TissGeneSummary for CSNK1A1L |
Gene summary |
Basic gene information | Gene symbol | CSNK1A1L |
Gene name | casein kinase 1, alpha 1-like | |
Synonyms | CK1 | |
Cytomap | UCSC genome browser: 13q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_145203.5, | |
Description | CKI-alpha-likecasein kinase I alpha S-likecasein kinase I isoform alpha-like | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000180138 | ||
HPRD : 13095 | ||
Vega : OTTHUMG00000016748 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CSNK1A1L | |
BioGPS: 122011 | ||
Pathway | NCI Pathway Interaction Database: CSNK1A1L | |
KEGG: CSNK1A1L | ||
REACTOME: CSNK1A1L | ||
Pathway Commons: CSNK1A1L | ||
Context | iHOP: CSNK1A1L | |
ligand binding site mutation search in PubMed: CSNK1A1L | ||
UCL Cancer Institute: CSNK1A1L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CSNK1A1L | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CSNK1A1L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CSNK1A1L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CSNK1A1L |
TissGeneSNV for CSNK1A1L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S27F | SKCM | 2 |
p.D140H | BLCA | 1 |
p.I23M | LUAD | 1 |
p.Q68* | LUSC | 1 |
p.P220S | PAAD | 1 |
p.Q320K | CHOL | 1 |
p.E82K | LUAD | 1 |
p.Q320K | LUAD | 1 |
p.T323I | LUAD | 1 |
p.E41K | SKCM | 1 |
p.Y126* | LUAD | 1 |
p.V31I | UVM | 1 |
p.L133I | READ | 1 |
p.F101Y | COAD | 1 |
p.D336H | BLCA | 1 |
p.Y187C | STAD | 1 |
p.L194I | UCEC | 1 |
p.L284I | COAD | 1 |
p.S61R | STAD | 1 |
p.C104R | HNSC | 1 |
p.Y259C | UCEC | 1 |
p.R282H | UVM | 1 |
p.G24R | COAD | 1 |
p.G40S | CESC | 1 |
p.H172Q | LUSC | 1 |
p.E98K | HNSC | 1 |
p.M76V | UCEC | 1 |
p.S5R | LIHC | 1 |
p.L160M | LIHC | 1 |
p.R148H | LIHC | 1 |
p.S25F | PAAD | 1 |
p.D293N | SKCM | 1 |
p.V127M | DLBC | 1 |
p.R282H | LUAD | 1 |
p.E10K | SKCM | 1 |
p.E270Q | LUAD | 1 |
p.R264H | HNSC | 1 |
p.L92V | DLBC | 1 |
p.D202N | LUSC | 1 |
p.P139Q | BRCA | 1 |
p.E98K | SKCM | 1 |
p.E269Q | BLCA | 1 |
p.V12I | STAD | 1 |
p.R21G | LUSC | 1 |
p.T129A | STAD | 1 |
p.Q326H | LUSC | 1 |
p.H180R | STAD | 1 |
p.R148C | LGG | 1 |
p.G94V | LUAD | 1 |
p.P55L | UCEC | 1 |
p.M76V | HNSC | 1 |
p.G24R | STAD | 1 |
p.G265R | LUAD | 1 |
p.R165K | BRCA | 1 |
p.L100F | SKCM | 1 |
p.M144V | PAAD | 1 |
p.E41K | READ | 1 |
p.T146N | UCEC | 1 |
p.R200H | MESO | 1 |
p.Y292H | BRCA | 1 |
p.P174S | SKCM | 1 |
p.P244H | LUAD | 1 |
p.N131S | READ | 1 |
p.E125K | SKCM | 1 |
p.W298L | LUAD | 1 |
p.G70V | ESCA | 1 |
p.Y294* | LUAD | 1 |
p.L284I | UCEC | 1 |
p.H172Y | LGG | 1 |
p.R267H | READ | 1 |
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TissGeneCNV for CSNK1A1L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CSNK1A1L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CSNK1A1L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CSNK1A1L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CSNK1A1L |
TissGeneDrug for CSNK1A1L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CSNK1A1L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |