TissGeneSummary for MUCL1 |
Gene summary |
Basic gene information | Gene symbol | MUCL1 |
Gene name | mucin-like 1 | |
Synonyms | SBEM | |
Cytomap | UCSC genome browser: 12q | |
Type of gene | protein-coding | |
RefGenes | NM_058173.2, | |
Description | mucin-like protein 1small breast epithelial mucin | |
Modification date | 20141207 | |
dbXrefs | MIM : 610857 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172551 | ||
HPRD : 17290 | ||
Vega : OTTHUMG00000169815 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUCL1 | |
BioGPS: 118430 | ||
Pathway | NCI Pathway Interaction Database: MUCL1 | |
KEGG: MUCL1 | ||
REACTOME: MUCL1 | ||
Pathway Commons: MUCL1 | ||
Context | iHOP: MUCL1 | |
ligand binding site mutation search in PubMed: MUCL1 | ||
UCL Cancer Institute: MUCL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASKCM | |
Reference showing the relevant tissue of MUCL1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MUCL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 4.931628361 | 8.481735378 | -3.550107018 | 1.37E-09 | 4.83E-09 |
LUSC | 1.074876503 | -1.21740585 | 2.292282353 | 7.71E-07 | 1.96E-06 |
STAD | -1.197344392 | -2.326244392 | 1.1289 | 0.00407 | 0.016463004 |
KICH | 1.064911483 | -1.852648517 | 2.91756 | 0.000123 | 0.00031559 |
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TissGene-miRNA for MUCL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MUCL1 |
TissGeneSNV for MUCL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D39N | SKCM | 2 |
p.W79* | SKCM | 2 |
p.E40K | READ | 1 |
p.F3L | BLCA | 1 |
p.W79X | SKCM | 1 |
p.T59N | LUAD | 1 |
p.W79G | SKCM | 1 |
p.P22L | THYM | 1 |
p.P22L | LGG | 1 |
p.M1I | SKCM | 1 |
p.P22L | PRAD | 1 |
p.P27L | SKCM | 1 |
p.G11E | SKCM | 1 |
p.P22L | SKCM | 1 |
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TissGeneCNV for MUCL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MUCL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | OV | TCGA-29-1702-01A | WHSC1L1-MUCL1 | 5'UTR-CDS | chr8:38239316 | chr12:55250553 |
Chimerdb3.0 | FusionScan | OV | TCGA-29-1702-01A | WHSC1L1-MUCL1 | 5'UTR-CDS | chr8:38239316 | chr12:55248899 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-91-6840-01A | LARP4-MUCL1 | Out-of-Frame | chr12:50794811 | chr12:55248899 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-91-6840-01A | LARP4-MUCL1 | Out-of-Frame | chr12:50794811 | chr12:55250553 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-91-6840-01A | LARP4-MUCL1 | Out-of-Frame | chr12:50794810 | chr12:55250553 |
Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-91-6840-01A | LARP4-MUCL1 | Out-of-Frame | chr12:50794808 | chr12:55248897 |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JK-01A | MUCL1-CHI3L2 | 3UTR-5UTR | Chr12:55252171 | Chr1:111772314 |
TCGAfusionPortal | PRADA | HNSC | TCGA-DQ-7591-01A | CS-MUCL1 | NA | Chr12:56685415 | Chr12:55251977 |
TCGAfusionPortal | PRADA | LUAD | TCGA-53-7813-01A | MAP4K4-MUCL1 | Out-of-frame | Chr2:102315000 | Chr12:55248900 |
TCGAfusionPortal | PRADA | LUAD | TCGA-91-6840-01A | LARP4-MUCL1 | Out-of-frame | Chr12:50794811 | Chr12:55248900 |
TCGAfusionPortal | PRADA | OV | TCGA-29-1702-01A | WHSC1L1-MUCL1 | 5UTR-CDS | Chr8:38239317 | Chr12:55248900 |
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TissGeneNet for MUCL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MUCL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MUCL1 |
TissGeneDrug for MUCL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MUCL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 8 | BeFree |
umls:C0678222 | Breast Carcinoma | 7 | BeFree |
umls:C1458155 | Mammary Neoplasms | 4 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
umls:C1176475 | Ductal Carcinoma | 2 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |