TissGeneSummary for ADH1C |
Gene summary |
Basic gene information | Gene symbol | ADH1C |
Gene name | alcohol dehydrogenase 1C (class I), gamma polypeptide | |
Synonyms | ADH3 | |
Cytomap | UCSC genome browser: 4q23 | |
Type of gene | protein-coding | |
RefGenes | NM_000669.4, | |
Description | ADH, gamma subunitalcohol dehydrogenase 1Calcohol dehydrogenase 3 (class I), gamma polypeptidealdehyde reductase | |
Modification date | 20141207 | |
dbXrefs | MIM : 103730 | |
HGNC : HGNC | ||
Ensembl : ENSG00000248144 | ||
HPRD : 00066 | ||
Vega : OTTHUMG00000161422 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADH1C | |
BioGPS: 126 | ||
Pathway | NCI Pathway Interaction Database: ADH1C | |
KEGG: ADH1C | ||
REACTOME: ADH1C | ||
Pathway Commons: ADH1C | ||
Context | iHOP: ADH1C | |
ligand binding site mutation search in PubMed: ADH1C | ||
UCL Cancer Institute: ADH1C | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ADH1C | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006069 | ethanol oxidation | 6391957 | GO:0006069 | ethanol oxidation | 6391957 |
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TissGeneExp for ADH1C |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -2.363298548 | 1.308657266 | -3.671955814 | 7.60E-09 | 9.55E-08 |
THCA | -4.259519518 | -1.362263586 | -2.897255932 | 5.69E-25 | 9.00E-23 |
LIHC | 6.250859126 | 9.961229126 | -3.71037 | 7.21E-10 | 8.05E-09 |
KIRP | -2.817466499 | 3.257692876 | -6.075159375 | 5.28E-24 | 5.92E-22 |
COAD | 2.192610664 | 7.598626049 | -5.406015385 | 4.11E-10 | 4.95E-09 |
KIRC | -3.137674485 | 3.407701904 | -6.545376389 | 1.07E-56 | 3.43E-54 |
BRCA | -1.80788947 | 2.788787723 | -4.596677193 | 4.72E-42 | 1.66E-40 |
BLCA | -0.8190114 | 2.119830705 | -2.938842105 | 0.00447 | 0.024425749 |
LUAD | -0.053438805 | 1.256006023 | -1.309444828 | 0.00348 | 0.006847053 |
KICH | 0.740323126 | 3.442463126 | -2.70214 | 0.000586 | 0.001320597 |
LUSC | -0.678053815 | 1.295605008 | -1.973658824 | 5.95E-05 | 0.000126053 |
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TissGene-miRNA for ADH1C |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADH1C |
TissGeneSNV for ADH1C |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E51D | LUAD | 1 |
p.P192L | LUAD | 1 |
p.E327K | UCEC | 1 |
p.S368C | LUAD | 1 |
p.K229N | UCEC | 1 |
p.V372I | STAD | 1 |
p.G317* | UCEC | 1 |
p.E28D | STAD | 1 |
p.K189N | UCEC | 1 |
p.G321E | HNSC | 1 |
p.F360C | UCEC | 1 |
p.A222D | STAD | 1 |
p.S365C | UCEC | 1 |
p.K19N | UCEC | 1 |
p.S183T | STAD | 1 |
p.I369V | OV | 1 |
p.K248N | UCEC | 1 |
p.E75K | HNSC | 1 |
p.T314M | BRCA | 1 |
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TissGeneCNV for ADH1C |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADH1C |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADH1C |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADH1C |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADH1C |
TissGeneDrug for ADH1C |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADH1C |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001973 | Alcoholic Intoxication, Chronic | 66 | BeFree,CTD_human,GAD |
umls:C0023891 | Liver Cirrhosis, Alcoholic | 12 | BeFree,GAD |
umls:C0007137 | Squamous cell carcinoma | 11 | BeFree,GAD,LHGDN |
umls:C1527249 | Colorectal Cancer | 11 | BeFree,GAD |
umls:C0006142 | Malignant neoplasm of breast | 10 | BeFree,GAD |
umls:C0278996 | Cancer of Head and Neck | 10 | BeFree,GAD |
umls:C0546837 | Malignant neoplasm of esophagus | 10 | BeFree,GAD |
umls:C0018671 | Head and Neck Neoplasms | 9 | GAD |
umls:C0023890 | Liver Cirrhosis | 9 | BeFree,GAD |
umls:C0014859 | Esophageal Neoplasms | 8 | BeFree,GAD |
umls:C0085762 | Alcohol abuse | 8 | BeFree,GAD |
umls:C0678222 | Breast Carcinoma | 8 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 7 | BeFree |
umls:C0023896 | Alcoholic Liver Diseases | 7 | BeFree,GAD |
umls:C0026640 | Mouth Neoplasms | 7 | CTD_human,GAD |
umls:C0149521 | Pancreatitis, Chronic | 7 | BeFree,GAD |
umls:C0376670 | Pancreatitis, Alcoholic | 7 | BeFree,GAD |
umls:C1623038 | Cirrhosis | 7 | BeFree,GAD |
umls:C0023895 | Liver diseases | 6 | BeFree |
umls:C0030305 | Pancreatitis | 6 | BeFree,GAD |
umls:C0010068 | Coronary heart disease | 5 | BeFree,GAD,LHGDN |
umls:C0023055 | Laryngeal neoplasm | 5 | GAD,LHGDN |
umls:C0153381 | Malignant neoplasm of mouth | 5 | BeFree,GAD |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 5 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 4 | BeFree,GAD |
umls:C0152018 | Esophageal carcinoma | 4 | BeFree |
umls:C0220641 | Lip and Oral Cavity Carcinoma | 4 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 4 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 4 | BeFree,GAD |
umls:C0687132 | heavy drinking | 4 | BeFree |
umls:C1956346 | Coronary Artery Disease | 4 | BeFree,GAD |
umls:C0007107 | Malignant neoplasm of larynx | 3 | BeFree,GAD |
umls:C0016382 | Flushing | 3 | BeFree,GAD |
umls:C0024623 | Malignant neoplasm of stomach | 3 | BeFree |
umls:C0027051 | Myocardial Infarction | 3 | BeFree,GAD |
umls:C0031347 | Pharyngeal Neoplasms | 3 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree,GAD |
umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree,LHGDN |
umls:C0001956 | alcohol use disorder | 2 | BeFree |
umls:C0001969 | Alcoholic Intoxication | 2 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree,GAD |
umls:C0009404 | Colorectal Neoplasms | 2 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree,GAD |
umls:C0013295 | Duodenal Ulcer | 2 | BeFree |
umls:C0021368 | Inflammation | 2 | GAD |
umls:C0038356 | Stomach Neoplasms | 2 | GAD |
umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
umls:C0042721 | Viral hepatitis | 2 | BeFree |
umls:C0151526 | Premature Birth | 2 | GAD |
umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
umls:C0345904 | Malignant neoplasm of liver | 2 | BeFree,GAD |
umls:C0595989 | Carcinoma of larynx | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C1302401 | Adenoma of large intestine | 2 | BeFree |
umls:C2349952 | Oropharyngeal Carcinoma | 2 | BeFree,GAD |
umls:C0000768 | Congenital Abnormality | 1 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree,GAD |
umls:C0001957 | Alcohol Withdrawal Delirium | 1 | GAD |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0007114 | Malignant neoplasm of skin | 1 | GAD |
umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
umls:C0008925 | Cleft Palate | 1 | GAD |
umls:C0009376 | Colonic Polyps | 1 | GAD |
umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
umls:C0011053 | Deafness | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree,GAD |
umls:C0013146 | Drug abuse | 1 | BeFree |
umls:C0013182 | Drug Allergy | 1 | GAD |
umls:C0015929 | Fetal Diseases | 1 | GAD |
umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
umls:C0020523 | Immediate hypersensitivity | 1 | GAD |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
umls:C0027497 | Nausea | 1 | BeFree |
umls:C0028043 | Nicotine Dependence | 1 | BeFree |
umls:C0029445 | Bone necrosis | 1 | GAD |
umls:C0030567 | Parkinson Disease | 1 | BeFree,GAD,LHGDN |
umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
umls:C0033054 | Prenatal Exposure Delayed Effects | 1 | GAD |
umls:C0037274 | Dermatologic disorders | 1 | GAD |
umls:C0038580 | Substance Dependence | 1 | BeFree |
umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
umls:C0153382 | Malignant neoplasm of oropharynx | 1 | BeFree |
umls:C0153398 | Hypopharyngeal Cancer | 1 | GAD |
umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
umls:C0206677 | Adenomatous Polyps | 1 | BeFree,GAD |
umls:C0220810 | Congenital defects | 1 | BeFree |
umls:C0231218 | Malaise | 1 | BeFree |
umls:C0234215 | Sensory Discomfort | 1 | BeFree |
umls:C0264408 | Childhood asthma | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0342345 | Hypoparathyroidism - autosomal dominant | 1 | BeFree |
umls:C0343641 | Human papilloma virus infection | 1 | BeFree |
umls:C0426576 | Gastrointestinal symptom | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0683357 | Excessive drinking | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0810031 | alcohol-related liver disease | 1 | BeFree |
umls:C0858970 | Carcinogenicity | 1 | BeFree |
umls:C0877008 | Enzyme inhibition disorder | 1 | BeFree |
umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
umls:C1384666 | hearing impairment | 1 | GAD |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
umls:C1510472 | Drug Dependence | 1 | BeFree,GAD |
umls:C1837217 | Cleft lip, isolated | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C3714514 | Infection | 1 | GAD |
umls:C3887873 | Hearing Loss | 1 | GAD |
umls:C1838867 | PARKINSON DISEASE, MITOCHONDRIAL (disorder) | 0 | CLINVAR |
umls:C3160718 | PARKINSON DISEASE, LATE-ONSET | 0 | CTD_human |