TissGeneSummary for CCDC105 |
Gene summary |
Basic gene information | Gene symbol | CCDC105 |
Gene name | coiled-coil domain containing 105 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19p13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_173482.2, | |
Description | coiled-coil domain-containing protein 105 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000160994 | ||
HPRD : 08280 | ||
Vega : OTTHUMG00000183352 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC105 | |
BioGPS: 126402 | ||
Pathway | NCI Pathway Interaction Database: CCDC105 | |
KEGG: CCDC105 | ||
REACTOME: CCDC105 | ||
Pathway Commons: CCDC105 | ||
Context | iHOP: CCDC105 | |
ligand binding site mutation search in PubMed: CCDC105 | ||
UCL Cancer Institute: CCDC105 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC105 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC105 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC105 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC105 |
TissGeneSNV for CCDC105 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W201* | SKCM | 4 |
p.P499T | READ | 2 |
p.R395K | SKCM | 2 |
p.P499T | PCPG | 2 |
p.Q243K | PRAD | 1 |
p.A438T | LGG | 1 |
p.R22C | COAD | 1 |
p.G80V | READ | 1 |
p.G63A | STAD | 1 |
p.M217I | SKCM | 1 |
p.G355R | LUSC | 1 |
p.R156L | DLBC | 1 |
p.P486L | UCEC | 1 |
p.G359E | SKCM | 1 |
p.R156L | PRAD | 1 |
p.Q402R | LUAD | 1 |
p.P282H | UCEC | 1 |
p.G355X | ESCA | 1 |
p.E202K | SKCM | 1 |
p.D216N | SKCM | 1 |
p.M357I | CESC | 1 |
p.R414H | STAD | 1 |
p.G355E | LUSC | 1 |
p.E391X | STAD | 1 |
p.L362I | UCEC | 1 |
p.Q157R | LIHC | 1 |
p.S208I | STAD | 1 |
p.R231* | LUSC | 1 |
p.R269* | PAAD | 1 |
p.P499T | COAD | 1 |
p.R261H | STAD | 1 |
p.S268F | SKCM | 1 |
p.A292T | SKCM | 1 |
p.S208I | UCEC | 1 |
p.H262Y | BRCA | 1 |
p.G376D | SKCM | 1 |
p.A137T | PAAD | 1 |
p.H127Q | SARC | 1 |
p.E313D | SKCM | 1 |
p.R363W | STAD | 1 |
p.A416T | UCEC | 1 |
p.R414H | LUSC | 1 |
p.A296V | GBM | 1 |
p.T353M | SARC | 1 |
p.R462H | OV | 1 |
p.L84* | LUAD | 1 |
p.S383L | COAD | 1 |
p.T45I | SKCM | 1 |
p.R302Q | GBM | 1 |
p.E218K | SKCM | 1 |
p.Q278* | SKCM | 1 |
p.P499T | BRCA | 1 |
p.E204K | SKCM | 1 |
p.M213I | HNSC | 1 |
p.Q417K | LUAD | 1 |
p.R468Q | LUSC | 1 |
p.I378M | CESC | 1 |
p.R399C | SKCM | 1 |
p.Q469E | LUAD | 1 |
p.P110L | STAD | 1 |
p.M209I | LUAD | 1 |
p.A259V | LUSC | 1 |
p.A300V | STAD | 1 |
p.Y401C | HNSC | 1 |
p.C424F | LGG | 1 |
p.R414H | UCEC | 1 |
p.R269X | PAAD | 1 |
p.E391* | STAD | 1 |
p.E435K | SKCM | 1 |
p.E370G | KIRC | 1 |
p.E240D | SARC | 1 |
p.G376S | UCEC | 1 |
p.F73Y | LIHC | 1 |
p.E240K | SKCM | 1 |
p.R399H | PRAD | 1 |
p.R399H | UCEC | 1 |
p.S263* | LUAD | 1 |
p.A390V | HNSC | 1 |
p.K316E | SKCM | 1 |
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TissGeneCNV for CCDC105 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC105 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-5479-01A | MZF1-CCDC105 | In-frame | Chr19:59080883 | Chr19:15131273 |
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TissGeneNet for CCDC105 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC105 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC105 |
TissGeneDrug for CCDC105 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC105 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |