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| TissGeneSummary for INSL6 |
 Gene summary |
| Basic gene information | Gene symbol | INSL6 |
| Gene name | insulin-like 6 | |
| Synonyms | RIF1 | |
| Cytomap | UCSC genome browser: 9p24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007179.2, | |
| Description | insulin-like peptide 5insulin-like peptide 6insulin-like peptide INSL6relaxin/insulin-like factor 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606414 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120210 | ||
| HPRD : 08401 | ||
| Vega : OTTHUMG00000019489 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_INSL6 | |
| BioGPS: 11172 | ||
| Pathway | NCI Pathway Interaction Database: INSL6 | |
| KEGG: INSL6 | ||
| REACTOME: INSL6 | ||
| Pathway Commons: INSL6 | ||
| Context | iHOP: INSL6 | |
| ligand binding site mutation search in PubMed: INSL6 | ||
| UCL Cancer Institute: INSL6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of INSL6 | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for INSL6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for INSL6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for INSL6 |
| TissGeneSNV for INSL6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E109K | SKCM | 3 |
| p.R6C | SKCM | 2 |
| p.G182E | COAD | 1 |
| p.R18W | UCEC | 1 |
| p.G13R | SKCM | 1 |
| p.D118Y | THYM | 1 |
| p.D118N | HNSC | 1 |
| p.E81K | BLCA | 1 |
| p.G121R | SKCM | 1 |
| p.K146T | COAD | 1 |
| p.F131I | SKCM | 1 |
| p.R63W | STAD | 1 |
| p.R18Q | COAD | 1 |
| p.K120N | LIHC | 1 |
| p.R63L | STAD | 1 |
| p.D118Y | LUAD | 1 |
| p.S51N | SKCM | 1 |
| p.F80L | DLBC | 1 |
| p.C33X | ESCA | 1 |
| p.F198L | UCEC | 1 |
| p.R18Q | HNSC | 1 |
| p.E58K | SKCM | 1 |
| p.E130X | READ | 1 |
| p.R35M | LUAD | 1 |
| p.P88S | SKCM | 1 |
| p.V139L | SKCM | 1 |
| p.S69L | COAD | 1 |
| p.A86T | COAD | 1 |
| p.G164R | SKCM | 1 |
| p.R205S | UCEC | 1 |
| p.S123L | PAAD | 1 |
| p.R6H | GBM | 1 |
| p.G121E | SKCM | 1 |
| p.D25N | KIRC | 1 |
| p.R3Q | STAD | 1 |
| p.S24R | LUAD | 1 |
| p.R151S | STAD | 1 |
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| TissGeneCNV for INSL6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for INSL6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | CESC | TCGA-PN-A8MA-01A | INSL6-CD274 | Out-of-Frame | chr9:5185313 | chr9:5459186 |
| Chimerdb3.0 | TopHat-Fusion | CESC | TCGA-PN-A8MA-01A | INSL6-PDCD1LG2 | In-Frame | chr9:5185313 | chr9:5524628 |
| Chimerdb3.0 | TopHat-Fusion | CESC | TCGA-PN-A8MA-01A | INSL6-PDCD1LG2 | In-Frame | chr9:5185313 | chr9:5544551 |
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| TissGeneNet for INSL6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for INSL6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for INSL6 |
| TissGeneDrug for INSL6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for INSL6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009324 | Ulcerative Colitis | 1 | GAD |
| umls:C0016057 | Fibrosarcoma | 1 | BeFree |
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