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| TissGeneSummary for CHRNA2 |
 Gene summary |
| Basic gene information | Gene symbol | CHRNA2 |
| Gene name | cholinergic receptor, nicotinic, alpha 2 (neuronal) | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 8p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000742.3, NM_001282455.1, | |
| Description | acetylcholine receptor, nicotinic, alpha 2 (neuronal)cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)neuronal acetylcholine receptor subunit alpha-2 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 118502 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120903 | ||
| HPRD : 00332 | ||
| Vega : OTTHUMG00000102083 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHRNA2 | |
| BioGPS: 1135 | ||
| Pathway | NCI Pathway Interaction Database: CHRNA2 | |
| KEGG: CHRNA2 | ||
| REACTOME: CHRNA2 | ||
| Pathway Commons: CHRNA2 | ||
| Context | iHOP: CHRNA2 | |
| ligand binding site mutation search in PubMed: CHRNA2 | ||
| UCL Cancer Institute: CHRNA2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of CHRNA2 | ||
| Description by TissGene annotations | Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006812 | cation transport | 8906617 | GO:0007165 | signal transduction | 8906617 | GO:0098655 | cation transmembrane transport | 8906617 | GO:0006812 | cation transport | 8906617 | GO:0007165 | signal transduction | 8906617 | GO:0098655 | cation transmembrane transport | 8906617 |
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| TissGeneExp for CHRNA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.59974637 | 1.33775559 | -2.937501961 | 2.55E-29 | 9.90E-28 |
| BRCA | -1.264423409 | 0.069503784 | -1.333927193 | 1.04E-07 | 3.12E-07 |
| LUAD | -1.520983118 | 1.802156537 | -3.323139655 | 2.97E-38 | 2.00E-35 |
| PRAD | 9.295190357 | 7.460996126 | 1.834194231 | 3.07E-05 | 0.000148593 |
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| TissGene-miRNA for CHRNA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CHRNA2 |
| TissGeneSNV for CHRNA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E418V | STAD | 2 |
| p.R394C | PAAD | 1 |
| p.E483D | UCEC | 1 |
| p.R68W | COAD | 1 |
| p.R68L | PRAD | 1 |
| p.A453V | STAD | 1 |
| p.F513L | THCA | 1 |
| p.V473M | STAD | 1 |
| p.E414K | SKCM | 1 |
| p.A93T | PAAD | 1 |
| p.V344A | BLCA | 1 |
| p.E316D | UCEC | 1 |
| p.P523L | SKCM | 1 |
| p.D193N | UCEC | 1 |
| p.H428Y | SKCM | 1 |
| p.P326L | LUAD | 1 |
| p.G52E | SKCM | 1 |
| p.P523S | SKCM | 1 |
| p.V387M | PAAD | 1 |
| p.P449S | LUAD | 1 |
| p.V349M | LUAD | 1 |
| p.P253S | SKCM | 1 |
| p.R68Q | UCEC | 1 |
| p.S10C | STAD | 1 |
| p.G229S | SKCM | 1 |
| p.E491G | HNSC | 1 |
| p.A93T | COAD | 1 |
| p.V260I | STAD | 1 |
| p.P275S | SKCM | 1 |
| p.L519I | UCEC | 1 |
| p.T188P | SKCM | 1 |
| p.I270M | BLCA | 1 |
| p.L505F | BLCA | 1 |
| p.R31H | UCEC | 1 |
| p.S116N | READ | 1 |
| p.G238S | SKCM | 1 |
| p.L41F | MESO | 1 |
| p.T168M | HNSC | 1 |
| p.G26R | SKCM | 1 |
| p.P383R | BLCA | 1 |
| p.D292N | UCEC | 1 |
| p.R61W | OV | 1 |
| p.E388D | LUAD | 1 |
| p.G527E | SKCM | 1 |
| p.G518D | SKCM | 1 |
| p.C281S | KIRC | 1 |
| p.F127S | THCA | 1 |
| p.V255I | PRAD | 1 |
| p.S322T | LIHC | 1 |
| p.G202D | LUAD | 1 |
| p.D97N | SKCM | 1 |
| p.R355H | ESCA | 1 |
| p.G53S | SKCM | 1 |
| p.T237M | UCS | 1 |
| p.Y148H | ESCA | 1 |
| p.S81L | SKCM | 1 |
| p.R68Q | DLBC | 1 |
| p.Q195H | UCEC | 1 |
| p.R376Q | STAD | 1 |
| p.S10Y | LUAD | 1 |
| p.R382W | SKCM | 1 |
| p.R121C | STAD | 1 |
| p.S132F | SKCM | 1 |
| p.G458C | SARC | 1 |
| p.I85F | HNSC | 1 |
| p.R72H | CESC | 1 |
| p.S167F | SKCM | 1 |
| p.W173* | SKCM | 1 |
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| TissGeneCNV for CHRNA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CHRNA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA405532 | CHRNA2-CAPN3 | chr8:27336813 | chr15:42699095 |
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| TissGeneNet for CHRNA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| COAD (tumor) | COAD (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| KICH (tumor) | KICH (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| STAD (tumor) | STAD (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| THCA (tumor) | THCA (normal) |
| CHRNA2, CHRNB4, CHRNB2 (tumor) | CHRNA2, CHRNB4, CHRNB2 (normal) |
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| TissGeneProg for CHRNA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CHRNA2 |
| TissGeneDrug for CHRNA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00184 | Nicotine | Agonist | Small molecule | Approved |
| DB00411 | Carbachol | Agonist | Small molecule | Approved |
| DB00483 | Gallamine Triethiodide | Antagonist | Small molecule | Approved |
| DB00565 | Cisatracurium besylate | Inhibitor | Small molecule | Approved |
| DB00657 | Mecamylamine | Inhibitor | Small molecule | Approved |
| DB00728 | Rocuronium | Antagonist | Small molecule | Approved |
| DB00732 | Atracurium besylate | Inhibitor | Small molecule | Approved |
| DB00810 | Biperiden | Antagonist | Small molecule | Approved |
| DB01135 | Doxacurium chloride | Antagonist | Small molecule | Approved |
| DB01199 | Tubocurarine | Antagonist | Small molecule | Approved |
| DB01226 | Mivacurium | Antagonist | Small molecule | Approved |
| DB01245 | Decamethonium | Partial agonist | Small molecule | Approved |
| DB01336 | Metocurine | Antagonist | Small molecule | Approved |
| DB01337 | Pancuronium | Antagonist | Small molecule | Approved |
| DB01338 | Pipecuronium | Antagonist | Small molecule | Approved |
| DB01339 | Vecuronium | Antagonist | Small molecule | Approved |
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| TissGeneDisease for CHRNA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C3696898 | Autosomal Dominant Nocturnal Frontal Lobe Epilepsy | 8 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 6 | GAD |
| umls:C0014544 | Epilepsy | 4 | BeFree,GAD |
| umls:C0085541 | Epilepsy, Frontal Lobe | 4 | BeFree,GAD,LHGDN |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0006012 | Borderline Personality Disorder | 1 | BeFree |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0014547 | Epilepsies, Partial | 1 | BeFree |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree,GAD |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0038580 | Substance Dependence | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | GAD |
| umls:C0233523 | Antisocial behavior | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | GAD |
| umls:C0497406 | Overweight | 1 | BeFree,GAD |
| umls:C0853193 | Bipolar I disorder | 1 | BeFree |
| umls:C0948750 | Salivary gland carcinoma | 1 | BeFree |
| umls:C1510472 | Drug Dependence | 1 | BeFree |
| umls:C1835905 | Epilepsy, Nocturnal Frontal Lobe, Type 4 | 1 | CLINVAR,CTD_human,UNIPROT |
| umls:C2911647 | Weight Gain Adverse Event | 1 | GAD |
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