TissGeneSummary for WDR88 |
Gene summary |
Basic gene information | Gene symbol | WDR88 |
Gene name | WD repeat domain 88 | |
Synonyms | PQWD | |
Cytomap | UCSC genome browser: 19q13.11 | |
Type of gene | protein-coding | |
RefGenes | NM_173479.3, | |
Description | PQQ repeat and WD repeat domain containingPQQ repeat and WD repeat-containing proteinWD repeat-containing protein 88 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000166359 | ||
HPRD : 14033 | ||
Vega : OTTHUMG00000180342 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR88 | |
BioGPS: 126248 | ||
Pathway | NCI Pathway Interaction Database: WDR88 | |
KEGG: WDR88 | ||
REACTOME: WDR88 | ||
Pathway Commons: WDR88 | ||
Context | iHOP: WDR88 | |
ligand binding site mutation search in PubMed: WDR88 | ||
UCL Cancer Institute: WDR88 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADTGCT | |
Reference showing the relevant tissue of WDR88 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for WDR88 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.952116606 | -0.568172606 | -1.383944 | 1.92E-08 | 9.77E-08 |
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TissGene-miRNA for WDR88 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WDR88 |
TissGeneSNV for WDR88 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G100W | LUAD | 1 |
p.R65K | LUAD | 1 |
p.V149A | KIRP | 1 |
p.L90F | SKCM | 1 |
p.N374K | LIHC | 1 |
p.S292Y | LIHC | 1 |
p.S372C | THYM | 1 |
p.V438A | STAD | 1 |
p.A62T | STAD | 1 |
p.R308* | STAD | 1 |
p.S203L | LUAD | 1 |
p.A162V | STAD | 1 |
p.A39V | STAD | 1 |
p.W390L | THYM | 1 |
p.I219V | UCS | 1 |
p.S223F | SKCM | 1 |
p.S99R | LUAD | 1 |
p.S292F | SKCM | 1 |
p.P21L | SKCM | 1 |
p.C310R | COAD | 1 |
p.R355W | HNSC | 1 |
p.Q243H | BLCA | 1 |
p.E27V | LUSC | 1 |
p.F341L | GBM | 1 |
p.P79Q | LUAD | 1 |
p.R441Q | HNSC | 1 |
p.R252K | READ | 1 |
p.P60L | SKCM | 1 |
p.R138C | UCEC | 1 |
p.E394X | COAD | 1 |
p.H286Y | STAD | 1 |
p.W390C | LUSC | 1 |
p.V224I | COAD | 1 |
p.D173N | SKCM | 1 |
p.D88N | HNSC | 1 |
p.F95L | LUSC | 1 |
p.A216P | LUSC | 1 |
p.S249A | LUSC | 1 |
p.P69L | LIHC | 1 |
p.A216T | UCEC | 1 |
p.V438M | UCEC | 1 |
p.T429N | DLBC | 1 |
p.K383* | UCEC | 1 |
p.S48L | SKCM | 1 |
p.R40K | SKCM | 1 |
p.D139N | UCEC | 1 |
p.R308* | HNSC | 1 |
p.R417K | SKCM | 1 |
p.D239Y | DLBC | 1 |
p.V438M | COAD | 1 |
p.R308X | STAD | 1 |
p.K295R | TGCT | 1 |
p.R308* | UCEC | 1 |
p.A312S | PAAD | 1 |
p.I161V | SKCM | 1 |
p.V314L | LUAD | 1 |
p.D206N | COAD | 1 |
p.G353D | STAD | 1 |
p.R385M | STAD | 1 |
p.T221I | SKCM | 1 |
p.G285D | STAD | 1 |
p.R308* | SKCM | 1 |
p.P67S | PRAD | 1 |
p.I337M | COAD | 1 |
p.S334F | UCEC | 1 |
p.R138S | LUAD | 1 |
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TissGeneCNV for WDR88 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WDR88 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ339888 | WDR88-ZNF592 | chr19:33651465 | chr15:85326519 | |
Chimerdb3.0 | FusionScan | CESC | TCGA-C5-A907-01A | ZNF677-WDR88 | 5'UTR-CDS | chr19:53758086 | chr19:33666301 |
Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A9WL-01A | URI1-WDR88 | In-Frame | chr19:30433571 | chr19:33655102 |
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TissGeneNet for WDR88 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WDR88 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WDR88 |
TissGeneDrug for WDR88 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WDR88 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |