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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC26A9
check button Gene summary
Basic gene informationGene symbolSLC26A9
Gene namesolute carrier family 26 (anion exchanger), member 9
Synonyms-
CytomapUCSC genome browser: 1q32.1
Type of geneprotein-coding
RefGenesNM_052934.3,
NM_134325.2,NM_001142600.1,
Descriptionanion transporter/exchanger protein 9anion transporter/exchanger-9solute carrier family 26 member 9solute carrier family 26, member 9
Modification date20141207
dbXrefs MIM : 608481
HGNC : HGNC
Ensembl : ENSG00000174502
HPRD : 12242
Vega : OTTHUMG00000036001
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC26A9
BioGPS: 115019
PathwayNCI Pathway Interaction Database: SLC26A9
KEGG: SLC26A9
REACTOME: SLC26A9
Pathway Commons: SLC26A9
ContextiHOP: SLC26A9
ligand binding site mutation search in PubMed: SLC26A9
UCL Cancer Institute: SLC26A9
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)PancreasStomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAADSTAD
Reference showing the relevant tissue of SLC26A9
Description by TissGene annotationsHave significant anti-correlated miRNA
Fused withOncogene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006820anion transport11834742
GO:0006821chloride transport15800055
GO:0010628positive regulation of gene expression20658517
GO:0015701bicarbonate transport15800055
GO:1902476chloride transmembrane transport17673510
GO:0006820anion transport11834742
GO:0006821chloride transport15800055
GO:0010628positive regulation of gene expression20658517
GO:0015701bicarbonate transport15800055
GO:1902476chloride transmembrane transport17673510


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TissGeneExp for SLC26A9

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.3516082682.141819732-3.4934283.45E-059.86E-05
KIRP-0.0934973933.378171357-3.471668755.39E-094.35E-08
LUSC0.8379282815.116065535-4.2781372554.31E-183.96E-17
THCA0.0800218331.788142172-1.7081203391.57E-121.33E-11
HNSC1.2334696852.733492941-1.5000232560.005130.013839928
COAD-3.080144268-4.3671442681.2870.0008830.002565853
LUAD3.5790471115.067360904-1.4883137930.000120.000299399


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TissGene-miRNA for SLC26A9

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-96-5pMIMAT00000950.041-0.2760
UCShsa-miR-26a-5pMIMAT00000820.022-0.3156
UCShsa-miR-181d-5pMIMAT00028210.019-0.3156


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TissGeneMut for SLC26A9
TissGeneSNV for SLC26A9

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A552TSTAD2
p.P607SSKCM2
p.S472FSKCM2
p.K443NUCEC1
p.R317SESCA1
p.S324TLIHC1
p.G225RREAD1
p.G54EBLCA1
p.M369ISKCM1
p.S871FCOAD1
p.A164VUCEC1
p.V9MUCEC1
p.P606SLIHC1
p.P558LSKCM1
p.R500QSKCM1
p.P99SSKCM1
p.P325SSKCM1
p.N247YSKCM1
p.Y865HLIHC1
p.G118ELGG1
p.I204LSKCM1
p.S392CBLCA1
p.P428TUCEC1
p.T661SLUAD1
p.D332NSKCM1
p.M1IBRCA1
p.A737VREAD1
p.G54DBLCA1
p.Q448KSARC1
p.R29QHNSC1
p.A350VCESC1
p.G713ESKCM1
p.H121YSKCM1
p.Y534HSTAD1
p.T787PPCPG1
p.S218LSKCM1
p.R12KSKCM1
p.A211DHNSC1
p.E166DUCEC1
p.I237VBRCA1
p.A14TLUAD1
p.S16CBLCA1
p.P320SSKCM1
p.M577IBLCA1
p.Q600HUCEC1
p.A337TUCEC1
p.N376SSKCM1
p.V346IBRCA1
p.R281CREAD1
p.R576KHNSC1
p.A785TDLBC1
p.W772*SKCM1
p.P629SSKCM1
p.A259TUCEC1
p.A407TCOAD1
p.A643DSARC1
p.M588ISKCM1
p.A14TBLCA1
p.Y707HUCEC1
p.L98HSTAD1
p.H748RCOAD1
p.P874SSKCM1
p.P452LSKCM1
p.G402ESKCM1
p.H278QBRCA1
p.G841ESKCM1
p.G186SSKCM1
p.Q507ETHCA1
p.H784YSKCM1
p.R38CUCEC1
p.S764LSKCM1
p.L665FSKCM1
p.H250YACC1
p.G89SSKCM1
p.A210TCOAD1
p.E23KSKCM1
p.S877LSKCM1
p.I680MCESC1
p.M1IESCA1
p.R38HPAAD1
p.S236FSKCM1
p.S230CSKCM1
p.Q599EESCA1
p.V715IUCEC1
p.K565QSARC1
p.A181PHNSC1
p.M416ISKCM1
p.Y480HTHYM1
p.R769HSKCM1
p.R769HHNSC1
p.S324LCOAD1
p.K68EBLCA1
p.D362NLUAD1
p.V267ELIHC1
p.E792KUCEC1
p.R575WUCEC1
p.R769CSKCM1
p.D364HBRCA1
p.S324LUVM1
p.R38CHNSC1
p.H663NACC1
p.D844YSTAD1
p.T745ISKCM1
p.P452SSKCM1
p.R7LLUAD1
p.E806DSTAD1
p.S404CSKCM1
p.A733TREAD1
p.E201KBLCA1
p.A737VESCA1
p.A790TREAD1
p.L199FSKCM1
p.V550GCOAD1
p.D732NKIRP1
p.R38CLUAD1
p.D525NSTAD1
p.A390VREAD1
p.D22EOV1
p.E25QBRCA1


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TissGeneCNV for SLC26A9

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC26A9

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanBRCATCGA-E2-A1B0-01ANUCKS1-SLC26A9In-Framechr1:205719084chr1:205902212
TCGAfusionPortalPRADAPRADTCGA-HC-8265-01AELK4-SLC26A9CDS-5UTRChr1:205592804Chr1:205904966


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TissGeneNet for SLC26A9

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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COAD (tumor)COAD (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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HNSC (tumor)HNSC (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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KICH (tumor)KICH (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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KIRC (tumor)KIRC (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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KIRP (tumor)KIRP (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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LIHC (tumor)LIHC (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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LUAD (tumor)LUAD (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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LUSC (tumor)LUSC (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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PRAD (tumor)PRAD (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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STAD (tumor)STAD (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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THCA (tumor)THCA (normal)
SLC26A9, CFTR (tumor)SLC26A9, CFTR (normal)
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TissGeneProg for SLC26A9

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC26A9
TissGeneDrug for SLC26A9

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC26A9

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0024115Lung diseases2BeFree
umls:C0270246Meconium plug syndrome2BeFree
umls:C0546982Cystic fibrosis with meconium ileus2BeFree
umls:C2939175Meconium ileus2BeFree
umls:C0001883Airway Obstruction1BeFree
umls:C0004096Asthma1BeFree
umls:C0010674Cystic Fibrosis1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0019196Hepatitis C1GAD
umls:C0021843Intestinal Obstruction1CTD_human
umls:C0030286Pancreatic Diseases1BeFree
umls:C0333133Mucus cast1BeFree
umls:C0339985Idiopathic bronchiectasis1BeFree
umls:C0699949airway disease1BeFree
umls:C1859047CYSTIC FIBROSIS MODIFIER 11CTD_human