 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for FAM46B |
 Gene summary |
| Basic gene information | Gene symbol | FAM46B |
| Gene name | family with sequence similarity 46, member B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1p36.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_052943.3, | |
| Description | protein FAM46B | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000158246 | ||
| HPRD : 16882 | ||
| Vega : OTTHUMG00000004278 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FAM46B | |
| BioGPS: 115572 | ||
| Pathway | NCI Pathway Interaction Database: FAM46B | |
| KEGG: FAM46B | ||
| REACTOME: FAM46B | ||
| Pathway Commons: FAM46B | ||
| Context | iHOP: FAM46B | |
| ligand binding site mutation search in PubMed: FAM46B | ||
| UCL Cancer Institute: FAM46B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCASKCM | |
| Reference showing the relevant tissue of FAM46B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for FAM46B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.492851575 | 0.384673425 | -2.877525 | 7.85E-11 | 9.26E-10 |
| THCA | -1.144207137 | 0.622997948 | -1.767205085 | 7.89E-13 | 7.19E-12 |
| BLCA | -1.985020161 | 1.855537734 | -3.840557895 | 1.11E-07 | 6.33E-06 |
| KIRC | -3.035108172 | -0.087930395 | -2.947177778 | 5.25E-23 | 5.23E-22 |
| HNSC | 1.975536143 | 3.675396608 | -1.699860465 | 6.74E-06 | 4.03E-05 |
| PRAD | -0.569499412 | 1.019629435 | -1.589128846 | 1.82E-10 | 3.78E-09 |
| LUAD | -1.015625605 | 1.960481291 | -2.976106897 | 2.20E-29 | 2.08E-27 |
| COAD | -2.933859027 | -0.55848595 | -2.375373077 | 3.35E-06 | 1.69E-05 |
| LUSC | -0.382281048 | 1.767511109 | -2.149792157 | 3.28E-13 | 1.60E-12 |
| STAD | -1.084626575 | 1.02818905 | -2.112815625 | 0.00108 | 0.005648651 |
| KICH | -0.93645995 | 0.71650405 | -1.652964 | 0.000316 | 0.000756204 |
| Top |
| TissGene-miRNA for FAM46B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-19b-3p | MIMAT0000074 | 0.042 | -0.27 | 56 |
| Top |
| TissGeneMut for FAM46B |
| TissGeneSNV for FAM46B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T20K | ACC | 2 |
| p.P77L | SKCM | 2 |
| p.C180R | OV | 1 |
| p.R262Q | STAD | 1 |
| p.R269H | UCEC | 1 |
| p.S65N | LUAD | 1 |
| p.C232F | LUAD | 1 |
| p.Q220H | LUAD | 1 |
| p.P45L | SKCM | 1 |
| p.W421X | THYM | 1 |
| p.R73H | COAD | 1 |
| p.D396N | COAD | 1 |
| p.E248K | LUAD | 1 |
| p.R293Q | UCEC | 1 |
| p.E171Q | COAD | 1 |
| p.D312N | KIRP | 1 |
| p.D224N | UCEC | 1 |
| p.V265I | LUAD | 1 |
| p.R291W | CESC | 1 |
| p.R135H | UCEC | 1 |
| p.R105W | HNSC | 1 |
| p.R320W | KIRP | 1 |
| p.R135H | LGG | 1 |
| p.C181R | UCEC | 1 |
| p.W187* | SKCM | 1 |
| p.F212Y | KIRP | 1 |
| p.R291W | BLCA | 1 |
| p.R269H | STAD | 1 |
| p.V146A | PAAD | 1 |
| p.G74V | BLCA | 1 |
| p.Y251C | UCEC | 1 |
| p.E248K | BLCA | 1 |
| p.G46* | HNSC | 1 |
| Top |
| TissGeneCNV for FAM46B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for FAM46B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for FAM46B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| FAM46B, ATXN1, DAZAP2 (tumor) | FAM46B, ATXN1, DAZAP2 (normal) |
 |  |
| Top |
| TissGeneProg for FAM46B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for FAM46B |
| TissGeneDrug for FAM46B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for FAM46B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |