TissGeneSummary for CNTD1 |
Gene summary |
Basic gene information | Gene symbol | CNTD1 |
Gene name | cyclin N-terminal domain containing 1 | |
Synonyms | CNTD | |
Cytomap | UCSC genome browser: 17q21.31 | |
Type of gene | protein-coding | |
RefGenes | NM_173478.2, | |
Description | cyclin N-terminal domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000176563 | ||
HPRD : 08271 | ||
Vega : OTTHUMG00000180652 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNTD1 | |
BioGPS: 124817 | ||
Pathway | NCI Pathway Interaction Database: CNTD1 | |
KEGG: CNTD1 | ||
REACTOME: CNTD1 | ||
Pathway Commons: CNTD1 | ||
Context | iHOP: CNTD1 | |
ligand binding site mutation search in PubMed: CNTD1 | ||
UCL Cancer Institute: CNTD1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CNTD1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CNTD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.317977402 | 0.397121209 | -1.715098611 | 2.72E-27 | 4.04E-26 |
KICH | -0.285124346 | 0.792343654 | -1.077468 | 4.98E-05 | 0.000138585 |
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TissGene-miRNA for CNTD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-185-5p | MIMAT0000455 | 0.015 | -0.33 | 56 |
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TissGeneMut for CNTD1 |
TissGeneSNV for CNTD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q280K | LIHC | 2 |
p.P201Q | LUAD | 1 |
p.C127X | THYM | 1 |
p.Q267K | LIHC | 1 |
p.Q107* | CESC | 1 |
p.E233K | BLCA | 1 |
p.S11F | BRCA | 1 |
p.W109X | SKCM | 1 |
p.A230V | STAD | 1 |
p.L153V | ACC | 1 |
p.A33S | PAAD | 1 |
p.R46W | UCEC | 1 |
p.L228* | MESO | 1 |
p.S44L | UCEC | 1 |
p.R137Q | COAD | 1 |
p.V169I | COAD | 1 |
p.Q16R | HNSC | 1 |
p.R123H | SKCM | 1 |
p.Q241H | SKCM | 1 |
p.R8Q | LGG | 1 |
p.W109* | SKCM | 1 |
p.Q75X | SKCM | 1 |
p.Q75* | SKCM | 1 |
p.S238N | PAAD | 1 |
p.A184S | LUAD | 1 |
p.S132N | SKCM | 1 |
p.K86I | LGG | 1 |
p.S106Y | UCS | 1 |
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TissGeneCNV for CNTD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNTD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA158625 | CNTD1-BECN1 | chr17:40963699 | chr17:40963699 |
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TissGeneNet for CNTD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNTD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNTD1 |
TissGeneDrug for CNTD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNTD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |