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| TissGeneSummary for CIDEA |
 Gene summary |
| Basic gene information | Gene symbol | CIDEA |
| Gene name | cell death-inducing DFFA-like effector a | |
| Synonyms | CIDE-A | |
| Cytomap | UCSC genome browser: 18p11.21|18 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001279.3, NR_036468.1, | |
| Description | cell death activator CIDE-A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604440 | |
| HGNC : HGNC | ||
| HPRD : 08380 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CIDEA | |
| BioGPS: 1149 | ||
| Pathway | NCI Pathway Interaction Database: CIDEA | |
| KEGG: CIDEA | ||
| REACTOME: CIDEA | ||
| Pathway Commons: CIDEA | ||
| Context | iHOP: CIDEA | |
| ligand binding site mutation search in PubMed: CIDEA | ||
| UCL Cancer Institute: CIDEA | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSoft tissueSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASARCSKCM | |
| Reference showing the relevant tissue of CIDEA | ||
| Description by TissGene annotations | Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CIDEA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.941639161 | -0.812123906 | -1.129515254 | 1.62E-08 | 7.88E-08 |
| HNSC | 0.119771876 | 3.963713736 | -3.84394186 | 5.83E-15 | 4.23E-13 |
| STAD | -0.946450072 | 1.962178053 | -2.908628125 | 2.62E-06 | 3.81E-05 |
| BRCA | 1.165535564 | 6.756120652 | -5.590585088 | 7.23E-38 | 1.79E-36 |
| COAD | -1.207814976 | 0.421073486 | -1.628888462 | 0.00386 | 0.009534679 |
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| TissGene-miRNA for CIDEA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CIDEA |
| TissGeneSNV for CIDEA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D160N | SKCM | 1 |
| p.S60I | LUAD | 1 |
| p.Q56K | LUAD | 1 |
| p.G214S | SKCM | 1 |
| p.T164P | STAD | 1 |
| p.E88* | HNSC | 1 |
| p.F131Y | THCA | 1 |
| p.P110S | SKCM | 1 |
| p.F176L | BLCA | 1 |
| p.D129N | UCEC | 1 |
| p.G214D | SKCM | 1 |
| p.R48H | GBM | 1 |
| p.E88Q | BLCA | 1 |
| p.E153V | GBM | 1 |
| p.S156F | SKCM | 1 |
| p.T184M | ESCA | 1 |
| p.L174M | LIHC | 1 |
| p.V67I | UCEC | 1 |
| p.E153K | SKCM | 1 |
| p.V157M | ACC | 1 |
| p.N130S | UCEC | 1 |
| p.P150T | OV | 1 |
| p.D140N | SKCM | 1 |
| p.R24* | PAAD | 1 |
| p.R58* | UCEC | 1 |
| p.T82I | PAAD | 1 |
| p.A3V | SKCM | 1 |
| p.V101I | UCEC | 1 |
| p.E153K | LUAD | 1 |
| p.R24X | PAAD | 1 |
| p.R135G | STAD | 1 |
| p.G168V | COAD | 1 |
| p.D80G | STAD | 1 |
| p.S60I | HNSC | 1 |
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| TissGeneCNV for CIDEA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CIDEA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | MESO | TCGA-SC-A6LN-01A | ETV6-CIDEA | Out-of-Frame | chr12:11803091 | chr18:12274089 |
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| TissGeneNet for CIDEA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (tumor) | CIDEA, ZBTB16, NR1H2, CIDEB, UCP1 (normal) |
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| TissGeneProg for CIDEA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CIDEA |
| TissGeneDrug for CIDEA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CIDEA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 9 | BeFree,CTD_human,GAD |
| umls:C0524620 | Metabolic Syndrome X | 3 | BeFree,GAD |
| umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
| umls:C0006625 | Cachexia | 1 | LHGDN |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | CTD_human |
| umls:C0154251 | Lipid Metabolism Disorders | 1 | BeFree |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | BeFree |
| umls:C0340629 | Aortic aneurysm without mention of rupture NOS | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C1402315 | Vascular lesions | 1 | BeFree |
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