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| TissGeneSummary for GBP4 |
 Gene summary |
| Basic gene information | Gene symbol | GBP4 |
| Gene name | guanylate binding protein 4 | |
| Synonyms | Mpa2 | |
| Cytomap | UCSC genome browser: 1p22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_052941.4, | |
| Description | GBP-4GTP-binding protein 4guanine nucleotide-binding protein 4guanylate-binding protein 4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612466 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000162654 | ||
| HPRD : 13570 | ||
| Vega : OTTHUMG00000010663 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GBP4 | |
| BioGPS: 115361 | ||
| Pathway | NCI Pathway Interaction Database: GBP4 | |
| KEGG: GBP4 | ||
| REACTOME: GBP4 | ||
| Pathway Commons: GBP4 | ||
| Context | iHOP: GBP4 | |
| ligand binding site mutation search in PubMed: GBP4 | ||
| UCL Cancer Institute: GBP4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCUCEC,UCS | |
| Reference showing the relevant tissue of GBP4 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GBP4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 1.845160952 | 0.708370674 | 1.136790278 | 1.21E-11 | 4.68E-11 |
| KIRP | -1.229384187 | 0.290781438 | -1.520165625 | 3.13E-08 | 2.17E-07 |
| LUAD | 0.407269908 | 1.935071632 | -1.527801724 | 2.27E-11 | 1.50E-10 |
| LUSC | -0.055460045 | 1.957259563 | -2.012719608 | 2.07E-14 | 1.17E-13 |
| STAD | 1.178112688 | 0.126662688 | 1.05145 | 0.000783 | 0.004386109 |
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| TissGene-miRNA for GBP4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GBP4 |
| TissGeneSNV for GBP4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K388T | BLCA | 1 |
| p.M353I | BLCA | 1 |
| p.L425P | BLCA | 1 |
| p.H566D | LUSC | 1 |
| p.D190E | LUAD | 1 |
| p.E526* | LUSC | 1 |
| p.E551G | COAD | 1 |
| p.Y450H | LUAD | 1 |
| p.R168M | SKCM | 1 |
| p.N39H | UCEC | 1 |
| p.R639H | UCEC | 1 |
| p.S350I | UCEC | 1 |
| p.S232L | BLCA | 1 |
| p.E298D | STAD | 1 |
| p.L166V | BRCA | 1 |
| p.D493N | BLCA | 1 |
| p.C421Y | PRAD | 1 |
| p.D369N | COAD | 1 |
| p.Y541N | COAD | 1 |
| p.T433I | LUSC | 1 |
| p.D118N | SARC | 1 |
| p.K91N | STAD | 1 |
| p.V620A | READ | 1 |
| p.M509I | LUAD | 1 |
| p.V370L | LUAD | 1 |
| p.S182R | LUAD | 1 |
| p.E179Q | LUSC | 1 |
| p.L636F | SKCM | 1 |
| p.H560Q | PRAD | 1 |
| p.E114K | BLCA | 1 |
| p.E473K | SKCM | 1 |
| p.S280L | BLCA | 1 |
| p.R376K | LUAD | 1 |
| p.D176H | BRCA | 1 |
| p.M353I | HNSC | 1 |
| p.R244* | UCEC | 1 |
| p.E201K | SKCM | 1 |
| p.L557I | ACC | 1 |
| p.P623T | LUAD | 1 |
| p.D493G | UCEC | 1 |
| p.R438T | BLCA | 1 |
| p.L61P | LUAD | 1 |
| p.A354S | BLCA | 1 |
| p.E603G | LUAD | 1 |
| p.A341V | PAAD | 1 |
| p.H431L | LUAD | 1 |
| p.G499R | LAML | 1 |
| p.A132V | SKCM | 1 |
| p.Q35H | LUAD | 1 |
| p.E162Q | CESC | 1 |
| p.A291V | READ | 1 |
| p.E595D | BRCA | 1 |
| p.E473K | UCEC | 1 |
| p.E551K | COAD | 1 |
| p.S442F | SKCM | 1 |
| p.Q343X | THYM | 1 |
| p.E572* | UCEC | 1 |
| p.A185V | THYM | 1 |
| p.E526K | LAML | 1 |
| p.K225R | STAD | 1 |
| p.M542I | COAD | 1 |
| p.R196W | UCEC | 1 |
| p.E114K | BRCA | 1 |
| p.K406T | LUAD | 1 |
| p.V142I | COAD | 1 |
| p.K121N | LAML | 1 |
| p.E572K | BRCA | 1 |
| p.P175H | LUAD | 1 |
| p.S481L | PAAD | 1 |
| p.E34K | SKCM | 1 |
| p.M70I | SKCM | 1 |
| p.Q412H | BLCA | 1 |
| p.P81R | HNSC | 1 |
| p.V146A | CESC | 1 |
| p.M618T | HNSC | 1 |
| p.Q343X | COAD | 1 |
| p.S232* | UCEC | 1 |
| p.L367P | OV | 1 |
| p.R507Q | UCEC | 1 |
| p.E473D | LUSC | 1 |
| p.R72C | UCEC | 1 |
| p.Q476H | UCEC | 1 |
| p.Q355K | BLCA | 1 |
| p.E589* | UCEC | 1 |
| p.S435I | LUAD | 1 |
| p.V53L | LUAD | 1 |
| p.A329V | LUAD | 1 |
| p.D176H | LUSC | 1 |
| p.G115D | SKCM | 1 |
| p.G637S | LUAD | 1 |
| p.L277I | COAD | 1 |
| p.A185V | UCEC | 1 |
| p.V443A | OV | 1 |
| p.T293S | LUAD | 1 |
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| TissGeneCNV for GBP4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GBP4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BC050625 | FTL-GBP4 | chr19:49468813 | chr1:89647456 | |
| Chimerdb3.0 | ChiTaRs | NA | BU166365 | FTL-GBP4 | chr19:49468813 | chr1:89657076 |
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| TissGeneNet for GBP4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for GBP4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GBP4 |
| TissGeneDrug for GBP4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GBP4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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