TissGeneSummary for FAM186A |
Gene summary |
Basic gene information | Gene symbol | FAM186A |
Gene name | family with sequence similarity 186, member A | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001145475.1, | |
Description | protein FAM186A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000185958 | ||
Vega : OTTHUMG00000167889 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM186A | |
BioGPS: 121006 | ||
Pathway | NCI Pathway Interaction Database: FAM186A | |
KEGG: FAM186A | ||
REACTOME: FAM186A | ||
Pathway Commons: FAM186A | ||
Context | iHOP: FAM186A | |
ligand binding site mutation search in PubMed: FAM186A | ||
UCL Cancer Institute: FAM186A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM186A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM186A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM186A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM186A |
TissGeneSNV for FAM186A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T1458P | BRCA | 4 |
p.A1500V | UCEC | 3 |
p.E1598A | BRCA | 2 |
p.F1315L | LIHC | 2 |
p.H2228Q | COAD | 1 |
p.N686T | READ | 1 |
p.K1282Q | THYM | 1 |
p.E997Q | UCEC | 1 |
p.S642T | UCEC | 1 |
p.K623T | UCEC | 1 |
p.T1458P | UCEC | 1 |
p.S90L | READ | 1 |
p.M794I | READ | 1 |
p.E1564G | ESCA | 1 |
p.D2084H | UCEC | 1 |
p.S1626P | BRCA | 1 |
p.T2020I | KIRP | 1 |
p.A1502D | COAD | 1 |
p.G1360R | ACC | 1 |
p.T1893S | BRCA | 1 |
p.A1500V | KIRP | 1 |
p.V1205I | TGCT | 1 |
p.T1124I | UCEC | 1 |
p.P1182T | UCEC | 1 |
p.S472C | BRCA | 1 |
p.T1377P | LIHC | 1 |
p.R79W | COAD | 1 |
p.M2193I | COAD | 1 |
p.L36F | UCEC | 1 |
p.A2305E | THYM | 1 |
p.A1696V | UCEC | 1 |
p.R61X | COAD | 1 |
p.A1094N | BRCA | 1 |
p.S1904C | ESCA | 1 |
p.P1155Q | UCEC | 1 |
p.S1828Y | COAD | 1 |
p.G1492E | LIHC | 1 |
p.S91Y | BRCA | 1 |
p.Q317E | LIHC | 1 |
p.I1577V | COAD | 1 |
p.A2111V | DLBC | 1 |
p.E2306D | UCEC | 1 |
p.S664R | KIRC | 1 |
p.Q1594* | CESC | 1 |
p.T1334A | TGCT | 1 |
p.A1596V | COAD | 1 |
p.L956V | COAD | 1 |
p.S1828Y | KIRP | 1 |
p.E2099K | READ | 1 |
p.H2228Q | LGG | 1 |
p.P995S | READ | 1 |
p.E111Q | CESC | 1 |
p.P1155L | LIHC | 1 |
p.E700D | COAD | 1 |
p.P1221H | UCEC | 1 |
p.E707X | READ | 1 |
p.H1367Q | UCEC | 1 |
p.A1478V | UCEC | 1 |
p.T1434P | LIHC | 1 |
p.M315T | LIHC | 1 |
p.E1120G | KIRP | 1 |
p.I2304L | LIHC | 1 |
p.A1670T | UCEC | 1 |
p.P1819S | UCEC | 1 |
p.R2174X | COAD | 1 |
p.E1037D | UCEC | 1 |
p.Q1611L | TGCT | 1 |
p.P29L | UCEC | 1 |
p.E1779* | UCEC | 1 |
p.Q1611L | KIRP | 1 |
p.G1516E | LIHC | 1 |
p.I224F | ESCA | 1 |
p.H2228Q | SKCM | 1 |
p.T618K | UCEC | 1 |
p.K2281R | UCEC | 1 |
p.Y407H | LIHC | 1 |
p.I1589V | COAD | 1 |
p.P1542S | COAD | 1 |
p.K2280N | UCEC | 1 |
p.E1418A | LIHC | 1 |
p.M1397I | KIRP | 1 |
p.E160G | UCEC | 1 |
p.M1397I | LIHC | 1 |
p.A1644G | BRCA | 1 |
p.D139N | BRCA | 1 |
p.E1598A | UCEC | 1 |
p.H1367Q | THYM | 1 |
p.Q869R | BRCA | 1 |
p.T1458P | SARC | 1 |
p.G1252X | COAD | 1 |
p.E863K | CESC | 1 |
p.L1603F | CESC | 1 |
p.R307* | UCEC | 1 |
p.I335M | UCEC | 1 |
p.L2339V | BRCA | 1 |
p.E1418D | LIHC | 1 |
p.S2011* | UCEC | 1 |
p.T1244I | READ | 1 |
p.F446L | UCEC | 1 |
p.Q1582P | LIHC | 1 |
p.E432K | COAD | 1 |
p.M794I | BRCA | 1 |
p.T1377P | SARC | 1 |
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TissGeneCNV for FAM186A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM186A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM186A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM186A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM186A |
TissGeneDrug for FAM186A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM186A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |