TissGeneSummary for TDRD10 |
Gene summary |
Basic gene information | Gene symbol | TDRD10 |
Gene name | tudor domain containing 10 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001098475.1, NM_182499.3, | |
Description | tudor domain-containing protein 10 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000163239 | ||
HPRD : 13196 | ||
Vega : OTTHUMG00000037264 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TDRD10 | |
BioGPS: 126668 | ||
Pathway | NCI Pathway Interaction Database: TDRD10 | |
KEGG: TDRD10 | ||
REACTOME: TDRD10 | ||
Pathway Commons: TDRD10 | ||
Context | iHOP: TDRD10 | |
ligand binding site mutation search in PubMed: TDRD10 | ||
UCL Cancer Institute: TDRD10 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisUterus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUCEC,UCS | |
Reference showing the relevant tissue of TDRD10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TDRD10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -2.1531932 | -0.965902575 | -1.187290625 | 7.47E-06 | 9.13E-05 |
BRCA | -2.151333771 | 0.684253072 | -2.835586842 | 8.76E-62 | 5.02E-59 |
LUAD | -0.475609149 | 1.891299472 | -2.366908621 | 5.98E-11 | 3.67E-10 |
LUSC | -2.039645896 | 1.963330574 | -4.002976471 | 3.56E-33 | 2.97E-31 |
COAD | -2.819048008 | -1.144171085 | -1.674876923 | 1.42E-10 | 1.94E-09 |
ESCA | -2.376182973 | -1.123364791 | -1.252818182 | 0.00578 | 0.043281886 |
KIRP | -1.9130432 | -0.73082445 | -1.18221875 | 0.000845 | 0.002374048 |
BLCA | -2.29617149 | -0.375118858 | -1.921052632 | 9.47E-05 | 0.001047825 |
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TissGene-miRNA for TDRD10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TDRD10 |
TissGeneSNV for TDRD10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P205S | SKCM | 2 |
p.P122L | STAD | 1 |
p.V192I | LGG | 1 |
p.G68C | ESCA | 1 |
p.P164L | ESCA | 1 |
p.P122L | LGG | 1 |
p.E154D | COAD | 1 |
p.F29L | LUAD | 1 |
p.F57L | HNSC | 1 |
p.K346M | KIRP | 1 |
p.R98Q | SKCM | 1 |
p.R181* | BRCA | 1 |
p.M167T | PAAD | 1 |
p.G194R | SKCM | 1 |
p.T201A | STAD | 1 |
p.V102M | BRCA | 1 |
p.A137T | READ | 1 |
p.Q66X | ESCA | 1 |
p.R193L | STAD | 1 |
p.P122S | SKCM | 1 |
p.L309Q | LIHC | 1 |
p.T201M | HNSC | 1 |
p.C179Y | THYM | 1 |
p.D302N | STAD | 1 |
p.E49K | SKCM | 1 |
p.E126D | UCEC | 1 |
p.P8S | UCEC | 1 |
p.Q66* | ESCA | 1 |
p.G248E | COAD | 1 |
p.E126D | LUSC | 1 |
p.R193L | LUAD | 1 |
p.E195K | SKCM | 1 |
p.G285R | SKCM | 1 |
p.A128T | STAD | 1 |
p.A288V | STAD | 1 |
p.G92A | LUAD | 1 |
p.G169V | LUAD | 1 |
p.A143T | HNSC | 1 |
p.R107S | COAD | 1 |
p.A121V | UCEC | 1 |
p.P42S | SKCM | 1 |
p.E166G | LIHC | 1 |
p.S170F | SKCM | 1 |
p.I45T | HNSC | 1 |
p.N58S | LUSC | 1 |
p.R296H | STAD | 1 |
p.K47* | LUAD | 1 |
p.D283Y | UCEC | 1 |
p.V192I | GBM | 1 |
p.E235K | CESC | 1 |
p.R296C | UCEC | 1 |
p.D271N | SKCM | 1 |
p.R193H | LAML | 1 |
p.R98Q | KIRC | 1 |
p.G78S | STAD | 1 |
p.A196P | SKCM | 1 |
p.D56N | SKCM | 1 |
p.G78V | CHOL | 1 |
p.P59H | PRAD | 1 |
p.H190Q | OV | 1 |
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TissGeneCNV for TDRD10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TDRD10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A1FW-01A | C20orf194-TDRD10 | Out-of-frame | Chr20:3354695 | Chr1:154514500 |
TCGAfusionPortal | PRADA | SKCM | TCGA-EB-A6QY-01A | CTSS-TDRD10 | In-frame | Chr1:150720253 | Chr1:154519885 |
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TissGeneNet for TDRD10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TDRD10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TDRD10 |
TissGeneDrug for TDRD10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TDRD10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |