TissGeneSummary for SIGLEC11 |
Gene summary |
Basic gene information | Gene symbol | SIGLEC11 |
Gene name | sialic acid binding Ig-like lectin 11 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001135163.1, NM_052884.2, | |
Description | sialic acid-binding Ig-like lectin 11siglec-11 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607157 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161640 | ||
HPRD : 06196 | ||
Vega : OTTHUMG00000157077 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SIGLEC11 | |
BioGPS: 114132 | ||
Pathway | NCI Pathway Interaction Database: SIGLEC11 | |
KEGG: SIGLEC11 | ||
REACTOME: SIGLEC11 | ||
Pathway Commons: SIGLEC11 | ||
Context | iHOP: SIGLEC11 | |
ligand binding site mutation search in PubMed: SIGLEC11 | ||
UCL Cancer Institute: SIGLEC11 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Ovary | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OV | |
Reference showing the relevant tissue of SIGLEC11 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SIGLEC11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.034754656 | -0.965162551 | -1.069592105 | 2.25E-10 | 8.63E-10 |
COAD | -1.679746289 | 0.009553711 | -1.6893 | 1.12E-07 | 7.79E-07 |
LUAD | -0.588103053 | 2.372521085 | -2.960624138 | 2.15E-18 | 3.07E-17 |
THCA | -1.590777776 | -0.121091335 | -1.469686441 | 2.03E-13 | 2.03E-12 |
LIHC | -0.850957674 | 1.784796326 | -2.635754 | 3.61E-16 | 1.36E-14 |
KICH | -2.101735674 | 0.583172326 | -2.684908 | 1.19E-11 | 1.12E-10 |
LUSC | -1.492082262 | 2.48934911 | -3.981431373 | 3.80E-27 | 1.11E-25 |
ESCA | -2.073511674 | 2.440706508 | -4.514218182 | 0.00201 | 0.02291736 |
BLCA | -2.131648516 | -1.062748516 | -1.0689 | 0.00343 | 0.019917285 |
STAD | -1.287449174 | 0.245857076 | -1.53330625 | 0.00191 | 0.008820513 |
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TissGene-miRNA for SIGLEC11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SIGLEC11 |
TissGeneSNV for SIGLEC11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G407E | SKCM | 2 |
p.E504K | SKCM | 2 |
p.P380R | CESC | 2 |
p.G76R | SKCM | 2 |
p.G374R | CESC | 2 |
p.G407R | SKCM | 2 |
p.E431K | SKCM | 2 |
p.S145N | CESC | 2 |
p.V453M | SKCM | 1 |
p.P697S | SKCM | 1 |
p.G501D | BLCA | 1 |
p.P456L | SKCM | 1 |
p.W655* | SKCM | 1 |
p.Q364K | THYM | 1 |
p.V178G | BRCA | 1 |
p.G376S | SKCM | 1 |
p.G628C | UCEC | 1 |
p.E422D | LUSC | 1 |
p.V581I | SKCM | 1 |
p.W559X | SKCM | 1 |
p.A154T | UCEC | 1 |
p.W406G | SKCM | 1 |
p.L442V | LUAD | 1 |
p.E638K | SKCM | 1 |
p.A147V | LUAD | 1 |
p.Q445K | LUAD | 1 |
p.S386I | SARC | 1 |
p.C186X | LIHC | 1 |
p.V485I | SKCM | 1 |
p.G566R | SKCM | 1 |
p.G560C | BLCA | 1 |
p.W406G | HNSC | 1 |
p.P397S | SKCM | 1 |
p.S308L | SKCM | 1 |
p.G496E | SKCM | 1 |
p.V447A | LGG | 1 |
p.R388S | LUSC | 1 |
p.V447I | COAD | 1 |
p.R339G | SKCM | 1 |
p.E371D | READ | 1 |
p.L518P | PCPG | 1 |
p.G376C | GBM | 1 |
p.P80L | SKCM | 1 |
p.P380R | HNSC | 1 |
p.D61N | SKCM | 1 |
p.P462L | KIRC | 1 |
p.L340P | TGCT | 1 |
p.G560D | SKCM | 1 |
p.A121V | LGG | 1 |
p.G470R | SKCM | 1 |
p.V581I | PRAD | 1 |
p.N29D | CESC | 1 |
p.E495D | GBM | 1 |
p.S79N | LIHC | 1 |
p.E371G | LUSC | 1 |
p.R132W | READ | 1 |
p.P80T | SKCM | 1 |
p.D108N | SKCM | 1 |
p.V581I | LGG | 1 |
p.P456S | STAD | 1 |
p.W406G | MESO | 1 |
p.G464D | SKCM | 1 |
p.R335G | CESC | 1 |
p.G83V | STAD | 1 |
p.P80R | OV | 1 |
p.P625Q | STAD | 1 |
p.R592C | STAD | 1 |
p.Q541H | BLCA | 1 |
p.S416L | HNSC | 1 |
p.E641V | LIHC | 1 |
p.V473I | COAD | 1 |
p.S509L | COAD | 1 |
p.W487* | SKCM | 1 |
p.A147V | UCEC | 1 |
p.G170R | COAD | 1 |
p.A438S | SKCM | 1 |
p.R531C | KIRP | 1 |
p.I586M | ESCA | 1 |
p.S66F | SKCM | 1 |
p.T506N | LUAD | 1 |
p.I51V | ESCA | 1 |
p.P380R | LUAD | 1 |
p.E371V | SKCM | 1 |
p.E542K | SKCM | 1 |
p.G511A | LUAD | 1 |
p.E356D | COAD | 1 |
p.R653K | HNSC | 1 |
p.R77W | LGG | 1 |
p.S481P | READ | 1 |
p.E337K | SKCM | 1 |
p.G651S | SKCM | 1 |
p.E431* | UCEC | 1 |
p.G374E | BLCA | 1 |
p.W406G | CESC | 1 |
p.A121T | LGG | 1 |
p.S465F | SKCM | 1 |
p.P169L | SKCM | 1 |
p.T316P | KIRP | 1 |
p.A482T | LGG | 1 |
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TissGeneCNV for SIGLEC11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SIGLEC11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SIGLEC11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SIGLEC11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SIGLEC11 |
TissGeneDrug for SIGLEC11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SIGLEC11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0267112 | Acute gastric mucosal erosion | 1 | BeFree |
umls:C2243088 | Idiopathic erosive/hemorrhagic gastritis | 1 | BeFree |