TissGeneSummary for LOXHD1 |
Gene summary |
Basic gene information | Gene symbol | LOXHD1 |
Gene name | lipoxygenase homology domains 1 | |
Synonyms | DFNB77|LH2D1 | |
Cytomap | UCSC genome browser: 18q21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001145472.2, NM_001145473.2,NM_001173129.1,NM_144612.6, | |
Description | lipoxygenase homology domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 613072 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167210 | ||
HPRD : 08316 | ||
Vega : OTTHUMG00000132644 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LOXHD1 | |
BioGPS: 125336 | ||
Pathway | NCI Pathway Interaction Database: LOXHD1 | |
KEGG: LOXHD1 | ||
REACTOME: LOXHD1 | ||
Pathway Commons: LOXHD1 | ||
Context | iHOP: LOXHD1 | |
ligand binding site mutation search in PubMed: LOXHD1 | ||
UCL Cancer Institute: LOXHD1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of LOXHD1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LOXHD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.002201071 | -1.196125071 | 1.193924 | 1.13E-07 | 7.87E-07 |
LUSC | 0.304147595 | 3.674657399 | -3.370509804 | 1.84E-26 | 4.87E-25 |
LUAD | 0.647551618 | 3.027146446 | -2.379594828 | 4.00E-25 | 1.66E-23 |
KIRP | -0.821175321 | 1.252002804 | -2.073178125 | 6.45E-14 | 1.33E-12 |
KICH | 3.454008929 | 1.749492929 | 1.704516 | 0.00391 | 0.007559333 |
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TissGene-miRNA for LOXHD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LOXHD1 |
TissGeneSNV for LOXHD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R1155G | PRAD | 2 |
p.N1866S | LIHC | 1 |
p.T883M | THYM | 1 |
p.A1641V | SARC | 1 |
p.H968Y | BRCA | 1 |
p.D1136G | UCEC | 1 |
p.K1505R | ESCA | 1 |
p.V764I | BRCA | 1 |
p.T883S | LIHC | 1 |
p.P506T | UCEC | 1 |
p.E953D | ESCA | 1 |
p.V573I | READ | 1 |
p.N165H | READ | 1 |
p.G260A | LIHC | 1 |
p.Q499R | UCEC | 1 |
p.V128I | READ | 1 |
p.L1400I | KIRC | 1 |
p.E341D | COAD | 1 |
p.Q92H | COAD | 1 |
p.V2211A | SARC | 1 |
p.P405S | COAD | 1 |
p.T1209I | KIRC | 1 |
p.A1406T | UCEC | 1 |
p.T66K | COAD | 1 |
p.R42W | READ | 1 |
p.L577R | DLBC | 1 |
p.E1169K | UCEC | 1 |
p.W49* | BRCA | 1 |
p.E1093* | UCEC | 1 |
p.P228L | MESO | 1 |
p.E1493* | LUAD | 1 |
p.R206C | COAD | 1 |
p.R1800W | UCEC | 1 |
p.G1725R | LIHC | 1 |
p.V363I | COAD | 1 |
p.E1493V | LUAD | 1 |
p.I199V | ACC | 1 |
p.D570N | SARC | 1 |
p.S421I | UCEC | 1 |
p.K1060R | SARC | 1 |
p.T2M | READ | 1 |
p.S2084R | SARC | 1 |
p.A1858D | LUAD | 1 |
p.L460I | COAD | 1 |
p.A45V | UCEC | 1 |
p.G632C | DLBC | 1 |
p.E1006K | COAD | 1 |
p.I829M | UCEC | 1 |
p.D860N | UCEC | 1 |
p.R271C | UCEC | 1 |
p.R1277H | CESC | 1 |
p.Y1352H | UCEC | 1 |
p.A186V | THYM | 1 |
p.L460I | ESCA | 1 |
p.D711Y | ESCA | 1 |
p.N317D | UCEC | 1 |
p.W1000* | OV | 1 |
p.G126X | COAD | 1 |
p.G1370E | SARC | 1 |
p.R637W | BRCA | 1 |
p.D1467N | UCEC | 1 |
p.R587Q | ACC | 1 |
p.R63Q | UCEC | 1 |
p.G1711D | KIRC | 1 |
p.H1506Y | BRCA | 1 |
p.Q984X | THYM | 1 |
p.R44G | SKCM | 1 |
p.S314Y | LIHC | 1 |
p.K904N | BRCA | 1 |
p.G967R | BRCA | 1 |
p.V1813I | ESCA | 1 |
p.I236M | SARC | 1 |
p.A1684T | UCEC | 1 |
p.E332K | BRCA | 1 |
p.R383X | COAD | 1 |
p.R434H | COAD | 1 |
p.L73I | THYM | 1 |
p.K939R | LIHC | 1 |
p.D1909A | KIRC | 1 |
p.E1957K | DLBC | 1 |
p.R751W | UCEC | 1 |
p.A337V | COAD | 1 |
p.S696Y | COAD | 1 |
p.Y1351C | UCEC | 1 |
p.S942Y | UCEC | 1 |
p.R1917H | OV | 1 |
p.G1676D | ESCA | 1 |
p.R2133C | UCEC | 1 |
p.R444H | READ | 1 |
p.N1552K | ACC | 1 |
p.K1220T | ESCA | 1 |
p.I1310V | ACC | 1 |
p.L648I | COAD | 1 |
p.R1089W | UCEC | 1 |
p.W1102C | LIHC | 1 |
p.G626C | DLBC | 1 |
p.E993K | CESC | 1 |
p.E268K | COAD | 1 |
p.D498N | READ | 1 |
p.Q984X | ESCA | 1 |
p.T1038I | UCEC | 1 |
p.R1084C | UCEC | 1 |
p.D669N | UCEC | 1 |
p.E512G | COAD | 1 |
p.R407C | OV | 1 |
p.Q588R | UCEC | 1 |
p.N2179D | UCEC | 1 |
p.A591V | UCEC | 1 |
p.G337D | COAD | 1 |
p.E474K | COAD | 1 |
p.R456C | COAD | 1 |
p.P497S | UCEC | 1 |
p.C1020* | UCEC | 1 |
p.R812W | UCEC | 1 |
p.D292N | UCEC | 1 |
p.R96Q | ESCA | 1 |
p.P251L | UCEC | 1 |
p.A1241T | BRCA | 1 |
p.E968A | ESCA | 1 |
p.K1227T | UCEC | 1 |
p.F1403L | UCEC | 1 |
p.G630S | COAD | 1 |
p.T760I | UCEC | 1 |
p.R2138W | UCEC | 1 |
p.A1941D | LIHC | 1 |
p.E215K | BRCA | 1 |
p.R547C | COAD | 1 |
p.Q793P | COAD | 1 |
p.R137H | ESCA | 1 |
p.R1090Q | DLBC | 1 |
p.G1201A | ESCA | 1 |
p.A483V | COAD | 1 |
p.R239C | COAD | 1 |
p.E1967K | ESCA | 1 |
p.T174M | COAD | 1 |
p.P228T | KIRC | 1 |
p.Q984* | THYM | 1 |
p.D1172Y | DLBC | 1 |
p.N441K | ACC | 1 |
p.E350K | COAD | 1 |
p.D676N | DLBC | 1 |
p.Q1187H | UCEC | 1 |
p.N357K | READ | 1 |
p.R263I | READ | 1 |
p.N480D | UCEC | 1 |
p.R814C | UCEC | 1 |
p.R1099W | UCEC | 1 |
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TissGeneCNV for LOXHD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LOXHD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BI008366 | LOXHD1-S100A6 | chr18:44201991 | chr1:153507129 | |
Chimerdb3.0 | ChiTaRs | NA | BQ327794 | LOXHD1-S100A6 | chr18:44201991 | chr1:153507133 | |
Chimerdb3.0 | ChiTaRs | NA | BI481187 | LOXHD1-OLFM4 | chr18:44069351 | chr13:53607269 |
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TissGeneNet for LOXHD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LOXHD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LOXHD1 |
TissGeneDrug for LOXHD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LOXHD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 3 | BeFree |
umls:C0016781 | Fuchs Endothelial Dystrophy | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C2746083 | DEAFNESS, AUTOSOMAL RECESSIVE 77 (disorder) | 0 | CLINVAR,CTD_human |