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| TissGeneSummary for CTRC |
 Gene summary |
| Basic gene information | Gene symbol | CTRC |
| Gene name | chymotrypsin C (caldecrin) | |
| Synonyms | CLCR|ELA4 | |
| Cytomap | UCSC genome browser: 1p36.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007272.2, | |
| Description | caldecrinchymotrypsin-Celastase 4elastase IVserum calcium decreasing factor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601405 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000162438 | ||
| HPRD : 03242 | ||
| Vega : OTTHUMG00000002255 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CTRC | |
| BioGPS: 11330 | ||
| Pathway | NCI Pathway Interaction Database: CTRC | |
| KEGG: CTRC | ||
| REACTOME: CTRC | ||
| Pathway Commons: CTRC | ||
| Context | iHOP: CTRC | |
| ligand binding site mutation search in PubMed: CTRC | ||
| UCL Cancer Institute: CTRC | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of CTRC | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CTRC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for CTRC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CTRC |
| TissGeneSNV for CTRC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Y258C | LUAD | 1 |
| p.R37W | STAD | 1 |
| p.P179L | SKCM | 1 |
| p.P150R | LUAD | 1 |
| p.A123V | PAAD | 1 |
| p.R241W | UCEC | 1 |
| p.G17E | UCEC | 1 |
| p.V208I | HNSC | 1 |
| p.Q178* | UCEC | 1 |
| p.A28T | COAD | 1 |
| p.N166K | LUAD | 1 |
| p.S46F | SKCM | 1 |
| p.N120S | COAD | 1 |
| p.C17Y | ESCA | 1 |
| p.W23L | LUAD | 1 |
| p.W160* | LUAD | 1 |
| p.V86L | THYM | 1 |
| p.R188K | DLBC | 1 |
| p.W55G | SKCM | 1 |
| p.G167D | SKCM | 1 |
| p.T245I | SKCM | 1 |
| p.R254W | DLBC | 1 |
| p.P150L | SKCM | 1 |
| p.L63F | BRCA | 1 |
| p.K126N | STAD | 1 |
| p.V86M | SARC | 1 |
| p.R188S | BLCA | 1 |
| p.P42S | SKCM | 1 |
| p.S15P | KIRP | 1 |
| p.G227D | SKCM | 1 |
| p.A184S | LUAD | 1 |
| p.E264X | LIHC | 1 |
| p.P36L | SKCM | 1 |
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| TissGeneCNV for CTRC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CTRC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI835315 | CTRC-GABBR1 | chr1:15769008 | chr6:873338 |
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| TissGeneNet for CTRC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (tumor) | CTRC, SERPINA3, NEDD8, SPINK1, PHKG1 (normal) |
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| TissGeneProg for CTRC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CTRC |
| TissGeneDrug for CTRC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CTRC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0149521 | Pancreatitis, Chronic | 16 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0030305 | Pancreatitis | 7 | BeFree,GAD,LHGDN |
| umls:C0238339 | Hereditary pancreatitis | 6 | BeFree,CLINVAR,UNIPROT |
| umls:C0376670 | Pancreatitis, Alcoholic | 2 | GAD |
| umls:C1842402 | TROPICAL CALCIFIC PANCREATITIS | 2 | BeFree,ORPHANET |
| umls:C0001339 | Acute pancreatitis | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0085762 | Alcohol abuse | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0341471 | Idiopathic chronic pancreatitis | 1 | BeFree |
| umls:C1969419 | PANCREATITIS, CHRONIC, SUSCEPTIBILITY TO | 0 | CLINVAR |
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