 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for TREX2 |
 Gene summary |
| Basic gene information | Gene symbol | TREX2 |
| Gene name | three prime repair exonuclease 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: Xq28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_080701.3, NM_080699.2,NM_080700.2, | |
| Description | 3'-5' exonuclease TREX2 long form | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300370 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183479 | ||
| HPRD : 02299 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TREX2 | |
| BioGPS: 11219 | ||
| Pathway | NCI Pathway Interaction Database: TREX2 | |
| KEGG: TREX2 | ||
| REACTOME: TREX2 | ||
| Pathway Commons: TREX2 | ||
| Context | iHOP: TREX2 | |
| ligand binding site mutation search in PubMed: TREX2 | ||
| UCL Cancer Institute: TREX2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of TREX2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000738 | DNA catabolic process, exonucleolytic | 11279105 | GO:0006259 | DNA metabolic process | 11279105 | GO:0000738 | DNA catabolic process, exonucleolytic | 11279105 | GO:0006259 | DNA metabolic process | 11279105 |
| Top |
| TissGeneExp for TREX2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 1.262187629 | -0.371224871 | 1.6334125 | 6.29E-09 | 1.94E-08 |
| Top |
| TissGene-miRNA for TREX2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for TREX2 |
| TissGeneSNV for TREX2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L234M | KIRP | 1 |
| p.R156H | UCEC | 1 |
| p.D272N | BLCA | 1 |
| p.D123Y | DLBC | 1 |
| p.L74I | STAD | 1 |
| p.R99W | LGG | 1 |
| p.A28T | HNSC | 1 |
| p.S185N | UCS | 1 |
| p.C30R | UCEC | 1 |
| p.R24H | BLCA | 1 |
| p.R37H | READ | 1 |
| p.R37P | LIHC | 1 |
| p.V56I | UCEC | 1 |
| p.E191K | HNSC | 1 |
| p.T61M | PAAD | 1 |
| p.R12H | PRAD | 1 |
| p.V8I | STAD | 1 |
| p.R156L | BRCA | 1 |
| p.D89N | CESC | 1 |
| p.P9L | SKCM | 1 |
| p.S81N | UCEC | 1 |
| p.G5E | UCS | 1 |
| p.R37L | ACC | 1 |
| p.R207L | LUAD | 1 |
| p.V97M | GBM | 1 |
| p.D230N | BLCA | 1 |
| p.R24S | PRAD | 1 |
| p.L30V | LUAD | 1 |
| p.T104M | PAAD | 1 |
| p.R37H | LIHC | 1 |
| p.R165L | LUAD | 1 |
| p.P9S | SKCM | 1 |
| p.R137P | LUAD | 1 |
| p.R87* | UCEC | 1 |
| p.R165W | LUAD | 1 |
| p.E235A | DLBC | 1 |
| p.V97M | UCEC | 1 |
| p.R37C | STAD | 1 |
| p.R79C | STAD | 1 |
| Top |
| TissGeneCNV for TREX2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for TREX2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | X99270 | TREX2-NRXN1 | chrX:152730496 | chr2:51083187 |
| Top |
| TissGeneNet for TREX2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| TREX2, POLD1, ATF4 (tumor) | TREX2, POLD1, ATF4 (normal) |
 |  |
| Top |
| TissGeneProg for TREX2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for TREX2 |
| TissGeneDrug for TREX2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for TREX2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree,GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |