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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ADH4
check button Gene summary
Basic gene informationGene symbolADH4
Gene namealcohol dehydrogenase 4 (class II), pi polypeptide
SynonymsADH-2|HEL-S-4
CytomapUCSC genome browser: 4q22
Type of geneprotein-coding
RefGenesNM_000670.3,
Descriptionalcohol dehydrogenase 4alcohol dehydrogenase class II pi chainaldehyde reductaseepididymis secretory protein Li 4
Modification date20141207
dbXrefs MIM : 103740
HGNC : HGNC
Ensembl : ENSG00000198099
HPRD : 00068
Vega : OTTHUMG00000161227
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADH4
BioGPS: 127
PathwayNCI Pathway Interaction Database: ADH4
KEGG: ADH4
REACTOME: ADH4
Pathway Commons: ADH4
ContextiHOP: ADH4
ligand binding site mutation search in PubMed: ADH4
UCL Cancer Institute: ADH4
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of ADH4Toxicogenomics directory of chemically exposed human hepatocytes. Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG. Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16. (pmid:25399406)
go to article
Description by TissGene annotationsTissgsKTS
CNV gained TissGeneKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001523retinoid metabolic process15369820
GO:0006066alcohol metabolic process3466164
GO:0006069ethanol oxidation16787387
GO:0006081cellular aldehyde metabolic process3466164
GO:0042572retinol metabolic process16787387
GO:0001523retinoid metabolic process15369820
GO:0006066alcohol metabolic process3466164
GO:0006069ethanol oxidation16787387
GO:0006081cellular aldehyde metabolic process3466164
GO:0042572retinol metabolic process16787387


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TissGeneExp for ADH4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-0.677335561.533790829-2.2111263895.11E-204.05E-19
HNSC-0.7460420842.378241637-3.1242837216.47E-143.31E-12
BRCA-0.4749722562.755733008-3.2307052631.22E-372.89E-36
KIRP-0.5070859071.788723468-2.2958093752.34E-092.05E-08
LIHC10.2726412214.91812722-4.6454869.32E-121.50E-10


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TissGene-miRNA for ADH4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ADH4
TissGeneSNV for ADH4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G390ESKCM2
p.G159ESKCM2
p.G140ESKCM2
p.R318CCOAD1
p.V46IPCPG1
p.F182VLIHC1
p.V67IUCEC1
p.E331KBLCA1
p.V75MHNSC1
p.L397IUCS1
p.T137NLUSC1
p.A49VSARC1
p.I228TUCEC1
p.S199LSKCM1
p.G371ESKCM1
p.P255QLUAD1
p.F324LREAD1
p.G2VSTAD1
p.G277ESKCM1
p.R193KSKCM1
p.P80QLUSC1
p.K234TSTAD1
p.V228ESKCM1
p.M368VLIHC1
p.A62DLUAD1
p.V94MHNSC1
p.V53AHNSC1
p.A51ELUAD1
p.P32SSKCM1
p.E89GPRAD1
p.D368VTHCA1
p.S150RLUSC1
p.T133IPAAD1
p.P51SSKCM1
p.D385HCESC1
p.S218LSKCM1
p.K364ISKCM1
p.E277KSKCM1
p.V72AHNSC1
p.T152IPAAD1
p.S107TLIHC1
p.T219NTGCT1
p.P274QLUAD1
p.A43DLUAD1
p.A15TUCEC1
p.A90TSKCM1
p.R174KSKCM1
p.G240ESKCM1
p.G296ESKCM1
p.K345ISKCM1
p.D349VTHCA1
p.A70DLUAD1
p.E44KSKCM1


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TissGeneCNV for ADH4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ADH4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for ADH4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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COAD (tumor)COAD (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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HNSC (tumor)HNSC (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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KICH (tumor)KICH (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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KIRC (tumor)KIRC (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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KIRP (tumor)KIRP (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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LIHC (tumor)LIHC (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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LUAD (tumor)LUAD (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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LUSC (tumor)LUSC (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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PRAD (tumor)PRAD (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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STAD (tumor)STAD (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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THCA (tumor)THCA (normal)
ADH4, YWHAE, RPL35 (tumor)ADH4, YWHAE, RPL35 (normal)
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TissGeneProg for ADH4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ADH4
TissGeneDrug for ADH4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ADH4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0001973Alcoholic Intoxication, Chronic15BeFree,GAD
umls:C0009088Cluster Headache3BeFree
umls:C0038580Substance Dependence3BeFree
umls:C0085762Alcohol abuse3BeFree,GAD
umls:C0016382Flushing2BeFree,GAD
umls:C0546837Malignant neoplasm of esophagus2BeFree,GWASCAT
umls:C1510472Drug Dependence2BeFree,GAD
umls:C2239176Liver carcinoma2BeFree
umls:C0001956alcohol use disorder1BeFree
umls:C0011053Deafness1GAD
umls:C0014859Esophageal Neoplasms1BeFree
umls:C0018671Head and Neck Neoplasms1GAD
umls:C0018772Hearing Loss, Partial1GAD
umls:C0023893Liver Cirrhosis, Experimental1CTD_human
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0030305Pancreatitis1BeFree
umls:C0030567Parkinson Disease1GAD
umls:C0087169Withdrawal Symptoms1BeFree
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0156312Atrophy of testis1BeFree
umls:C0233849Personality Traits1GAD
umls:C0376670Pancreatitis, Alcoholic1BeFree
umls:C0600427Cocaine Dependence1GAD
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0877008Enzyme inhibition disorder1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1384666hearing impairment1GAD
umls:C3887873Hearing Loss1GAD