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| TissGeneSummary for APOA5 |
 Gene summary |
| Basic gene information | Gene symbol | APOA5 |
| Gene name | apolipoprotein A-V | |
| Synonyms | APOAV|RAP3 | |
| Cytomap | UCSC genome browser: 11q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001166598.1, NM_052968.4, | |
| Description | apo-AVapolipoprotein A5regeneration-associated protein 3 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 606368 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000110243 | ||
| HPRD : 06966 | ||
| Vega : OTTHUMG00000046116 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_APOA5 | |
| BioGPS: 116519 | ||
| Pathway | NCI Pathway Interaction Database: APOA5 | |
| KEGG: APOA5 | ||
| REACTOME: APOA5 | ||
| Pathway Commons: APOA5 | ||
| Context | iHOP: APOA5 | |
| ligand binding site mutation search in PubMed: APOA5 | ||
| UCL Cancer Institute: APOA5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of APOA5 | ||
| Description by TissGene annotations | Cancer gene TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006641 | triglyceride metabolic process | 11588264 | GO:0006869 | lipid transport | 15178420 | GO:0010898 | positive regulation of triglyceride catabolic process | 18635818 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling | 18635818 | GO:0042632 | cholesterol homeostasis | 19121291 | GO:0045723 | positive regulation of fatty acid biosynthetic process | 18635818 | GO:0050996 | positive regulation of lipid catabolic process | 16806135 | GO:0051006 | positive regulation of lipoprotein lipase activity | 15178420 | GO:0055090 | acylglycerol homeostasis | 11588264 | GO:0070328 | triglyceride homeostasis | 19121291 | GO:0006641 | triglyceride metabolic process | 11588264 | GO:0006869 | lipid transport | 15178420 | GO:0010898 | positive regulation of triglyceride catabolic process | 18635818 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling | 18635818 | GO:0042632 | cholesterol homeostasis | 19121291 | GO:0045723 | positive regulation of fatty acid biosynthetic process | 18635818 | GO:0050996 | positive regulation of lipid catabolic process | 16806135 | GO:0051006 | positive regulation of lipoprotein lipase activity | 15178420 | GO:0055090 | acylglycerol homeostasis | 11588264 | GO:0070328 | triglyceride homeostasis | 19121291 |
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| TissGeneExp for APOA5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.801681297 | -0.380508748 | -1.421172549 | 6.37E-15 | 3.88E-14 |
| LUAD | -1.624812095 | -0.077277613 | -1.547534483 | 3.53E-14 | 3.27E-13 |
| LIHC | 9.905802663 | 11.84299466 | -1.937192 | 6.91E-06 | 3.03E-05 |
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| TissGene-miRNA for APOA5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for APOA5 |
| TissGeneSNV for APOA5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E61D | PRAD | 1 |
| p.R179C | SKCM | 1 |
| p.R282H | UCS | 1 |
| p.R271H | STAD | 1 |
| p.P326Q | LUAD | 1 |
| p.H353Y | BLCA | 1 |
| p.G364E | SKCM | 1 |
| p.R106C | SKCM | 1 |
| p.H379D | UCEC | 1 |
| p.A141P | STAD | 1 |
| p.T184N | LUAD | 1 |
| p.E208Q | BLCA | 1 |
| p.Q161H | STAD | 1 |
| p.H353D | UCEC | 1 |
| p.R343H | ESCA | 1 |
| p.G269V | STAD | 1 |
| p.E168K | SKCM | 1 |
| p.R179H | COAD | 1 |
| p.L142M | THYM | 1 |
| p.Q358K | THYM | 1 |
| p.V144M | ESCA | 1 |
| p.W348L | LUAD | 1 |
| p.G203R | LIHC | 1 |
| p.S197N | SKCM | 1 |
| p.Q127X | THYM | 1 |
| p.R284* | HNSC | 1 |
| p.G211S | LUSC | 1 |
| p.Y220H | LUSC | 1 |
| p.S16L | HNSC | 1 |
| p.L15F | SKCM | 1 |
| p.Q358K | SARC | 1 |
| p.V118M | STAD | 1 |
| p.R106H | LUAD | 1 |
| p.E149K | LUAD | 1 |
| p.E149K | SKCM | 1 |
| p.L117M | LUAD | 1 |
| p.S19L | COAD | 1 |
| p.E268K | SKCM | 1 |
| p.P76T | LUAD | 1 |
| p.H356N | BLCA | 1 |
| p.V7M | PAAD | 1 |
| p.T184P | LUAD | 1 |
| p.A23T | COAD | 1 |
| p.R284* | SARC | 1 |
| p.V180M | COAD | 1 |
| p.R204H | PAAD | 1 |
| p.R204C | KIRC | 1 |
| p.A140V | GBM | 1 |
| p.G269E | LUAD | 1 |
| p.L71M | PAAD | 1 |
| p.V7M | UCEC | 1 |
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| TissGeneCNV for APOA5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for APOA5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JG-01B | BUD13-APOA5 | Out-of-frame | Chr11:116631451 | Chr11:116661783 |
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| TissGeneNet for APOA5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| COAD (tumor) | COAD (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| KICH (tumor) | KICH (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| KIRP (tumor) | KIRP (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| STAD (tumor) | STAD (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| THCA (tumor) | THCA (normal) |
| APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (tumor) | APOA5, FAS, THRB, SMARCD1, USF1, USF2, PPARA, NR1H4, RAB5B (normal) |
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| TissGeneProg for APOA5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for APOA5 |
| TissGeneDrug for APOA5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for APOA5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010068 | Coronary heart disease | 37 | BeFree,GAD,LHGDN |
| umls:C0524620 | Metabolic Syndrome X | 35 | BeFree,GAD,GWASCAT |
| umls:C0020557 | Hypertriglyceridemia | 33 | CTD_human,GAD,LHGDN,RGD |
| umls:C0010054 | Coronary Arteriosclerosis | 31 | BeFree,GAD |
| umls:C1522137 | Hypertriglyceridemia result | 26 | GAD |
| umls:C1956346 | Coronary Artery Disease | 25 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 20 | BeFree,GAD,LHGDN |
| umls:C0028754 | Obesity | 20 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 19 | BeFree,GAD |
| umls:C0242339 | Dyslipidemias | 18 | BeFree,GAD,LHGDN |
| umls:C0004153 | Atherosclerosis | 10 | BeFree,GAD,LHGDN |
| umls:C0003850 | Arteriosclerosis | 8 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 8 | BeFree,GAD,LHGDN |
| umls:C0020473 | Hyperlipidemia | 8 | BeFree,GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 8 | BeFree,GAD,LHGDN |
| umls:C0027051 | Myocardial Infarction | 7 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 7 | BeFree,GAD |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 7 | BeFree |
| umls:C0011847 | Diabetes | 6 | BeFree |
| umls:C0023817 | Hyperlipoproteinemia Type I | 6 | BeFree,GAD |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 5 | BeFree,LHGDN |
| umls:C0019693 | HIV Infections | 4 | BeFree,GAD |
| umls:C0497406 | Overweight | 4 | BeFree,GAD |
| umls:C0007785 | Cerebral Infarction | 3 | BeFree,GAD |
| umls:C0020479 | Hyperlipoproteinemia Type III | 3 | BeFree,CTD_human,GAD |
| umls:C0020538 | Hypertensive disease | 3 | BeFree,GAD |
| umls:C0002395 | Alzheimer's Disease | 2 | GAD |
| umls:C0007786 | Brain Ischemia | 2 | GAD |
| umls:C0020443 | Hypercholesterolemia | 2 | GAD |
| umls:C0020476 | Hyperlipoproteinemias | 2 | BeFree,GAD,LHGDN |
| umls:C0021368 | Inflammation | 2 | GAD,LHGDN |
| umls:C0021655 | Insulin Resistance | 2 | GAD |
| umls:C0025517 | Metabolic Diseases | 2 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 2 | BeFree,GAD |
| umls:C0154251 | Lipid Metabolism Disorders | 2 | BeFree,GAD |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0577631 | Carotid Atherosclerosis | 2 | BeFree |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007771 | Intracranial Arteriosclerosis | 1 | GAD |
| umls:C0007820 | Cerebrovascular Disorders | 1 | GAD |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree,LHGDN |
| umls:C0015695 | Fatty Liver | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | LHGDN |
| umls:C0020480 | Hyperlipoproteinemia Type IV | 1 | BeFree,CTD_human,ORPHANET |
| umls:C0020481 | Hyperlipoproteinemia Type V | 1 | BeFree,CLINVAR,CTD_human,ORPHANET |
| umls:C0020676 | Hypothyroidism | 1 | RGD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | GAD |
| umls:C0032962 | Pregnancy Complications | 1 | GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0155733 | Atherosclerosis of aorta | 1 | BeFree |
| umls:C0311277 | Obesity, Abdominal | 1 | GAD |
| umls:C0342886 | Primary hypertriglyceridemia | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0518010 | body mass | 1 | GAD |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2362324 | Pediatric Obesity | 1 | BeFree |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
| umls:C2911645 | Weight Loss Adverse Event | 1 | GAD |
| umls:C2931862 | Familial hyperchylomicronemia syndrome | 1 | BeFree |
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