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TissGeneSummary for OLIG1 |
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Basic gene information | Gene symbol | OLIG1 |
Gene name | oligodendrocyte transcription factor 1 | |
Synonyms | BHLHB6|BHLHE21 | |
Cytomap | UCSC genome browser: 21q22.11 | |
Type of gene | protein-coding | |
RefGenes | NM_138983.2, | |
Description | basic domain, helix-loop-helix protein, class B, 6class B basic helix-loop-helix protein 6class E basic helix-loop-helix protein 21oligo1oligodendrocyte lineage transcription factor 1oligodendrocyte-specific bHLH transcription factor 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606385 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184221 | ||
HPRD : 07333 | ||
Vega : OTTHUMG00000065064 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OLIG1 | |
BioGPS: 116448 | ||
Pathway | NCI Pathway Interaction Database: OLIG1 | |
KEGG: OLIG1 | ||
REACTOME: OLIG1 | ||
Pathway Commons: OLIG1 | ||
Context | iHOP: OLIG1 | |
ligand binding site mutation search in PubMed: OLIG1 | ||
UCL Cancer Institute: OLIG1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of OLIG1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for OLIG1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -0.209372206 | 1.909281961 | -2.118654167 | 1.48E-08 | 4.40E-08 |
LUAD | -1.633718518 | -0.335553001 | -1.298165517 | 1.41E-05 | 4.05E-05 |
KIRP | -1.689943733 | 2.509121892 | -4.199065625 | 1.40E-12 | 2.19E-11 |
LUSC | -2.225014934 | -0.437077679 | -1.787937255 | 6.75E-09 | 2.16E-08 |
KICH | 4.261172517 | 2.703356517 | 1.557816 | 0.0181 | 0.030852591 |
HNSC | -3.075559576 | -1.88029446 | -1.195265116 | 0.000219 | 0.000886241 |
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TissGene-miRNA for OLIG1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OLIG1 |
TissGeneSNV for OLIG1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E100Q | KIRP | 1 |
p.S56P | MESO | 1 |
p.K109N | CESC | 1 |
p.K109N | PAAD | 1 |
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TissGeneCNV for OLIG1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OLIG1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OLIG1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OLIG1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OLIG1 |
TissGeneDrug for OLIG1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OLIG1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026769 | Multiple Sclerosis | 3 | BeFree,LHGDN |
umls:C0013080 | Down Syndrome | 2 | BeFree,CTD_human |
umls:C0017636 | Glioblastoma | 2 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C0028945 | oligodendroglioma | 2 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 2 | BeFree |
umls:C0001925 | Albuminuria | 1 | GAD |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0017922 | Glycogen Storage Disease Type III | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0028768 | Obsessive-Compulsive Disorder | 1 | BeFree |
umls:C0029421 | Osteochondritis Dissecans | 1 | BeFree |
umls:C0040517 | Gilles de la Tourette syndrome | 1 | BeFree |
umls:C0041696 | Unipolar Depression | 1 | BeFree |
umls:C0151786 | Muscle Weakness | 1 | CTD_human |
umls:C0334579 | Anaplastic astrocytoma | 1 | BeFree |
umls:C0334590 | Anaplastic Oligodendroglioma | 1 | BeFree |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree |