 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for C12orf56 |
 Gene summary |
| Basic gene information | Gene symbol | C12orf56 |
| Gene name | chromosome 12 open reading frame 56 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12q14.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099676.2, NM_001170633.1, | |
| Description | uncharacterized protein C12orf56 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C12orf56 | |
| BioGPS: 115749 | ||
| Pathway | NCI Pathway Interaction Database: C12orf56 | |
| KEGG: C12orf56 | ||
| REACTOME: C12orf56 | ||
| Pathway Commons: C12orf56 | ||
| Context | iHOP: C12orf56 | |
| ligand binding site mutation search in PubMed: C12orf56 | ||
| UCL Cancer Institute: C12orf56 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of C12orf56 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for C12orf56 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -1.156567442 | -3.065160545 | 1.908593103 | 1.44E-07 | 5.51E-07 |
| KICH | -2.103507373 | 0.726696627 | -2.830204 | 1.47E-06 | 5.42E-06 |
| KIRC | -1.190649817 | 0.500607127 | -1.691256944 | 7.00E-06 | 1.66E-05 |
| LUSC | 1.639403451 | -3.062008314 | 4.701411765 | 1.10E-19 | 1.25E-18 |
| THCA | -1.573613 | -3.019321474 | 1.445708475 | 1.91E-10 | 1.23E-09 |
| ESCA | 1.081617355 | -1.866082645 | 2.9477 | 0.00476 | 0.03832 |
| LIHC | -2.076097373 | -3.230425373 | 1.154328 | 0.00063 | 0.001789297 |
| KIRP | -1.363924123 | 0.493222752 | -1.857146875 | 0.000174 | 0.0005605 |
| Top |
| TissGene-miRNA for C12orf56 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for C12orf56 |
| TissGeneSNV for C12orf56 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D392N | SKCM | 3 |
| p.P128L | SKCM | 2 |
| p.G504E | SKCM | 1 |
| p.A2T | STAD | 1 |
| p.P10S | LUAD | 1 |
| p.E115* | UCEC | 1 |
| p.R429H | UCEC | 1 |
| p.K327I | SKCM | 1 |
| p.Q538E | HNSC | 1 |
| p.A576S | LGG | 1 |
| p.R12H | ESCA | 1 |
| p.R104C | BLCA | 1 |
| p.E411D | READ | 1 |
| p.G507R | SKCM | 1 |
| p.P89L | HNSC | 1 |
| p.E426* | HNSC | 1 |
| p.K133T | READ | 1 |
| p.S190Y | UCEC | 1 |
| p.E424K | SKCM | 1 |
| p.N582D | SKCM | 1 |
| p.D404N | BLCA | 1 |
| p.P434L | HNSC | 1 |
| p.A199S | UCEC | 1 |
| p.V379A | STAD | 1 |
| p.N234S | UCEC | 1 |
| p.P594L | HNSC | 1 |
| p.I106T | STAD | 1 |
| p.D244N | BLCA | 1 |
| p.R402K | SKCM | 1 |
| p.N442S | KIRC | 1 |
| p.P609H | LGG | 1 |
| p.A435T | UCEC | 1 |
| p.E264Q | LUAD | 1 |
| p.L157Q | LIHC | 1 |
| p.E424Q | LUAD | 1 |
| p.R104C | SKCM | 1 |
| p.G247A | CESC | 1 |
| p.S235T | ESCA | 1 |
| p.R580M | COAD | 1 |
| p.R123S | BRCA | 1 |
| p.P527S | SKCM | 1 |
| p.E616K | KICH | 1 |
| p.H130Y | SKCM | 1 |
| p.Q388E | CESC | 1 |
| p.R429C | ESCA | 1 |
| p.D96Y | UCEC | 1 |
| p.R402K | COAD | 1 |
| p.A514D | COAD | 1 |
| p.L25M | BLCA | 1 |
| p.R269H | UCEC | 1 |
| p.V465M | LGG | 1 |
| p.K117T | BRCA | 1 |
| p.E325V | LUAD | 1 |
| Top |
| TissGeneCNV for C12orf56 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for C12orf56 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0AM-01A | TBK1-C12orf56 | Out-of-frame | Chr12:64868170 | Chr12:64746836 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0DD-01A | PPM1H-C12orf56 | In-frame | Chr12:63060958 | Chr12:64671583 |
| TCGAfusionPortal | PRADA | OV | TCGA-09-2051-01A | XPOT-C12orf56 | In-frame | Chr12:64803875 | Chr12:64746836 |
| Top |
| TissGeneNet for C12orf56 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for C12orf56 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for C12orf56 |
| TissGeneDrug for C12orf56 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for C12orf56 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |