:28807542 | ChrX:27835671 |
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| TissGeneNet for IL1RAPL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| COAD (tumor) | COAD (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| KICH (tumor) | KICH (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| STAD (tumor) | STAD (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| THCA (tumor) | THCA (normal) |
| IL1RAPL1, NCS1 (tumor) | IL1RAPL1, NCS1 (normal) |
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| TissGeneProg for IL1RAPL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IL1RAPL1 |
| TissGeneDrug for IL1RAPL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IL1RAPL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025362 | Mental Retardation | 9 | BeFree |
| umls:C1136249 | Mental Retardation, X-Linked | 9 | BeFree,CTD_human,LHGDN |
| umls:C0004352 | Autistic Disorder | 8 | BeFree,CTD_human,GAD |
| umls:C1510586 | Autism Spectrum Disorders | 3 | BeFree |
| umls:C3714756 | Intellectual Disability | 3 | BeFree |
| umls:C0432072 | Dysmorphic features | 2 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 1 | GWASCAT |
| umls:C0008074 | Child Development Disorders, Pervasive | 1 | CTD_human |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0025202 | melanoma | 1 | CTD_human |
| umls:C0026106 | Mild Mental Retardation | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0036341 | Schizophrenia | 1 | GAD |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0259813 | Drop Attack | 1 | BeFree |
| umls:C0795887 | CHROMOSOME Xp21 DELETION SYNDROME | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C3840214 | High-functioning autism | 1 | BeFree |
| umls:C0796206 | Atkin syndrome | 0 | CTD_human |
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