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| TissGeneSummary for STX1B |
 Gene summary |
| Basic gene information | Gene symbol | STX1B |
| Gene name | syntaxin 1B | |
| Synonyms | STX1B1|STX1B2 | |
| Cytomap | UCSC genome browser: 16p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_052874.3, | |
| Description | FP17469syntaxin 1B1syntaxin 1B2syntaxin-1Bsyntaxin-1B1syntaxin-1B2 | |
| Modification date | 20141214 | |
| dbXrefs | MIM : 601485 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000099365 | ||
| HPRD : 18126 | ||
| Vega : OTTHUMG00000132391 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STX1B | |
| BioGPS: 112755 | ||
| Pathway | NCI Pathway Interaction Database: STX1B | |
| KEGG: STX1B | ||
| REACTOME: STX1B | ||
| Pathway Commons: STX1B | ||
| Context | iHOP: STX1B | |
| ligand binding site mutation search in PubMed: STX1B | ||
| UCL Cancer Institute: STX1B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of STX1B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for STX1B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.220138321 | 1.318798847 | -1.098660526 | 1.26E-14 | 6.40E-14 |
| KIRC | 0.723413687 | -0.396323813 | 1.1197375 | 1.50E-10 | 5.20E-10 |
| THCA | 0.491037251 | -0.889108512 | 1.380145763 | 2.87E-11 | 2.06E-10 |
| KICH | -2.421677258 | -0.408557258 | -2.01312 | 1.81E-11 | 1.63E-10 |
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| TissGene-miRNA for STX1B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-31-5p | MIMAT0000089 | 0.048 | -0.27 | 60 |
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| TissGeneMut for STX1B |
| TissGeneSNV for STX1B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E128D | LUAD | 1 |
| p.H27N | LUSC | 1 |
| p.A63T | STAD | 1 |
| p.R25W | SKCM | 1 |
| p.I202M | ESCA | 1 |
| p.N86T | STAD | 1 |
| p.E162K | BLCA | 1 |
| p.S239Y | COAD | 1 |
| p.Y133N | LIHC | 1 |
| p.E233K | READ | 1 |
| p.R231H | ACC | 1 |
| p.S207G | UCEC | 1 |
| p.E17K | SKCM | 1 |
| p.R231H | UCEC | 1 |
| p.R143H | THYM | 1 |
| p.Q185R | STAD | 1 |
| p.D142N | SKCM | 1 |
| p.H238N | ESCA | 1 |
| p.E38* | HNSC | 1 |
| p.A11V | ESCA | 1 |
| p.V53L | LUAD | 1 |
| p.E169Q | LUSC | 1 |
| p.D183E | UCEC | 1 |
| p.E237K | SKCM | 1 |
| p.V243M | STAD | 1 |
| p.R209H | UCEC | 1 |
| p.F28L | STAD | 1 |
| p.E205D | READ | 1 |
| p.T155I | UCEC | 1 |
| p.E200K | SKCM | 1 |
| p.S90C | THCA | 1 |
| p.V23M | LUAD | 1 |
| p.F32L | UCEC | 1 |
| p.S90F | SKCM | 1 |
| p.Q276* | SKCM | 1 |
| p.N106K | CESC | 1 |
| p.D166N | BLCA | 1 |
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| TissGeneCNV for STX1B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for STX1B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF954561 | STX1B-GRIN1 | chr16:31002057 | chr9:140040214 |
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| TissGeneNet for STX1B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| COAD (tumor) | COAD (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| KICH (tumor) | KICH (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| STAD (tumor) | STAD (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| THCA (tumor) | THCA (normal) |
| STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (tumor) | STX1B, STXBP1, VAMP8, VAMP2, VAPB, UNC13B, VAMP1, SNAP23 (normal) |
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| TissGeneProg for STX1B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for STX1B |
| TissGeneDrug for STX1B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for STX1B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009952 | Febrile Convulsions | 1 | BeFree,CTD_human |
| umls:C0014544 | Epilepsy | 1 | BeFree,CTD_human |
| umls:C0030567 | Parkinson Disease | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C4015395 | GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 9 | 1 | UNIPROT |
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