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| TissGeneSummary for WIF1 |
 Gene summary |
| Basic gene information | Gene symbol | WIF1 |
| Gene name | WNT inhibitory factor 1 | |
| Synonyms | WIF-1 | |
| Cytomap | UCSC genome browser: 12q14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007191.4, | |
| Description | wnt inhibitory factor 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605186 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000156076 | ||
| HPRD : 05541 | ||
| Vega : OTTHUMG00000168832 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WIF1 | |
| BioGPS: 11197 | ||
| Pathway | NCI Pathway Interaction Database: WIF1 | |
| KEGG: WIF1 | ||
| REACTOME: WIF1 | ||
| Pathway Commons: WIF1 | ||
| Context | iHOP: WIF1 | |
| ligand binding site mutation search in PubMed: WIF1 | ||
| UCL Cancer Institute: WIF1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCUVM | |
| Reference showing the relevant tissue of WIF1 | ||
| Description by TissGene annotations | Cancer gene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for WIF1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 4.152838657 | 9.303611071 | -5.150772414 | 5.49E-18 | 7.51E-17 |
| KICH | -1.881930308 | 0.483349692 | -2.36528 | 1.21E-06 | 4.50E-06 |
| KIRC | -1.723131697 | 0.140332192 | -1.863463889 | 3.38E-20 | 2.72E-19 |
| STAD | -1.491177183 | 1.904279067 | -3.39545625 | 7.41E-08 | 2.14E-06 |
| PRAD | 2.868888923 | 5.142592769 | -2.273703846 | 1.46E-07 | 1.32E-06 |
| BRCA | 0.181463551 | 5.209844253 | -5.028380702 | 7.99E-32 | 1.15E-30 |
| HNSC | -0.075702401 | 3.739127831 | -3.814830233 | 1.18E-07 | 1.13E-06 |
| LUSC | 2.73039126 | 9.006928515 | -6.276537255 | 1.15E-17 | 1.00E-16 |
| ESCA | -0.53514849 | 2.817187874 | -3.352336364 | 0.00428 | 0.035650637 |
| KIRP | -0.782702183 | 0.450772817 | -1.233475 | 0.000893 | 0.002496392 |
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| TissGene-miRNA for WIF1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUSC | hsa-miR-497-5p | MIMAT0002820 | 0.0023 | -0.27 | 128 |
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| TissGeneMut for WIF1 |
| TissGeneSNV for WIF1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.C326W | LIHC | 2 |
| p.F174L | SKCM | 1 |
| p.V147L | LUSC | 1 |
| p.R196H | UCEC | 1 |
| p.V156A | THYM | 1 |
| p.C177F | LUAD | 1 |
| p.H205N | PRAD | 1 |
| p.R217X | LGG | 1 |
| p.M77I | ESCA | 1 |
| p.I55V | UCEC | 1 |
| p.P183T | KIRC | 1 |
| p.L213I | KIRP | 1 |
| p.R370W | ESCA | 1 |
| p.Q169E | BLCA | 1 |
| p.R107P | PAAD | 1 |
| p.P168T | PAAD | 1 |
| p.V119I | THYM | 1 |
| p.G125E | SKCM | 1 |
| p.H333N | SKCM | 1 |
| p.G61R | SKCM | 1 |
| p.M87I | SKCM | 1 |
| p.C214W | COAD | 1 |
| p.I231M | BRCA | 1 |
| p.F236L | GBM | 1 |
| p.P81L | SKCM | 1 |
| p.S105F | SKCM | 1 |
| p.Q44L | LIHC | 1 |
| p.R187Q | UCEC | 1 |
| p.R107H | UCEC | 1 |
| p.C182* | LUSC | 1 |
| p.E342K | COAD | 1 |
| p.P8S | LGG | 1 |
| p.I263T | SARC | 1 |
| p.P117T | LIHC | 1 |
| p.P216L | SKCM | 1 |
| p.C310Y | COAD | 1 |
| p.E311K | BLCA | 1 |
| p.R217* | LGG | 1 |
| p.R369P | LUAD | 1 |
| p.H129D | HNSC | 1 |
| p.E52K | BRCA | 1 |
| p.C209Y | BLCA | 1 |
| p.P201L | SKCM | 1 |
| p.V119I | SARC | 1 |
| p.A352P | BLCA | 1 |
| p.P183T | LUSC | 1 |
| p.I84V | COAD | 1 |
| p.K72R | PRAD | 1 |
| p.P227L | SKCM | 1 |
| p.H333N | ACC | 1 |
| p.K364R | OV | 1 |
| p.E269Q | CESC | 1 |
| p.P117S | SKCM | 1 |
| p.L213P | LIHC | 1 |
| p.F150S | BLCA | 1 |
| p.P168H | LGG | 1 |
| p.R217Q | STAD | 1 |
| p.C250S | LUSC | 1 |
| p.G299C | LUSC | 1 |
| p.D242G | LGG | 1 |
| p.E102K | SKCM | 1 |
| p.G161D | UCEC | 1 |
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| TissGeneCNV for WIF1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for WIF1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | EU263622 | HMGA2-WIF1 | chr12:66232349 | chr12:65445164 | |
| Chimerdb3.0 | ChiTaRs | NA | EU263620 | HMGA2-WIF1 | chr12:66357153 | chr12:65445164 | |
| Chimerdb3.0 | ChiTaRs | NA | EU263623 | HMGA2-WIF1 | chr12:66232350 | chr12:65445164 | |
| Chimerdb3.0 | ChiTaRs | NA | EF058195 | RPSAP52-WIF1 | chr12:66345196 | chr12:65444406 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-78-7158-01A | HMGA2-WIF1 | In-Frame | chr12:66232349 | chr12:65471634 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-HB-A3YV-01A | UTRN-WIF1 | In-Frame | chr6:144809970 | chr12:65471634 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A23V-01A | TSPAN31-WIF1 | In-Frame | chr12:58140914 | chr12:65471634 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E2-A1LI-01A | TCF7L1-WIF1 | In-Frame | chr2:85361572 | chr12:65471633 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1LI-01A | TCF7L1-WIF1 | In-frame | Chr2:85361573 | Chr12:65471634 |
