TissGeneSummary for OIP5 |
Gene summary |
Basic gene information | Gene symbol | OIP5 |
Gene name | Opa interacting protein 5 | |
Synonyms | 5730547N13Rik|CT86|LINT-25|MIS18B|MIS18beta|hMIS18beta | |
Cytomap | UCSC genome browser: 15q15.1 | |
Type of gene | protein-coding | |
RefGenes | NM_007280.1, | |
Description | LAP2alpha interactor-25MIS18 kinetochore protein homolog BOIP-5cancer/testis antigen 86opa-interacting protein 5protein Mis18-beta | |
Modification date | 20141207 | |
dbXrefs | MIM : 606020 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104147 | ||
HPRD : 09352 | ||
Vega : OTTHUMG00000130251 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OIP5 | |
BioGPS: 11339 | ||
Pathway | NCI Pathway Interaction Database: OIP5 | |
KEGG: OIP5 | ||
REACTOME: OIP5 | ||
Pathway Commons: OIP5 | ||
Context | iHOP: OIP5 | |
ligand binding site mutation search in PubMed: OIP5 | ||
UCL Cancer Institute: OIP5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OIP5 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OIP5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | 0.482152503 | -2.545889602 | 3.028042105 | 3.97E-06 | 9.76E-05 |
HNSC | 0.349901708 | -0.79773085 | 1.147632558 | 7.02E-09 | 8.97E-08 |
STAD | 0.653396911 | -1.385531214 | 2.038928125 | 4.59E-07 | 8.82E-06 |
KIRP | -2.558362464 | -4.064146839 | 1.505784375 | 1.57E-06 | 7.64E-06 |
LUSC | 0.796841152 | -3.024090221 | 3.820931373 | 2.20E-36 | 4.13E-34 |
LIHC | -1.000954339 | -3.452194339 | 2.45124 | 9.80E-15 | 2.83E-13 |
LUAD | -0.868008477 | -3.166660201 | 2.298651724 | 1.91E-18 | 2.78E-17 |
BRCA | -0.344597497 | -2.939506268 | 2.594908772 | 2.39E-47 | 1.28E-45 |
KIRC | -2.039744061 | -3.859617672 | 1.819873611 | 1.07E-23 | 1.14E-22 |
ESCA | 0.619688389 | -2.418975248 | 3.038663636 | 5.01E-05 | 0.002025862 |
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TissGene-miRNA for OIP5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-107 | MIMAT0000104 | 0.0012 | -0.41 | 60 |
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TissGeneMut for OIP5 |
TissGeneSNV for OIP5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S48L | BLCA | 2 |
p.E73D | BLCA | 1 |
p.E59K | BLCA | 1 |
p.T176A | BLCA | 1 |
p.A85V | UCEC | 1 |
p.W39* | UCEC | 1 |
p.G22V | KIRC | 1 |
p.V44M | PRAD | 1 |
p.D96N | SKCM | 1 |
p.S212L | HNSC | 1 |
p.C75* | THYM | 1 |
p.S107F | LUAD | 1 |
p.D186N | BLCA | 1 |
p.T206M | UCEC | 1 |
p.A13T | COAD | 1 |
p.R9G | BRCA | 1 |
p.S10* | BLCA | 1 |
p.S107C | UVM | 1 |
p.P143S | SKCM | 1 |
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TissGeneCNV for OIP5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OIP5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE080901 | PCNP-OIP5 | chr3:101307542 | chr15:41614146 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0AM-01A | OIP5-NUSAP1 | Out-of-frame | Chr15:41611856 | Chr15:41657600 |
TCGAfusionPortal | PRADA | BRCA | TCGA-JL-A3YX-01A | MYO5A-OIP5 | In-frame | Chr15:52689398 | Chr15:41611978 |
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TissGeneNet for OIP5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OIP5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OIP5 |
TissGeneDrug for OIP5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OIP5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |