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| TissGeneSummary for DDX20 |
 Gene summary |
| Basic gene information | Gene symbol | DDX20 |
| Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 | |
| Synonyms | DP103|GEMIN3 | |
| Cytomap | UCSC genome browser: 1p21.1-p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007204.4, | |
| Description | DEAD box protein 20DEAD box protein DP 103DEAD-box protein DP103DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kDSMN-interacting proteincomponent of gems 3gemin-3probable ATP-dependent RNA helicase DDX20 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606168 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000064703 | ||
| HPRD : 05859 | ||
| Vega : OTTHUMG00000011956 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DDX20 | |
| BioGPS: 11218 | ||
| Pathway | NCI Pathway Interaction Database: DDX20 | |
| KEGG: DDX20 | ||
| REACTOME: DDX20 | ||
| Pathway Commons: DDX20 | ||
| Context | iHOP: DDX20 | |
| ligand binding site mutation search in PubMed: DDX20 | ||
| UCL Cancer Institute: DDX20 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DDX20 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000387 | spliceosomal snRNP assembly | 18984161 | GO:0000387 | spliceosomal snRNP assembly | 18984161 |
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| TissGeneExp for DDX20 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for DDX20 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DDX20 |
| TissGeneSNV for DDX20 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P700Q | CHOL | 1 |
| p.R343Q | SKCM | 1 |
| p.S148F | BLCA | 1 |
| p.D365N | KIRP | 1 |
| p.L126F | KIRP | 1 |
| p.D122H | STAD | 1 |
| p.Y384H | BLCA | 1 |
| p.I762T | COAD | 1 |
| p.L194H | KIRC | 1 |
| p.Q92E | BLCA | 1 |
| p.Q44E | LUAD | 1 |
| p.C538R | UCEC | 1 |
| p.Q298* | CESC | 1 |
| p.S340L | HNSC | 1 |
| p.R361* | HNSC | 1 |
| p.F315C | KIRP | 1 |
| p.E543K | UCEC | 1 |
| p.E709K | KIRP | 1 |
| p.S400F | BLCA | 1 |
| p.T113S | KIRP | 1 |
| p.C22W | SKCM | 1 |
| p.C538R | STAD | 1 |
| p.A34P | HNSC | 1 |
| p.A426V | GBM | 1 |
| p.M1I | CESC | 1 |
| p.H192Y | SKCM | 1 |
| p.Q408* | SKCM | 1 |
| p.A426P | HNSC | 1 |
| p.R371H | BRCA | 1 |
| p.P308L | SKCM | 1 |
| p.P138S | SKCM | 1 |
| p.E248K | COAD | 1 |
| p.W390R | STAD | 1 |
| p.Q751K | LIHC | 1 |
| p.S685Y | KIRC | 1 |
| p.Y195C | LUAD | 1 |
| p.Q379* | BLCA | 1 |
| p.S714L | SKCM | 1 |
| p.D350H | HNSC | 1 |
| p.R343Q | LUAD | 1 |
| p.D757N | KIRP | 1 |
| p.Q484E | BLCA | 1 |
| p.S8L | BLCA | 1 |
| p.R105G | SKCM | 1 |
| p.E317K | KIRP | 1 |
| p.Q800X | SKCM | 1 |
| p.Q35R | LIHC | 1 |
| p.Y587C | LUAD | 1 |
| p.S322L | SKCM | 1 |
| p.N701H | READ | 1 |
| p.D122N | COAD | 1 |
| p.K215N | SARC | 1 |
| p.D367N | LGG | 1 |
| p.D214H | CESC | 1 |
| p.R801K | PAAD | 1 |
| p.S113L | BLCA | 1 |
| p.I425N | UCEC | 1 |
| p.M154I | BLCA | 1 |
| p.F403L | KIRC | 1 |
| p.P49L | SKCM | 1 |
