TissGeneSummary for BIRC8 |
Gene summary |
Basic gene information | Gene symbol | BIRC8 |
Gene name | baculoviral IAP repeat containing 8 | |
Synonyms | ILP-2|ILP2|hILP2 | |
Cytomap | UCSC genome browser: - | |
Type of gene | protein-coding | |
RefGenes | NM_033341.4, | |
Description | IAP-like protein 2baculoviral IAP repeat-containing 8baculoviral IAP repeat-containing protein 8inhibitor of apoptosis-like protein 2testis-specific inhibitor of apoptosis | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000163098 | ||
HPRD : 12525 | ||
Vega : OTTHUMG00000182919 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BIRC8 | |
BioGPS: 112401 | ||
Pathway | NCI Pathway Interaction Database: BIRC8 | |
KEGG: BIRC8 | ||
REACTOME: BIRC8 | ||
Pathway Commons: BIRC8 | ||
Context | iHOP: BIRC8 | |
ligand binding site mutation search in PubMed: BIRC8 | ||
UCL Cancer Institute: BIRC8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of BIRC8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for BIRC8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for BIRC8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for BIRC8 |
TissGeneSNV for BIRC8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P203S | SKCM | 2 |
p.K129N | UCEC | 1 |
p.R120Q | COAD | 1 |
p.R120Q | SKCM | 1 |
p.T98P | STAD | 1 |
p.V200G | UCEC | 1 |
p.L69M | BLCA | 1 |
p.A156T | DLBC | 1 |
p.L69Q | LIHC | 1 |
p.E147K | SKCM | 1 |
p.R120G | LUAD | 1 |
p.G122R | SKCM | 1 |
p.R120X | STAD | 1 |
p.A216E | LUAD | 1 |
p.R7W | SARC | 1 |
p.S17F | SKCM | 1 |
p.R120* | STAD | 1 |
p.G74R | LIHC | 1 |
p.R25K | LIHC | 1 |
p.D159N | SKCM | 1 |
p.E133D | UCEC | 1 |
p.S139C | BLCA | 1 |
p.T161I | BRCA | 1 |
p.G3S | SKCM | 1 |
p.V200I | SKCM | 1 |
p.R120Q | UCEC | 1 |
p.N79S | HNSC | 1 |
p.E185K | SKCM | 1 |
p.S169L | SKCM | 1 |
p.A198T | CESC | 1 |
p.Q137X | SKCM | 1 |
p.A198T | STAD | 1 |
p.Q171H | LUAD | 1 |
p.P64T | LUAD | 1 |
p.E147Q | BLCA | 1 |
p.P55S | SKCM | 1 |
p.G89E | SKCM | 1 |
p.E164X | PAAD | 1 |
p.E164* | PAAD | 1 |
p.E21Q | LUSC | 1 |
p.E134* | LUAD | 1 |
p.W49R | LUAD | 1 |
p.F229I | LUSC | 1 |
p.Q93K | CESC | 1 |
p.S169X | DLBC | 1 |
p.G89R | SKCM | 1 |
p.L115V | OV | 1 |
p.E88K | ESCA | 1 |
p.Q137* | SKCM | 1 |
p.S224G | STAD | 1 |
p.T95I | SKCM | 1 |
p.A6S | LUAD | 1 |
p.E117* | UCEC | 1 |
p.S106R | UCEC | 1 |
p.K52M | LUAD | 1 |
p.M222I | ESCA | 1 |
p.H206Y | LUAD | 1 |
p.G205X | STAD | 1 |
p.E186K | SKCM | 1 |
p.L149I | UCEC | 1 |
p.T2M | OV | 1 |
p.E186K | LUAD | 1 |
p.G205E | BRCA | 1 |
p.M1V | LUAD | 1 |
p.F123I | LIHC | 1 |
p.R232K | SKCM | 1 |
p.K67E | BRCA | 1 |
p.I197S | LIHC | 1 |
p.E72D | LUAD | 1 |
p.E88Q | BRCA | 1 |
p.F201V | STAD | 1 |
Top |
TissGeneCNV for BIRC8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for BIRC8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for BIRC8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for BIRC8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for BIRC8 |
TissGeneDrug for BIRC8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for BIRC8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |