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TissGeneSummary for KLHDC9 |
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Basic gene information | Gene symbol | KLHDC9 |
Gene name | kelch domain containing 9 | |
Synonyms | KARCA1 | |
Cytomap | UCSC genome browser: 1q23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001007256.1, NM_001007255.2,NM_152366.4,NR_033385.1,NR_033386.1, | |
Description | kelch domain-containing protein 9kelch/ankyrin repeat-containing cyclin A1-interacting protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162755 | ||
HPRD : 13751 | ||
Vega : OTTHUMG00000031479 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLHDC9 | |
BioGPS: 126823 | ||
Pathway | NCI Pathway Interaction Database: KLHDC9 | |
KEGG: KLHDC9 | ||
REACTOME: KLHDC9 | ||
Pathway Commons: KLHDC9 | ||
Context | iHOP: KLHDC9 | |
ligand binding site mutation search in PubMed: KLHDC9 | ||
UCL Cancer Institute: KLHDC9 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KLHDC9 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for KLHDC9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.478354406 | 1.559155794 | -1.080801389 | 1.18E-18 | 8.19E-18 |
KICH | 0.73170135 | 2.28632135 | -1.55462 | 4.23E-12 | 4.36E-11 |
LUSC | -1.002332768 | 0.052794683 | -1.055127451 | 0.000161 | 0.000326054 |
HNSC | -2.512508417 | -1.117013069 | -1.395495349 | 6.54E-05 | 0.000309789 |
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TissGene-miRNA for KLHDC9 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLHDC9 |
TissGeneSNV for KLHDC9 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S171R | PCPG | 2 |
p.S171R | BRCA | 2 |
p.D347N | STAD | 1 |
p.L232F | SKCM | 1 |
p.G237E | SKCM | 1 |
p.G237R | HNSC | 1 |
p.E53K | SKCM | 1 |
p.M239T | STAD | 1 |
p.A185T | SKCM | 1 |
p.G221R | KIRP | 1 |
p.G210E | CESC | 1 |
p.R103C | GBM | 1 |
p.S171R | UVM | 1 |
p.R318H | COAD | 1 |
p.D335N | PRAD | 1 |
p.R318C | UCEC | 1 |
p.K254E | COAD | 1 |
p.W15R | LIHC | 1 |
p.D57N | LUSC | 1 |
p.P198A | LUAD | 1 |
p.A192E | LUAD | 1 |
p.G236R | SKCM | 1 |
p.R9L | LIHC | 1 |
p.R318C | LUAD | 1 |
p.F231Y | PRAD | 1 |
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TissGeneCNV for KLHDC9 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLHDC9 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK123144 | ZNF333-KLHDC9 | chr19:14820628 | chr1:161069512 | |
Chimerdb3.0 | FusionScan | UCS | TCGA-N8-A4PP-01A | ENSA-KLHDC9 | Out-of-Frame | chr1:150598117 | chr1:161069850 |
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TissGeneNet for KLHDC9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLHDC9 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLHDC9 |
TissGeneDrug for KLHDC9 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLHDC9 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |