TissGeneSummary for HSF5 |
Gene summary |
Basic gene information | Gene symbol | HSF5 |
Gene name | heat shock transcription factor family member 5 | |
Synonyms | HSF 5|HSTF 5 | |
Cytomap | UCSC genome browser: 17q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001080439.2, | |
Description | heat shock factor protein 5 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000176160 | ||
Vega : OTTHUMG00000179078 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HSF5 | |
BioGPS: 124535 | ||
Pathway | NCI Pathway Interaction Database: HSF5 | |
KEGG: HSF5 | ||
REACTOME: HSF5 | ||
Pathway Commons: HSF5 | ||
Context | iHOP: HSF5 | |
ligand binding site mutation search in PubMed: HSF5 | ||
UCL Cancer Institute: HSF5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HSF5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HSF5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.074366781 | 0.131350866 | -1.205717647 | 9.45E-14 | 4.94E-13 |
BLCA | -1.431299392 | -0.273204655 | -1.158094737 | 6.94E-06 | 0.000144248 |
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TissGene-miRNA for HSF5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HSF5 |
TissGeneSNV for HSF5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P254S | SKCM | 2 |
p.P262L | LUAD | 2 |
p.S427I | LUAD | 1 |
p.H576N | COAD | 1 |
p.D198A | PRAD | 1 |
p.E541Q | LUAD | 1 |
p.R223W | SKCM | 1 |
p.Q399X | COAD | 1 |
p.L108P | HNSC | 1 |
p.V379L | KIRP | 1 |
p.E47K | BLCA | 1 |
p.S384C | BLCA | 1 |
p.G236E | SKCM | 1 |
p.E70K | SKCM | 1 |
p.G98W | LUAD | 1 |
p.A160T | LUAD | 1 |
p.P342S | SKCM | 1 |
p.R197Q | STAD | 1 |
p.H335N | ESCA | 1 |
p.L142R | BLCA | 1 |
p.S332F | SKCM | 1 |
p.G34D | STAD | 1 |
p.L130F | SKCM | 1 |
p.Q483H | SKCM | 1 |
p.F339L | ESCA | 1 |
p.R197* | UCEC | 1 |
p.R526H | STAD | 1 |
p.Q377* | HNSC | 1 |
p.S405F | SKCM | 1 |
p.S473N | COAD | 1 |
p.P53L | SKCM | 1 |
p.E490X | THYM | 1 |
p.P15L | SKCM | 1 |
p.P469L | CHOL | 1 |
p.P342L | HNSC | 1 |
p.N518K | STAD | 1 |
p.G88D | SKCM | 1 |
p.Q476E | LGG | 1 |
p.R90C | UCEC | 1 |
p.R31L | LUAD | 1 |
p.E506D | LUSC | 1 |
p.P354S | STAD | 1 |
p.Q377* | BRCA | 1 |
p.W231* | SKCM | 1 |
p.S453C | BLCA | 1 |
p.S572P | LUAD | 1 |
p.G141S | STAD | 1 |
p.S546R | ESCA | 1 |
p.R196C | SKCM | 1 |
p.A423P | UCEC | 1 |
p.P328T | LUAD | 1 |
p.Q43* | KIRP | 1 |
p.P114L | LUAD | 1 |
p.S245Y | UCEC | 1 |
p.R193Q | PAAD | 1 |
p.G543R | LUAD | 1 |
p.S384F | SKCM | 1 |
p.R223W | LUAD | 1 |
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TissGeneCNV for HSF5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HSF5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK097630 | HSF5-TRAPPC4 | chr17:56544311 | chr11:118890877 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-A7RE-11A | TUBD1-HSF5 | Out-of-Frame | chr17:57963443 | chr17:56499791 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A0J5-01A | NOL11-HSF5 | Out-of-frame | Chr17:65739702 | Chr17:56499791 |
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TissGeneNet for HSF5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HSF5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HSF5 |
TissGeneDrug for HSF5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HSF5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 1 | BeFree |