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| TissGeneSummary for PLA2G4E |
 Gene summary |
| Basic gene information | Gene symbol | PLA2G4E |
| Gene name | phospholipase A2, group IVE | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 15q15.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001080490.1, NM_001206670.1, | |
| Description | cPLA2-epsiloncytosolic phospholipase A2 epsilon | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000188089 | ||
| HPRD : 13510 | ||
| Vega : OTTHUMG00000130371 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLA2G4E | |
| BioGPS: 123745 | ||
| Pathway | NCI Pathway Interaction Database: PLA2G4E | |
| KEGG: PLA2G4E | ||
| REACTOME: PLA2G4E | ||
| Pathway Commons: PLA2G4E | ||
| Context | iHOP: PLA2G4E | |
| ligand binding site mutation search in PubMed: PLA2G4E | ||
| UCL Cancer Institute: PLA2G4E | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of PLA2G4E | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PLA2G4E |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PLA2G4E |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PLA2G4E |
| TissGeneSNV for PLA2G4E |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R649W | SKCM | 2 |
| p.R163Q | SKCM | 2 |
| p.E764K | SKCM | 1 |
| p.P174L | SKCM | 1 |
| p.E493K | SKCM | 1 |
| p.Q608R | UCEC | 1 |
| p.R319W | UCEC | 1 |
| p.H149Y | HNSC | 1 |
| p.R569Q | COAD | 1 |
| p.G30D | SKCM | 1 |
| p.E805K | SKCM | 1 |
| p.E760K | SKCM | 1 |
| p.R466H | ESCA | 1 |
| p.R423C | UCEC | 1 |
| p.R332W | THYM | 1 |
| p.S241Y | BRCA | 1 |
| p.A673V | UCEC | 1 |
| p.G32A | LIHC | 1 |
| p.A100T | LGG | 1 |
| p.P326A | DLBC | 1 |
| p.S707T | SARC | 1 |
| p.V133M | GBM | 1 |
| p.R761* | UCEC | 1 |
| p.P506H | STAD | 1 |
| p.A39G | CESC | 1 |
| p.E211Q | LUAD | 1 |
| p.P749L | SKCM | 1 |
| p.S21G | LIHC | 1 |
| p.E106D | LUAD | 1 |
| p.S450F | THYM | 1 |
| p.E187D | ACC | 1 |
| p.V144A | KIRP | 1 |
| p.R717X | COAD | 1 |
| p.L463I | COAD | 1 |
| p.R332Q | ESCA | 1 |
| p.K164Q | HNSC | 1 |
| p.E188K | SKCM | 1 |
| p.M768I | SKCM | 1 |
| p.P24L | SARC | 1 |
| p.L273F | HNSC | 1 |
| p.L302F | HNSC | 1 |
| p.G544E | SKCM | 1 |
| p.E120* | SKCM | 1 |
| p.S450F | SKCM | 1 |
| p.E803K | CHOL | 1 |
| p.F556L | HNSC | 1 |
| p.R464W | SKCM | 1 |
| p.E187G | LGG | 1 |
| p.V133M | LGG | 1 |
| p.R394C | UCEC | 1 |
| p.R643Q | SKCM | 1 |
| p.E597K | SKCM | 1 |
| p.E469K | SKCM | 1 |
| p.E615* | UCEC | 1 |
| p.R440W | HNSC | 1 |
| p.P535H | STAD | 1 |
| p.A702V | PRAD | 1 |
| p.R411W | HNSC | 1 |
| p.R259H | UCEC | 1 |
| p.R205Q | KIRC | 1 |
| p.E857D | UCS | 1 |
| p.R770* | UCEC | 1 |
| p.E822K | SKCM | 1 |
| p.E461K | SKCM | 1 |
| p.E135D | LUAD | 1 |
| p.E26D | COAD | 1 |
| p.I374M | SARC | 1 |
| p.R853W | STAD | 1 |
| p.Q439R | LUAD | 1 |
| p.L646F | SKCM | 1 |
| p.A259D | HNSC | 1 |
| p.S467N | LIHC | 1 |
| p.L849F | PAAD | 1 |
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| TissGeneCNV for PLA2G4E |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PLA2G4E |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PLA2G4E |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for PLA2G4E |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PLA2G4E |
| TissGeneDrug for PLA2G4E |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PLA2G4E |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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