TissGeneSummary for WDR63 |
Gene summary |
Basic gene information | Gene symbol | WDR63 |
Gene name | WD repeat domain 63 | |
Synonyms | DIC3|NYD-SP29 | |
Cytomap | UCSC genome browser: 1p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001288563.1, NM_145172.4, | |
Description | WD repeat-containing protein 63testis development protein NYD-SP29 (NYD-SP29) | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162643 | ||
HPRD : 11409 | ||
Vega : OTTHUMG00000009953 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR63 | |
BioGPS: 126820 | ||
Pathway | NCI Pathway Interaction Database: WDR63 | |
KEGG: WDR63 | ||
REACTOME: WDR63 | ||
Pathway Commons: WDR63 | ||
Context | iHOP: WDR63 | |
ligand binding site mutation search in PubMed: WDR63 | ||
UCL Cancer Institute: WDR63 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of WDR63 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for WDR63 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.12509502 | 3.382981294 | -3.257886275 | 1.09E-15 | 7.46E-15 |
KIRC | 0.370921817 | 2.240905151 | -1.869983333 | 4.08E-18 | 2.69E-17 |
LUAD | 1.139084844 | 3.249977948 | -2.110893103 | 4.65E-08 | 1.91E-07 |
HNSC | 0.278659543 | 1.441894427 | -1.163234884 | 0.000633 | 0.0022788 |
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TissGene-miRNA for WDR63 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WDR63 |
TissGeneSNV for WDR63 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R504Q | UCEC | 2 |
p.P547S | SKCM | 2 |
p.R828C | UCEC | 2 |
p.D596N | SKCM | 1 |
p.G738R | ACC | 1 |
p.E642D | SKCM | 1 |
p.E642K | UCEC | 1 |
p.S162Y | COAD | 1 |
p.Q510* | SKCM | 1 |
p.K832Q | SKCM | 1 |
p.R187X | COAD | 1 |
p.D399N | OV | 1 |
p.E819K | UCEC | 1 |
p.N875D | UCEC | 1 |
p.R828C | READ | 1 |
p.E836X | READ | 1 |
p.L280F | SARC | 1 |
p.G729R | UCEC | 1 |
p.I301S | LGG | 1 |
p.R828H | GBM | 1 |
p.P451_splice | GBM | 1 |
p.N252S | LUAD | 1 |
p.R79C | THYM | 1 |
p.F262L | READ | 1 |
p.R526I | ESCA | 1 |
p.L78M | LGG | 1 |
p.H321Y | SKCM | 1 |
p.R55X | COAD | 1 |
p.T255K | SKCM | 1 |
p.V90G | LUAD | 1 |
p.V342I | STAD | 1 |
p.P146S | HNSC | 1 |
p.R55* | STAD | 1 |
p.E462* | UCEC | 1 |
p.W523* | TGCT | 1 |
p.I418M | HNSC | 1 |
p.K224E | STAD | 1 |
p.E475G | STAD | 1 |
p.R55X | STAD | 1 |
p.E126* | UCEC | 1 |
p.R359* | STAD | 1 |
p.H809N | LUAD | 1 |
p.P28L | SKCM | 1 |
p.R828S | PAAD | 1 |
p.P387L | HNSC | 1 |
p.R365T | CESC | 1 |
p.E642K | COAD | 1 |
p.E642K | READ | 1 |
p.R81I | LUAD | 1 |
p.H486R | SKCM | 1 |
p.S286C | HNSC | 1 |
p.T313S | HNSC | 1 |
p.E122K | BLCA | 1 |
p.P551A | LUSC | 1 |
p.W743* | LUAD | 1 |
p.F192Y | GBM | 1 |
p.M660T | BLCA | 1 |
p.S333I | COAD | 1 |
p.A215D | UCEC | 1 |
p.R798H | COAD | 1 |
p.E493K | HNSC | 1 |
p.S681P | LIHC | 1 |
p.T313I | SKCM | 1 |
p.I688T | LGG | 1 |
p.D319N | CESC | 1 |
p.N220T | STAD | 1 |
p.D490N | LUSC | 1 |
p.E63* | LUAD | 1 |
p.T255M | CESC | 1 |
p.Q49K | STAD | 1 |
p.Q326L | GBM | 1 |
p.D109Y | UCEC | 1 |
p.H367N | BRCA | 1 |
p.F634L | STAD | 1 |
p.S355L | GBM | 1 |
p.R189Q | UCEC | 1 |
p.R187Q | LGG | 1 |
p.R526I | UCEC | 1 |
p.F554L | SKCM | 1 |
p.E143* | UCEC | 1 |
p.P250S | SKCM | 1 |
p.C54Y | KIRC | 1 |
p.D77N | PCPG | 1 |
p.E32D | OV | 1 |
p.G734D | STAD | 1 |
p.S755Y | LUAD | 1 |
p.A447V | STAD | 1 |
p.I763M | BLCA | 1 |
p.W344C | LGG | 1 |
p.E542V | LUAD | 1 |
p.A82D | HNSC | 1 |
p.R359X | STAD | 1 |
p.Q848E | BLCA | 1 |
p.T255M | STAD | 1 |
p.W523X | TGCT | 1 |
p.N252S | ESCA | 1 |
p.L129I | SKCM | 1 |
p.T513I | COAD | 1 |
p.R828C | SKCM | 1 |
p.Q510X | SKCM | 1 |
p.R55L | LGG | 1 |
p.I39M | UCEC | 1 |
p.R735L | LUSC | 1 |
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TissGeneCNV for WDR63 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WDR63 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for WDR63 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WDR63 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WDR63 |
TissGeneDrug for WDR63 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WDR63 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |