TissGeneSummary for CISH |
Gene summary |
Basic gene information | Gene symbol | CISH |
Gene name | cytokine inducible SH2-containing protein | |
Synonyms | BACTS2|CIS|CIS-1|G18|SOCS | |
Cytomap | UCSC genome browser: 3p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_013324.5, NM_145071.2, | |
Description | cytokine-inducible SH2-containing proteincytokine-inducible inhibitor of signaling type 1Bsuppressor of cytokine signaling | |
Modification date | 20141207 | |
dbXrefs | MIM : 602441 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114737 | ||
HPRD : 03897 | ||
Vega : OTTHUMG00000156853 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CISH | |
BioGPS: 1154 | ||
Pathway | NCI Pathway Interaction Database: CISH | |
KEGG: CISH | ||
REACTOME: CISH | ||
Pathway Commons: CISH | ||
Context | iHOP: CISH | |
ligand binding site mutation search in PubMed: CISH | ||
UCL Cancer Institute: CISH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowOvaryThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLOVTHCA | |
Reference showing the relevant tissue of CISH | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CISH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 1.081633901 | 2.194265901 | -1.112632 | 1.40E-06 | 7.30E-06 |
LUSC | -0.192878962 | 1.720738685 | -1.913617647 | 8.41E-24 | 1.58E-22 |
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TissGene-miRNA for CISH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CISH |
TissGeneSNV for CISH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P197S | LIHC | 1 |
p.H128Y | HNSC | 1 |
p.S239R | SARC | 1 |
p.A191V | STAD | 1 |
p.Q178H | LIHC | 1 |
p.S146F | BLCA | 1 |
p.S163F | BLCA | 1 |
p.S190N | STAD | 1 |
p.R238C | LGG | 1 |
p.D152Y | LUAD | 1 |
p.P53L | SKCM | 1 |
p.A208V | STAD | 1 |
p.F91L | UCEC | 1 |
p.P27L | SKCM | 1 |
p.K205E | LIHC | 1 |
p.E65D | KIRP | 1 |
p.S235N | COAD | 1 |
p.R263C | COAD | 1 |
p.S173N | STAD | 1 |
p.S103F | SKCM | 1 |
p.V247I | SARC | 1 |
p.H111Y | HNSC | 1 |
p.R156G | PAAD | 1 |
p.R139G | PAAD | 1 |
p.A253V | STAD | 1 |
p.L94I | DLBC | 1 |
p.R164K | SKCM | 1 |
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TissGeneCNV for CISH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CISH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE074580 | CISH-CISH | chr3:50644814 | chr3:50644869 | |
Chimerdb3.0 | ChiTaRs | NA | AW438759 | AMMECR1-CISH | chrX:109437660 | chr3:50645044 |
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TissGeneNet for CISH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CISH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CISH |
TissGeneDrug for CISH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CISH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0678222 | Breast Carcinoma | 13 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 12 | BeFree |
umls:C0596263 | Carcinogenesis | 9 | BeFree |
umls:C2239176 | Liver carcinoma | 7 | BeFree |
umls:C0041296 | Tuberculosis | 6 | BeFree,GAD |
umls:C0007137 | Squamous cell carcinoma | 4 | BeFree |
umls:C0007138 | Carcinoma, Transitional Cell | 3 | BeFree |
umls:C0042769 | Virus Diseases | 3 | BeFree |
umls:C0178874 | Tumor Progression | 3 | BeFree |
umls:C0205851 | Germ cell tumor | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0677898 | invasive cancer | 3 | BeFree |
umls:C0851140 | Carcinoma in situ of uterine cervix | 3 | BeFree |
umls:C0003850 | Arteriosclerosis | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree |
umls:C0004153 | Atherosclerosis | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
umls:C0019693 | HIV Infections | 2 | BeFree |
umls:C0021053 | Immune System Diseases | 2 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree |
umls:C0026269 | Mitral Valve Stenosis | 2 | BeFree |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree |
umls:C0028754 | Obesity | 2 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0036631 | Seminoma | 2 | BeFree |
umls:C0279671 | Cervical Squamous Cell Carcinoma | 2 | BeFree |
umls:C0302592 | Cervix carcinoma | 2 | BeFree |
umls:C0349458 | Cervical intraepithelial neoplasia grade 1 | 2 | BeFree |
umls:C0878500 | Intraepithelial Neoplasia | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C0003469 | Anxiety Disorders | 1 | BeFree |
umls:C0004610 | Bacteremia | 1 | BeFree,GAD |
umls:C0004712 | Balo's Concentric Sclerosis | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
umls:C0007121 | Bronchogenic Carcinoma | 1 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
umls:C0013884 | Filarial Elephantiases | 1 | BeFree |
umls:C0014077 | Leukoencephalitis, Acute Hemorrhagic | 1 | BeFree |
umls:C0014378 | Enterovirus Infections | 1 | BeFree |
umls:C0018801 | Heart failure | 1 | BeFree |
umls:C0018802 | Congestive heart failure | 1 | BeFree |
umls:C0019163 | Hepatitis B | 1 | BeFree |
umls:C0019562 | Von Hippel-Lindau Syndrome | 1 | BeFree |
umls:C0021400 | Influenza | 1 | BeFree |
umls:C0023364 | Leptospirosis | 1 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | LHGDN |
umls:C0023524 | Leukoencephalopathy, Progressive Multifocal | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0024530 | Malaria | 1 | CTD_human,GAD |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0027022 | Myeloproliferative disease | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029134 | Optic Neuritis | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0042164 | Uveitis | 1 | BeFree |
umls:C0042373 | Vascular Diseases | 1 | BeFree |
umls:C0085083 | Ovarian Hyperstimulation Syndrome | 1 | BeFree |
umls:C0085605 | Liver Failure | 1 | BeFree |
umls:C0151650 | Renal fibrosis | 1 | BeFree |
umls:C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
umls:C0206659 | Embryonal Carcinoma | 1 | BeFree |
umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
umls:C0221228 | Comedone | 1 | BeFree |
umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0333875 | High-Grade Squamous Intraepithelial Lesions | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0854917 | Rhabdoid Tumor of the Kidney | 1 | BeFree |
umls:C1112157 | Intrauterine infection | 1 | BeFree |
umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
umls:C1292778 | Chronic myeloproliferative disorder | 1 | BeFree |
umls:C1334177 | Infiltrating Cervical Carcinoma | 1 | BeFree |
umls:C2745900 | Promyelocytic leukemia | 1 | BeFree |
umls:C2921627 | Clinically isolated syndrome | 1 | BeFree |
umls:C1834752 | MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 0 | CTD_human |