| p.R371C | SKCM | 1 |
| p.N236S | SARC | 1 |
| p.I39V | LUAD | 1 |
| p.M394V | LIHC | 1 |
| p.R409K | PAAD | 1 |
| p.P287L | SKCM | 1 |
| p.T558N | STAD | 1 |
| p.S172P | KIRC | 1 |
| p.E543K | COAD | 1 |
| p.Y616H | UCEC | 1 |
| p.V381A | BRCA | 1 |
| p.V292A | UCEC | 1 |
| p.R259T | BLCA | 1 |
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| TissGeneCNV for DDX20 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DDX20 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LAML | TCGA-AB-2857-03A | DDX20-TBX15 | In-frame | Chr1:112303470 | Chr1:119428139 |
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| TissGeneNet for DDX20 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DDX20, UBC, SNRPE, SMN1, SUMO2, NCOR1, HDAC2, STXBP3, HDAC5, GSK3B, DHX9, SNRPD3, SIN3A, GEMIN4, SNRPD1, FBL, POLR1E, GIGYF2, BRF2, GAR1, STXBP2 (tumor) | DDX20, SIRT7, GEMIN5, UBC, NCOR1, HDAC2, STXBP3, HDAC5, GSK3B, PTP4A3, SNRPD2, DHX9, SIN3A, SNRPB, PNKP, GIGYF2, PPP4R2, CLN3, STXBP2, ETV3, WRAP53 (normal) |
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| COAD (tumor) | COAD (normal) |
| DDX20, SIRT7, GEMIN5, UBC, SNRPE, HDAC2, HDAC5, CIAO1, GEMIN6, SNRPD2, SNRPD3, GEMIN4, SNRPD1, POLR1E, SNRPF, PPP4R2, BRF2, CLN3, LSM2, STXBP2, WRAP53 (tumor) | DDX20, SIRT7, GEMIN5, UBC, SNRPE, HDAC2, MYC, STXBP3, NCOR2, GEMIN6, DHX9, SNRPD3, GEMIN4, FBL, PHB2, POLR1E, SNRPF, SNUPN, LSM2, GAR1, STXBP2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DDX20, SIRT7, GEMIN5, UBC, SMN1, NCOR1, HDAC2, STXBP3, HDAC5, GSK3B, MED19, DHX9, SIN3A, GEMIN4, PNKP, GIGYF2, SNUPN, PPP4R2, BRF2, CLN3, ETV3 (tumor) | DDX20, SIRT7, GEMIN5, UBC, NCOR1, HDAC2, STXBP3, HDAC5, PTP4A3, MED29, DHX9, SNRPD3, SIN3A, GEMIN4, POLR1E, PNKP, GIGYF2, PPP4R2, CLN3, STXBP2, ETV3 (normal) |
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| KICH (tumor) | KICH (normal) |
| DDX20, SMN1, NCOR1, TCF3, MYC, CIAO1, MED19, MED29, SIN3A, GEMIN4, SNRPD1, FBL, SNRPF, PNKP, GIGYF2, PPP4R2, BRF2, CLN3, SNRPG, STXBP2, WRAP53 (tumor) | DDX20, GEMIN5, SUMO2, NCOR1, HDAC2, RNPS1, HDAC5, CIAO1, NCOR2, GEMIN6, SNRPD2, MED29, DHX9, PRKAB1, GEMIN4, PNKP, BRF2, LSM2, SNRPG, ETV3, WRAP53 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DDX20, UBC, SMN1, HDAC2, RNPS1, CIAO1, GSK3B, GEMIN6, SNRPD2, MED29, SNRPD3, SIN3A, SNRPB, PRKAB1, FBL, PHB2, PNKP, PPP4R2, CLN3, STXBP2, WRAP53 (tumor) | DDX20, SIRT7, NR0B2, HDAC2, TCF3, RNPS1, MYC, STXBP3, SNRPD2, MED29, DHX9, SIN3A, SNRPB, PRKAB1, PHB2, PNKP, SNUPN, BRF2, CLN3, STXBP2, ETV3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DDX20, GEMIN5, UBC, SUMO2, RNPS1, GSK3B, MED19, GEMIN6, SNRPD2, SNRPD3, SNRPB, PRKAB1, GEMIN4, SNRPD1, FBL, SNRPF, PNKP, PPP4R2, CLN3, LSM2, WRAP53 (tumor) | DDX20, GEMIN5, UBC, NCOR1, HDAC2, RNPS1, COPS5, STXBP3, HDAC5, GSK3B, SNRPD2, DHX9, SIN3A, SNRPB, GEMIN4, PHB2, GIGYF2, PPP4R2, CLN3, STXBP2, ETV3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DDX20, GEMIN5, SMN1, NR0B2, TCF3, STXBP3, GSK3B, NCOR2, GEMIN6, SNRPD2, DHX9, SIN3A, FBL, PHB2, SNRPF, PNKP, GIGYF2, SNUPN, PPP4R2, LSM2, ETV3 (tumor) | DDX20, GEMIN5, UBC, SMN1, NCOR1, NR0B2, HDAC2, TCF3, RNPS1, MYC, STXBP3, GSK3B, PTP4A3, DHX9, SIN3A, PHB2, PNKP, GIGYF2, PPP4R2, CLN3, ETV3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DDX20, SNRPE, SUMO2, HDAC2, COPS5, STXBP3, HDAC5, CIAO1, MED19, NCOR2, GEMIN6, SNRPD2, SNRPD1, FBL, PHB2, POLR1E, SNRPF, BRF2, LSM2, SNRPG, WRAP53 (tumor) | DDX20, SIRT7, GEMIN5, SNRPE, SUMO2, NR0B2, HDAC2, STXBP3, NCOR2, GEMIN6, SNRPD2, DHX9, PRKAB1, SNRPD1, FBL, POLR1E, PNKP, PPP4R2, CLN3, LSM2, STXBP2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DDX20, SNRPE, SUMO2, HDAC2, TCF3, COPS5, STXBP3, HDAC5, CIAO1, MED19, NCOR2, GEMIN6, SNRPD2, SNRPD3, SNRPD1, SNRPF, SNUPN, BRF2, CLN3, LSM2, SNRPG (tumor) | DDX20, SIRT7, GEMIN5, UBC, SNRPE, HDAC2, STXBP3, CIAO1, MED19, NCOR2, GEMIN6, PTP4A3, SNRPD2, DHX9, GEMIN4, SNRPD1, PHB2, PPP4R2, LSM2, STXBP2, WRAP53 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DDX20, SIRT7, GEMIN5, SMN1, TCF3, RNPS1, STXBP3, NCOR2, GEMIN6, MED29, SIN3A, PRKAB1, FBL, PNKP, PPP4R2, BRF2, CLN3, GAR1, STXBP2, ETV3, WRAP53 (tumor) | DDX20, GEMIN5, UBC, NCOR1, STXBP3, GSK3B, MED19, SNRPD2, DHX9, SNRPD3, SIN3A, SNRPB, PHB2, PNKP, GIGYF2, SNUPN, PPP4R2, CLN3, SNRPG, STXBP2, ETV3 (normal) |
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| STAD (tumor) | STAD (normal) |
| DDX20, SIRT7, GEMIN5, SNRPE, NR0B2, STXBP3, MED19, PTP4A3, MED29, DHX9, SIN3A, SNRPB, FBL, POLR1E, PNKP, SNUPN, BRF2, CLN3, STXBP2, ETV3, WRAP53 (tumor) | DDX20, SIRT7, GEMIN5, UBC, SNRPE, HDAC2, MYC, STXBP3, CIAO1, DHX9, SIN3A, GEMIN4, SNRPD1, FBL, POLR1E, SNRPF, PPP4R2, SNRPG, GAR1, STXBP2, WRAP53 (normal) |
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| THCA (tumor) | THCA (normal) |
| DDX20, SIRT7, GEMIN5, UBC, SUMO2, NCOR1, RNPS1, HDAC5, GSK3B, PTP4A3, SNRPD2, DHX9, SIN3A, SNRPB, PNKP, GIGYF2, PPP4R2, CLN3, LSM2, STXBP2, ETV3 (tumor) | DDX20, GEMIN5, UBC, SNRPE, NCOR1, RNPS1, STXBP3, HDAC5, SNRPD2, DHX9, SIN3A, SNRPB, SNRPD1, FBL, PNKP, GIGYF2, PPP4R2, CLN3, LSM2, STXBP2, ETV3 (normal) |
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| TissGeneProg for DDX20 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DDX20 |
| TissGeneDrug for DDX20 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DDX20 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0026847 | Spinal Muscular Atrophy | 3 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 2 | GAD |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree,GAD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0022665 | Kidney Neoplasm | 1 | GAD |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0085084 | Motor Neuron Disease | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0235025 | Peripheral motor neuropathy | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
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