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| TissGeneNet for WIF1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| COAD (tumor) | COAD (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| HNSC (tumor) | HNSC (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| KICH (tumor) | KICH (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| KIRC (tumor) | KIRC (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| KIRP (tumor) | KIRP (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| LIHC (tumor) | LIHC (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| LUAD (tumor) | LUAD (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| LUSC (tumor) | LUSC (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| PRAD (tumor) | PRAD (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| STAD (tumor) | STAD (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| THCA (tumor) | THCA (normal) |
| WIF1, WNT1, RPL37, ICOS (tumor) | WIF1, WNT1, RPL37, ICOS (normal) |
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| TissGeneProg for WIF1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for WIF1 |
| TissGeneDrug for WIF1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for WIF1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 10 | BeFree |
| umls:C0596263 | Carcinogenesis | 10 | BeFree |
| umls:C1527249 | Colorectal Cancer | 10 | BeFree,GAD |
| umls:C0242379 | Malignant neoplasm of lung | 7 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 6 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 6 | BeFree |
| umls:C0029463 | Osteosarcoma | 5 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 5 | BeFree |
| umls:C0684249 | Carcinoma of lung | 5 | BeFree |
| umls:C2239176 | Liver carcinoma | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree |
| umls:C0001430 | Adenoma | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 3 | BeFree,LHGDN |
| umls:C0017636 | Glioblastoma | 3 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 3 | BeFree |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 2 | BeFree,CTD_human |
| umls:C0023487 | Acute Promyelocytic Leukemia | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0025500 | Mesothelioma | 2 | BeFree,LHGDN |
| umls:C0026277 | Mixed Salivary Gland Tumor | 2 | BeFree,LHGDN |
| umls:C0032584 | polyps | 2 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
| umls:C0280100 | Solid tumour | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0346153 | Breast Cancer, Familial | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C0001618 | Tumors of Adrenal Cortex | 1 | BeFree |
| umls:C0003507 | Aortic Valve Stenosis | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | LHGDN |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007873 | Uterine Cervical Neoplasm | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | LHGDN |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0025218 | Chloasma | 1 | BeFree |
| umls:C0027439 | Nasopharyngeal Neoplasms | 1 | CTD_human |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | GAD |
| umls:C0032019 | Pituitary Neoplasms | 1 | LHGDN |
| umls:C0032227 | Pleural effusion disorder | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0034887 | Rectal polyp | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | GAD |
| umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0079541 | Holoprosencephaly | 1 | BeFree |
| umls:C0080032 | Pleural Effusion, Malignant | 1 | BeFree |
| umls:C0151546 | Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0153382 | Malignant neoplasm of oropharynx | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238790 | bone destruction | 1 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
| umls:C0279671 | Cervical Squamous Cell Carcinoma | 1 | BeFree |
| umls:C0279672 | Cervical Adenocarcinoma | 1 | BeFree |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0595989 | Carcinoma of larynx | 1 | BeFree |
| umls:C0677932 | Progressive Neoplastic Disease | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0848558 | Hypospadias | 1 | BeFree |
| umls:C0993582 | Arthritis, Experimental | 1 | BeFree |
| umls:C1266005 | Basaloid squamous cell carcinoma | 1 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1336076 | Sporadic Breast Carcinoma | 1 | BeFree |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1519172 | Salivary Gland Carcinoma ex Pleomorphic Adenoma | 1 | BeFree |
| umls:C1519176 | Salivary Gland Pleomorphic Adenoma | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1691215 | Penile hypospadias | 1 | BeFree |
| umls:C1704421 | Skin Pigmentation Disorder | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C2349952 | Oropharyngeal Carcinoma | 1 | BeFree |
| umls:C2986536 | Bisphosphonate-associated osteonecrosis | 1 | BeFree |
| umls:C3272528 | Small Intestinal Neuroendocrine Tumor | 1 | BeFree |
| umls:C3539781 | Progressive cGVHD | 1 | BeFree |
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