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| TissGeneSummary for OSCP1 |
 Gene summary |
| Basic gene information | Gene symbol | OSCP1 |
| Gene name | organic solute carrier partner 1 | |
| Synonyms | C1orf102|NOR1 | |
| Cytomap | UCSC genome browser: 1p34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_145047.4, NM_206837.2, | |
| Description | hOSCP1organic solute carrier protein 1organic solute transport protein 1oxidored nitro domain containing proteinoxidored-nitro domain-containing protein 1protein OSCP1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608854 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116885 | ||
| HPRD : 16393 | ||
| Vega : OTTHUMG00000008139 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OSCP1 | |
| BioGPS: 127700 | ||
| Pathway | NCI Pathway Interaction Database: OSCP1 | |
| KEGG: OSCP1 | ||
| REACTOME: OSCP1 | ||
| Pathway Commons: OSCP1 | ||
| Context | iHOP: OSCP1 | |
| ligand binding site mutation search in PubMed: OSCP1 | ||
| UCL Cancer Institute: OSCP1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of OSCP1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OSCP1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.829132729 | 0.763087271 | -1.59222 | 1.82E-15 | 4.09E-14 |
| LUSC | -1.26718316 | 0.334603114 | -1.601786275 | 2.19E-16 | 1.62E-15 |
| ESCA | -2.151095638 | -1.135186547 | -1.015909091 | 0.00477 | 0.03832 |
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| TissGene-miRNA for OSCP1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OSCP1 |
| TissGeneSNV for OSCP1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T141A | THCA | 2 |
| p.Q177R | SKCM | 1 |
| p.Y209H | COAD | 1 |
| p.E39K | HNSC | 1 |
| p.D168N | SKCM | 1 |
| p.H270Q | BRCA | 1 |
| p.Q167R | SKCM | 1 |
| p.E370K | SKCM | 1 |
| p.M385V | BLCA | 1 |
| p.L21I | LIHC | 1 |
| p.I219T | COAD | 1 |
| p.G14S | LUAD | 1 |
| p.E329Q | BLCA | 1 |
| p.S245Y | UCEC | 1 |
| p.Y249N | TGCT | 1 |
| p.M180I | UCEC | 1 |
| p.N346K | LUAD | 1 |
| p.E367Q | HNSC | 1 |
| p.R197C | SKCM | 1 |
| p.K34T | STAD | 1 |
| p.T131A | STAD | 1 |
| p.G194W | COAD | 1 |
| p.G234D | SKCM | 1 |
| p.Q273_splice | UCEC | 1 |
| p.N279I | LUSC | 1 |
| p.Q283H | UCEC | 1 |
| p.Y239N | TGCT | 1 |
| p.Q84L | LIHC | 1 |
| p.R159W | COAD | 1 |
| p.S129F | STAD | 1 |
| p.D178N | SKCM | 1 |
| p.Q94L | LIHC | 1 |
| p.G244D | SKCM | 1 |
| p.H76Y | CESC | 1 |
| p.E348Q | CESC | 1 |
| p.G193* | BRCA | 1 |
| p.G194E | COAD | 1 |
| p.V228I | SKCM | 1 |
| p.D33H | BRCA | 1 |
| p.I362M | OV | 1 |
| p.Q69E | BLCA | 1 |
| p.R36H | THYM | 1 |
| p.V238I | SKCM | 1 |
| p.S139F | STAD | 1 |
| p.E367Q | BRCA | 1 |
| p.T131A | COAD | 1 |
| p.F188L | LIHC | 1 |
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| TissGeneCNV for OSCP1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OSCP1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DB080871 | OSCP1-BMS1 | chr1:36884830 | chr10:43287073 |
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| TissGeneNet for OSCP1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for OSCP1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OSCP1 |
| TissGeneDrug for OSCP1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for OSCP1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2931822 | Nasopharyngeal carcinoma | 8 | BeFree |
| umls:C1275278 | Extraskeletal Myxoid Chondrosarcoma | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0008479 | Chondrosarcoma | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0020071 | Hereditary Sensory Autonomic Neuropathy, Type 1 | 1 | BeFree |
| umls:C0020437 | Hypercalcemia | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | BeFree |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | BeFree |
| umls:C0021053 | Immune System Diseases | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0030517 | Parathyroid Diseases | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0079541 | Holoprosencephaly | 1 | BeFree |
| umls:C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | BeFree |
| umls:C0085631 | Agitation | 1 | BeFree |
| umls:C0085702 | Monocytosis | 1 | BeFree |
| umls:C0153392 | Malignant neoplasm of nasopharynx | 1 | BeFree |
| umls:C0238301 | Cancer of Nasopharynx | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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