TissGeneSummary for CCDC38 |
Gene summary |
Basic gene information | Gene symbol | CCDC38 |
Gene name | coiled-coil domain containing 38 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_182496.2, | |
Description | coiled-coil domain-containing protein 38 | |
Modification date | 20141205 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165972 | ||
HPRD : 08268 | ||
Vega : OTTHUMG00000170352 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC38 | |
BioGPS: 120935 | ||
Pathway | NCI Pathway Interaction Database: CCDC38 | |
KEGG: CCDC38 | ||
REACTOME: CCDC38 | ||
Pathway Commons: CCDC38 | ||
Context | iHOP: CCDC38 | |
ligand binding site mutation search in PubMed: CCDC38 | ||
UCL Cancer Institute: CCDC38 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC38 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC38 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC38 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC38 |
TissGeneSNV for CCDC38 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S423X | ESCA | 2 |
p.E420* | SKCM | 1 |
p.L5V | STAD | 1 |
p.E550K | SKCM | 1 |
p.D447N | ESCA | 1 |
p.Q188* | SKCM | 1 |
p.A248E | LUAD | 1 |
p.T46M | UCEC | 1 |
p.P293Q | LUAD | 1 |
p.Q188X | SKCM | 1 |
p.S63L | SKCM | 1 |
p.P95T | ESCA | 1 |
p.P301S | SKCM | 1 |
p.S244* | HNSC | 1 |
p.L35R | STAD | 1 |
p.E167* | LUAD | 1 |
p.L388I | UCEC | 1 |
p.D104N | STAD | 1 |
p.A243V | STAD | 1 |
p.M66I | SKCM | 1 |
p.A237S | HNSC | 1 |
p.L35I | STAD | 1 |
p.S228F | SKCM | 1 |
p.L154F | SKCM | 1 |
p.L154I | LUAD | 1 |
p.D424N | BLCA | 1 |
p.E123Q | CESC | 1 |
p.F112C | UCEC | 1 |
p.F561Y | UCEC | 1 |
p.M198I | LUSC | 1 |
p.D118N | SKCM | 1 |
p.P95L | SARC | 1 |
p.K380Q | SKCM | 1 |
p.Q378* | KIRP | 1 |
p.Q58* | UCEC | 1 |
p.A406S | READ | 1 |
p.S85* | UCEC | 1 |
p.E151D | CESC | 1 |
p.L388I | COAD | 1 |
p.F136C | COAD | 1 |
p.A243T | SKCM | 1 |
p.F86C | READ | 1 |
p.E40K | BLCA | 1 |
p.D451G | COAD | 1 |
p.E491Q | BLCA | 1 |
p.A202T | UCEC | 1 |
p.L35S | STAD | 1 |
p.K44T | LUSC | 1 |
p.A94T | UCEC | 1 |
p.F89C | THCA | 1 |
p.E123_splice | LUSC | 1 |
p.R493W | LUSC | 1 |
p.H110R | STAD | 1 |
p.A175T | LUSC | 1 |
p.M487I | BLCA | 1 |
p.R299H | THYM | 1 |
p.H110Q | READ | 1 |
p.R107W | SKCM | 1 |
p.E272Q | BLCA | 1 |
p.F112C | CESC | 1 |
p.R166* | SKCM | 1 |
p.Q378X | KIRP | 1 |
p.S263* | LUAD | 1 |
p.I28M | BLCA | 1 |
p.E45D | HNSC | 1 |
p.L330M | CESC | 1 |
p.D329N | CESC | 1 |
p.R486K | SKCM | 1 |
p.I250V | UCEC | 1 |
p.Q181H | STAD | 1 |
p.E420X | SKCM | 1 |
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TissGeneCNV for CCDC38 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC38 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-05-4427-01A | NTN4-CCDC38 | Out-of-frame | Chr12:96180717 | Chr12:96292243 |
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TissGeneNet for CCDC38 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC38 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC38 |
TissGeneDrug for CCDC38 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC38 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C3160731 | Pulmonary function (finding) | 2 | GWASCAT |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |