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| TissGeneSummary for PTGDR2 |
 Gene summary |
| Basic gene information | Gene symbol | PTGDR2 |
| Gene name | prostaglandin D2 receptor 2 | |
| Synonyms | CD294|CRTH2|DL1R|DP2|GPR44 | |
| Cytomap | UCSC genome browser: 11q12-q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004778.2, | |
| Description | G protein-coupled receptor 44G-protein coupled receptor 44chemoattractant receptor homologous molecule expressed on T helper type 2 cellschemoattractant receptor-homologous molecule expressed on TH2 cellsputative G-protein coupled receptor 44 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604837 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183134 | ||
| HPRD : 16075 | ||
| Vega : OTTHUMG00000167796 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTGDR2 | |
| BioGPS: 11251 | ||
| Pathway | NCI Pathway Interaction Database: PTGDR2 | |
| KEGG: PTGDR2 | ||
| REACTOME: PTGDR2 | ||
| Pathway Commons: PTGDR2 | ||
| Context | iHOP: PTGDR2 | |
| ligand binding site mutation search in PubMed: PTGDR2 | ||
| UCL Cancer Institute: PTGDR2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomachThymus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTADTHYM | |
| Reference showing the relevant tissue of PTGDR2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006935 | chemotaxis | 11208866 | GO:0007186 | G-protein coupled receptor signaling pathway | 11208866 | GO:0019722 | calcium-mediated signaling | 11208866 | GO:0006935 | chemotaxis | 11208866 | GO:0007186 | G-protein coupled receptor signaling pathway | 11208866 | GO:0019722 | calcium-mediated signaling | 11208866 |
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| TissGeneExp for PTGDR2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PTGDR2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PTGDR2 |
| TissGeneSNV for PTGDR2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V204A | COAD | 5 |
| p.A34T | COAD | 1 |
| p.S174L | UCEC | 1 |
| p.F103L | BLCA | 1 |
| p.A274T | TGCT | 1 |
| p.R129C | LUAD | 1 |
| p.V48A | UCEC | 1 |
| p.N200K | LGG | 1 |
| p.S43L | ESCA | 1 |
| p.S109P | PRAD | 1 |
| p.A117P | STAD | 1 |
| p.A35V | COAD | 1 |
| p.L312Q | ACC | 1 |
| p.L153P | STAD | 1 |
| p.L75M | SARC | 1 |
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| TissGeneCNV for PTGDR2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PTGDR2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PTGDR2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for PTGDR2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PTGDR2 |
| TissGeneDrug for PTGDR2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00605 | Sulindac | Antagonist | Small molecule | Approved |
| DB00328 | Indomethacin | Other/unknown | Small molecule | Approved|Investigational |
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| TissGeneDisease for PTGDR2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 12 | BeFree,GAD,LHGDN |
| umls:C0011615 | Dermatitis, Atopic | 3 | BeFree,LHGDN |
| umls:C0013595 | Eczema | 3 | BeFree,GAD |
| umls:C0027430 | Nasal Polyps | 3 | BeFree |
| umls:C0020523 | Immediate hypersensitivity | 2 | GAD |
| umls:C0085129 | Bronchial Hyperreactivity | 2 | BeFree,GAD |
| umls:C0149516 | Chronic sinusitis | 2 | BeFree |
| umls:C0340068 | Aspirin-sensitive asthma with nasal polyps | 2 | BeFree |
| umls:C3539909 | Allergic disposition | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0014457 | Eosinophilia | 1 | BeFree |
| umls:C0016470 | Food Allergy | 1 | GAD |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0018621 | Hay fever | 1 | GAD |
| umls:C0021053 | Immune System Diseases | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0032285 | Pneumonia | 1 | BeFree |
| umls:C0042109 | Urticaria | 1 | GAD |
| umls:C0151650 | Renal fibrosis | 1 | BeFree |
| umls:C0155877 | Allergic asthma | 1 | BeFree |
| umls:C0242994 | Hantavirus Infections | 1 | BeFree |
| umls:C0263338 | Chronic urticaria | 1 | BeFree |
| umls:C0699949 | airway disease | 1 | BeFree |
| umls:C1306759 | Eosinophilic disorder | 1 | BeFree |
| umls:C1319853 | Asthma, Aspirin-Induced | 1 | CTD_human |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
| umls:C1636667 | Disorder characterized by eosinophilia | 1 | BeFree |
| umls:C3495801 | Granulomatosis with polyangiitis | 1 | BeFree |
| umls:C3662483 | Allergic sensitization | 1 | BeFree |
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