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| TissGeneSummary for SLC26A7 |
 Gene summary |
| Basic gene information | Gene symbol | SLC26A7 |
| Gene name | solute carrier family 26 (anion exchanger), member 7 | |
| Synonyms | SUT2 | |
| Cytomap | UCSC genome browser: 8q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001282356.1, NM_001282357.1,NM_052832.3,NM_134266.1, | |
| Description | anion exchange transportersolute carrier family 26, member 7sulfate anion transporter | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608479 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147606 | ||
| HPRD : 10533 | ||
| Vega : OTTHUMG00000164062 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC26A7 | |
| BioGPS: 115111 | ||
| Pathway | NCI Pathway Interaction Database: SLC26A7 | |
| KEGG: SLC26A7 | ||
| REACTOME: SLC26A7 | ||
| Pathway Commons: SLC26A7 | ||
| Context | iHOP: SLC26A7 | |
| ligand binding site mutation search in PubMed: SLC26A7 | ||
| UCL Cancer Institute: SLC26A7 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyProstateThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPRADTHCA | |
| Reference showing the relevant tissue of SLC26A7 | SLC26 chloride/base exchangers in the kidney in health and disease. Soleimani M, Xu J. Semin Nephrol. 2006 Sep;26(5):375-85. Review (pmid:17071331) go to article | |
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006820 | anion transport | 11834742 | GO:0006821 | chloride transport | 1183472 | GO:0008272 | sulfate transport | 1183472 | GO:0019532 | oxalate transport | 1183472 | GO:1902358 | sulfate transmembrane transport | 1183472 | GO:0006820 | anion transport | 11834742 | GO:0006821 | chloride transport | 1183472 | GO:0008272 | sulfate transport | 1183472 | GO:0019532 | oxalate transport | 1183472 | GO:1902358 | sulfate transmembrane transport | 1183472 |
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| TissGeneExp for SLC26A7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.953617556 | 6.027097721 | -6.980715278 | 1.47E-46 | 9.69E-45 |
| KIRP | -0.671013043 | 5.898761957 | -6.569775 | 1.79E-18 | 8.72E-17 |
| PRAD | -2.658069052 | -1.547863283 | -1.110205769 | 1.05E-06 | 7.42E-06 |
| BRCA | -1.648231738 | 0.024410368 | -1.672642105 | 4.23E-21 | 3.27E-20 |
| THCA | 6.033618366 | 9.582148875 | -3.548530508 | 1.02E-18 | 2.93E-17 |
| STAD | -2.622197418 | -1.351416168 | -1.27078125 | 0.0087 | 0.030910427 |
| COAD | -2.670507514 | -1.390745975 | -1.279761538 | 3.51E-05 | 0.000142152 |
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| TissGene-miRNA for SLC26A7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-223-3p | MIMAT0000280 | 0.0037 | -0.32 | 80 |
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| TissGeneMut for SLC26A7 |
| TissGeneSNV for SLC26A7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E626D | UCEC | 2 |
| p.M95I | SKCM | 2 |
| p.P86S | SKCM | 2 |
| p.E285X | COAD | 1 |
| p.E221Q | CESC | 1 |
| p.L537F | SKCM | 1 |
| p.P662S | HNSC | 1 |
| p.V134M | STAD | 1 |
| p.E229K | SKCM | 1 |
| p.D495N | READ | 1 |
| p.H98N | BLCA | 1 |
| p.D495V | LUAD | 1 |
| p.P628R | HNSC | 1 |
| p.V77L | LIHC | 1 |
| p.N622S | STAD | 1 |
| p.T188A | LUSC | 1 |
| p.S237N | CHOL | 1 |
| p.D340N | LUAD | 1 |
| p.A187S | LIHC | 1 |
| p.S138P | LUAD | 1 |
| p.A322S | LUAD | 1 |
| p.T580A | SKCM | 1 |
| p.F334I | COAD | 1 |
| p.D539N | SKCM | 1 |
| p.R227* | UCEC | 1 |
| p.V261L | LUAD | 1 |
| p.A331T | COAD | 1 |
| p.M494T | BLCA | 1 |
| p.G82R | SKCM | 1 |
| p.S506L | LUAD | 1 |
| p.E560K | STAD | 1 |
| p.P260L | SKCM | 1 |
| p.I215V | COAD | 1 |
| p.G208R | UCEC | 1 |
| p.T659K | LUAD | 1 |
| p.G599V | LUAD | 1 |
| p.Q535H | LUSC | 1 |
| p.M302I | SKCM | 1 |
| p.C533R | KIRC | 1 |
| p.I338F | COAD | 1 |
| p.L349P | UCEC | 1 |
| p.P300A | LUAD | 1 |
| p.D575Y | LUSC | 1 |
| p.I505T | KICH | 1 |
| p.V446A | STAD | 1 |
| p.G456A | BLCA | 1 |
| p.I267S | PAAD | 1 |
| p.S330C | BLCA | 1 |
| p.K491N | LUAD | 1 |
| p.K542E | ESCA | 1 |
| p.V656I | GBM | 1 |
| p.V433A | STAD | 1 |
| p.P361T | OV | 1 |
| p.K7I | UCEC | 1 |
| p.K481Q | UCEC | 1 |
| p.L135M | UCEC | 1 |
| p.G155E | STAD | 1 |
| p.P204L | SKCM | 1 |
| p.K252N | LUAD | 1 |
| p.T127N | HNSC | 1 |
| p.G136R | LUAD | 1 |
| p.S306C | LUAD | 1 |
| p.L198I | LGG | 1 |
| p.S588F | LUAD | 1 |
| p.M123R | OV | 1 |
| p.K518T | COAD | 1 |
| p.Q143* | LUSC | 1 |
| p.D262G | LIHC | 1 |
| p.C387* | LUAD | 1 |
| p.A67D | READ | 1 |
| p.M660T | HNSC | 1 |
| p.Q292R | UCEC | 1 |
| p.G211E | SKCM | 1 |
| p.G398V | UCEC | 1 |
| p.W438X | SKCM | 1 |
| p.A67T | DLBC | 1 |
| p.T184A | UCEC | 1 |
| p.Y520* | LUSC | 1 |
| p.P662Q | ESCA | 1 |
| p.K5N | LGG | 1 |
| p.A377S | UCEC | 1 |
| p.R144S | LUAD | 1 |
| p.S111L | ESCA | 1 |
| p.L427F | HNSC | 1 |
| p.G621* | LUAD | 1 |
| p.D603N | COAD | 1 |
| p.M526I | UCEC | 1 |
| p.G416R | SKCM | 1 |
| p.Q501R | UCEC | 1 |
| p.E626D | LGG | 1 |
| p.R425Q | UCEC | 1 |
| p.P120L | LUAD | 1 |
| p.E560K | SKCM | 1 |
| p.P566S | HNSC | 1 |
| p.S386F | LUSC | 1 |
| p.L657I | BRCA | 1 |
| p.S601G | UCEC | 1 |
| p.V226A | STAD | 1 |
| p.E592K | HNSC | 1 |
| p.K254T | LUSC | 1 |
| p.I294T | SKCM | 1 |
| p.F358V | STAD | 1 |
| p.P120S | SKCM | 1 |
| p.A91S | UCEC | 1 |
| p.R253S | SKCM | 1 |
| p.N534D | READ | 1 |
| p.Y320C | LUAD | 1 |
| p.S207Y | STAD | 1 |
| p.W27C | LUAD | 1 |
| p.M486I | READ | 1 |
| p.P19L | SARC | 1 |
| p.I436T | LUAD | 1 |
| p.L154F | LUAD | 1 |
| p.A312S | LUAD | 1 |
| p.G329* | LGG | 1 |
| p.Q500K | LUSC | 1 |
| p.F581I | LIHC | 1 |
| p.E176X | LIHC | 1 |
| p.G419* | HNSC | 1 |
| p.A161T | KIRP | 1 |
| p.A181E | LUAD | 1 |
| p.S72L | SKCM | 1 |
| p.S577G | PRAD | 1 |
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| TissGeneCNV for SLC26A7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC26A7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AU137042 | SLC26A7-TDRD3 | chr8:92337422 | chr13:61146439 | |
| Chimerdb3.0 | ChiTaRs | NA | AA992584 | NDUFS3-SLC26A7 | chr11:47606114 | chr8:92375701 | |
| Chimerdb3.0 | ChiTaRs | NA | BE172036 | LPHN3-SLC26A7 | chr4:62349923 | chr8:92408531 | |
| Chimerdb3.0 | ChiTaRs | NA | BF987124 | RAI14-SLC26A7 | chr5:34826518 | chr8:92295186 | |
| TCGAfusionPortal | PRADA | KIRC | TCGA-B0-5713-01A | LRIG1-SLC26A7 | CDS-5UTR | Chr3:66444464 | Chr8:92261767 |
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| TissGeneNet for SLC26A7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC26A7, HNF1A (tumor) | SLC26A7, HNF1A (normal) |
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| TissGeneProg for SLC26A7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC26A7 |
| TissGeneDrug for SLC26A7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC26A7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0949664 | Tauopathies | 3 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0020621 | Hypokalemia | 1 | LHGDN |
| umls:C0036341 | Schizophrenia | 1 | CTD_human |
| umls:C0037889 | Hereditary spherocytosis | 1 | BeFree |
| umls:C0220726 | Diastrophic dysplasia | 1 | BeFree |
| umls:C1704380 | Distal Renal Tubular Acidosis | 1 | BeFree |
| umls:C1971021 | Potassium depletion | 1 | BeFree |
| umls:C2674218 | SPHEROCYTOSIS, TYPE 1 (disorder) | 1 | BeFree |
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