TissGeneSummary for PGLYRP2 |
Gene summary |
Basic gene information | Gene symbol | PGLYRP2 |
Gene name | peptidoglycan recognition protein 2 | |
Synonyms | HMFT0141|PGLYRPL|PGRP-L|PGRPL|TAGL-like|tagL|tagL-alpha|tagl-beta | |
Cytomap | UCSC genome browser: 19p13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_052890.3, | |
Description | N-acetylmuramoyl-L-alanine amidasepeptidoglycan recognition protein Lpeptidoglycan recognition protein long | |
Modification date | 20141207 | |
dbXrefs | MIM : 608199 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161031 | ||
HPRD : 10495 | ||
Vega : OTTHUMG00000150690 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PGLYRP2 | |
BioGPS: 114770 | ||
Pathway | NCI Pathway Interaction Database: PGLYRP2 | |
KEGG: PGLYRP2 | ||
REACTOME: PGLYRP2 | ||
Pathway Commons: PGLYRP2 | ||
Context | iHOP: PGLYRP2 | |
ligand binding site mutation search in PubMed: PGLYRP2 | ||
UCL Cancer Institute: PGLYRP2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of PGLYRP2 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0002221 | pattern recognition receptor signaling pathway | 11461926 | GO:0016045 | detection of bacterium | 11461926 | GO:0050830 | defense response to Gram-positive bacterium | 11461926 | GO:0002221 | pattern recognition receptor signaling pathway | 11461926 | GO:0016045 | detection of bacterium | 11461926 | GO:0050830 | defense response to Gram-positive bacterium | 11461926 |
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TissGeneExp for PGLYRP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 8.767198771 | 11.91302677 | -3.145828 | 1.51E-09 | 1.59E-08 |
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TissGene-miRNA for PGLYRP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PGLYRP2 |
TissGeneSNV for PGLYRP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P156S | SKCM | 2 |
p.L282F | SKCM | 2 |
p.H464Y | DLBC | 2 |
p.R394Q | COAD | 2 |
p.R396H | SKCM | 2 |
p.E107D | READ | 1 |
p.R315L | KIRP | 1 |
p.G521C | HNSC | 1 |
p.G443E | BLCA | 1 |
p.R320W | BRCA | 1 |
p.G195D | SKCM | 1 |
p.P294S | LGG | 1 |
p.S56* | LUAD | 1 |
p.G395D | PRAD | 1 |
p.R99Q | COAD | 1 |
p.R430L | LGG | 1 |
p.P571L | KICH | 1 |
p.P263L | GBM | 1 |
p.F376L | CESC | 1 |
p.F601C | UCEC | 1 |
p.S117T | HNSC | 1 |
p.D157Y | PRAD | 1 |
p.A130T | LUSC | 1 |
p.R500H | STAD | 1 |
p.T423M | KIRP | 1 |
p.L296F | SKCM | 1 |
p.H411Q | ESCA | 1 |
p.P567Q | OV | 1 |
p.R424C | UCEC | 1 |
p.P571T | LUAD | 1 |
p.K559R | SKCM | 1 |
p.P543L | LGG | 1 |
p.T259M | PAAD | 1 |
p.D250N | SKCM | 1 |
p.A167V | SKCM | 1 |
p.R319Q | STAD | 1 |
p.R135H | HNSC | 1 |
p.S475F | SKCM | 1 |
p.P178Q | PRAD | 1 |
p.A391V | STAD | 1 |
p.R319G | SKCM | 1 |
p.G279E | LUAD | 1 |
p.P531L | SKCM | 1 |
p.A2T | SKCM | 1 |
p.L232I | UCEC | 1 |
p.P292L | KIRC | 1 |
p.Q238* | LUAD | 1 |
p.R560S | LUAD | 1 |
p.E246K | HNSC | 1 |
p.V308M | LUAD | 1 |
p.F376S | LUAD | 1 |
p.P156S | READ | 1 |
p.E96K | SKCM | 1 |
p.A160D | READ | 1 |
p.G131V | COAD | 1 |
p.P83S | SKCM | 1 |
p.Y458H | PAAD | 1 |
p.S87N | COAD | 1 |
p.L9I | COAD | 1 |
p.N77I | KIRP | 1 |
p.A507V | STAD | 1 |
p.G405E | SKCM | 1 |
p.G234C | UCEC | 1 |
p.R99Q | BRCA | 1 |
p.S328L | SKCM | 1 |
p.D28N | SKCM | 1 |
p.T46A | COAD | 1 |
p.W74* | CESC | 1 |
p.A481T | HNSC | 1 |
p.S210P | HNSC | 1 |
p.P123L | SKCM | 1 |
p.L125Q | KIRC | 1 |
p.D537N | SKCM | 1 |
p.T541N | LUSC | 1 |
p.M270K | COAD | 1 |
p.D115A | SKCM | 1 |
p.R135C | STAD | 1 |
p.N428S | PCPG | 1 |
p.S561F | BLCA | 1 |
p.V451E | LUAD | 1 |
p.E371K | SKCM | 1 |
p.D175N | SKCM | 1 |
p.R551C | SKCM | 1 |
p.V111L | OV | 1 |
p.G279V | LUAD | 1 |
p.E291K | SKCM | 1 |
p.L343P | ESCA | 1 |
p.D184Y | BLCA | 1 |
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TissGeneCNV for PGLYRP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PGLYRP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PGLYRP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PGLYRP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PGLYRP2 |
TissGeneDrug for PGLYRP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PGLYRP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004623 | Bacterial Infections | 1 | LHGDN |
umls:C0007137 | Squamous cell carcinoma | 1 | GAD |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0007786 | Brain Ischemia | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GAD |
umls:C0011334 | Dental caries | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | GAD |
umls:C0038454 | Cerebrovascular accident | 1 | GAD |
umls:C0333519 | Caries (morphologic abnormality) | 1 | BeFree |